Curator Dashboard

Commercial organization which provides molecular modelling and cheminformatics software to the pharmaceutical industry.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Commercial ogranization which provides molecular and drug discovery software and services to researchers. American software company that develops chemical simulation software for use in pharmaceutical, biotechnology, and materials science research. Provides products ranging from general molecular modeling programs to a full suite of chemical simulation and drug design software, including ligand- and structure-based methods.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Molecular graphics environment which provides biologists and chemists with representations of proteins, DNA, RNA, and multiple sequence alignments. Users can build, annotate, and edit interactive views and slides of molecules. Users can also superimpose protein structures, search PDB, measure distanaces and angles, and view and make high resolution images of alignments.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core facility that provides access to genome-wide collections of cDNAs and siRNAs that can be used to interrogate cellular models of signal transduction pathways and phenotypes. Services include cell lines, hit-picking clones and various screening sets, and access to equipment.Provides instruments:Analyst Molecular Devices,Embla Molecular Devices, Envision Perkin Elmer, Platemate Matrix, Tecan M200, Wellmate Matrix.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Non-profit dedicated to conducting collaborative research to find cures for human disease, improve quality of life, and educate and train the next-generation of scientists. It is the overarching organization of more than a dozen core facilities that provide various resources in biomedical research.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core facility that supports assay development, high throughput (HTS), ultra-high throughput (uHTS), and high-content screening (HCS) activities performed at the Conrad Prebys Center for Chemical Genomics by providing databases and tools for compound registration and inventory, HTS plate formatting and tracking, HTS and HCS bioassay data processing as well as related data and information handling. Data mining and reporting are also facilitated with a user-friendly database interface. The Cheminformatics core also supports the design and obtaining of appropriate compound collections, as well as SAR follow-up of hits, hit-to-lead optimization and in silico screening through docking and other molecular modeling approaches.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Producer of antibodies for investigators to use as diagnostic tools and therapeutic reagents in their research studies. The center works in conjunction with the Department of Animal Resources, and is able to assist in all stages of both polyclonal and monoclonal antibody development.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Facility that aims to investigate role of metabolism in cancer on cellular and organismal level, combining in vitro and in vivo analysis. Comprehensive metabolic facility, including stable isotope tracing and flux analysis. Provides analysis of metabolism using specialist instruments and methodologies, together with advice on planning experiments and analyzing data. All instruments and approaches are available on fee-for-service basis to Cancer Center scientists, but alsoto outside users. Samples for most services can be shipped, but Seahorse analyzer users need to be local so they can bring live cells for analysis.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core facility that provides general synthetic and medicinal chemistry resources and expertise to the biomedical research community. Services include chemistry consulting for projects, grant applications, synthetic chemistry, medicinal chemistry, and analytical chemistry, as well as access to equipment for synthesis, purification, and analysis.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core facility that provides diverse screening instrumentation, compound libraries and expertise on high throughput screens and automation in support of collaborative, and user- or facility-driven screening projects. The facility collaborates with a number of partners to develop molecular therapies. Services available include consultation for high throughput screening approaches, conversion of assays to automation compatible formats and data analysis.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core facility that aims to develop cell based disease models for screening and testing small molecules and drugs, and specializes in culture, scaling, and directed differentiation of human embryonic and induced pluripotent stem cells. It provides resources and expertise to researchers at the Institute and to their external partners to facilitate development of stem cell based assays and patient-specific disease models in screenable formats.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core facility that provides access to the HTS plate and liquid handling infrastructure of the screening center, as well as the screening center�s cell culture facility. Other services include assay development, screening, and data analysis/mining expertise and services for high content screens. Consultation from the team is available for high content image-based screens including sample preparation, image acquisition, image analysis, image data management, and algorithm development.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on 11132025. Facility that provides database development and management and bioinformatic network building services by utilizing on-site hardware and software. Three members of the facility are available to assist researchers with advanced bioinformatics and biostatistics analysis to help put data into biological context across various disease areas to create testable hypotheses and understand biology of the process. The bulk of support includes connecting functional genomic data with pathways and networks, connecting gene/protein expression and disease state and consultations on statistical aspects of the research with the team statistician.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core facility that performs design, development, validation and pilot screening of biological high-throughput assays. It provides services such as designing and developing de-novo assays, converting low-throughput lab protocols (e.g. cuvette- or gel-based) into plate-based HTS assays, and access to major robotic equipment and resources. The facility also provides direct assistance with preparing screening-related grants, guidance through assay development stages, help in designing testing funnels, and generation of preliminary data.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core facility that provides sequencing services, access to equipment and consultation on experimental design and data analysis. Available instruments include the Life Technologies Ion Torrent PGM and Ion Proton sequencers. Core also provides amplification-free analysis of RNA expression using the NanoString nCounter, and additionally provides sequencing and analysis services to investigators outside of SBP. Included in the cost of sequencing is basic bioinformatic analysis (SNP/InDel calling, transcript abundance). Lastly, the core also provides advice on experimental design, and guidance on the capabilities of next-generation sequencing.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Facility that provides mass spectrometry-based proteomics services with methods tailored to the needs of scientific investigators for routine mass spectrometric analysis of peptides and proteins, identification of novel proteins, characterization of post-translational modifications, and quantitative proteomics analysis of simple to complex biological samples. The facility identifies, validates and develops new methods designed for the characterization and identification of biologically important proteins. It also supports users with software applications and development, data analysis and experimental design of proteomics studies.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Facility that provides cost-effective production of high-quality, high-titer lentiviral, retroviral and adenoviral vectors. Services include production of ready-to-transduce lentiviral and adenoviral particles, custom lentiviral, retroviral, and adenoviral production and titrations. Other activities of the facility include packaging, concentrating, and titration of user-supplied lentiviral constructs. Specialized services include custom lentiviral vector construction for constitutive or inducible cDNA/shRNA expression as well as promoter/enhancer reporter, viral packaging, and titration (ready-to-transduce control particles provided).

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Facility that provides full-service microarray-based global analysis of gene expression in RNA samples from humans or mice using an Illumina platform. Services include RNA sample quality and quantity analysis, microarray analysis, and Q-PCR service and analysis, as well as special services such as RNA purification and Copy Number Variation analysis.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Facility that provides a variety of analytical services focused on biophysical characterization of structural and functional properties of proteins in solution, under native, non-denaturing conditions. Examples of services include quality control of protein samples (folding, stability, aggregation); measuring molecular weight of proteins, protein complexes, oligomers and assemblies; charcaterizing protein conformation and shape in solution; determining oligomeric state of protein (including stoichiometry and Kd for self-association) and measuring protein binding to proteins, peptides, small molecules, compounds, metals, nucleotides and other ligands (including determination of equilibrium (Kd) and kinetic rate (kon, koff) constants, stoichiometry, binding enthalpy and entropy).

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Facility that acts as a centralized shared resource for NMR studies on proteins, peptides, small molecules, and carbohydrates in solution or in solid state. It provides instrumentation and expertise for NMR data collection. It also provides consultation with investigators on the feasibility of NMR for structural studies of protein candidates, as well as the optimal method to obtain solution structures and binding information by multi-dimensional NMR techniques. It can also train users in basic spectrometer operations, trouble-shoot for instrumental and operational problems, and set up NMR experiments for users as requested.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen