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Core facility which investigates the connections between chronic kidney disease, cardiovascular disease, and hypertension. It focuses specifically on investigating the pathophysiology, epidemiology, and therapeutic response in on-going studies or existing datasets of one of the three diseases with the aim of relating data from individual diseases to each other.
Imaging center which provides renal and urological researchers access to intravital optical microscopy and 3-dimensional quantitative digital image analysis.
Research program whose aim is to make state-of-the art technologies and resources accessible to a broad spectrum of investigators pursuing studies in kidney research areas.
Core facility that provides resources for investigators researching the genetic mechanisms of chronic kidney disease, cardiovascular disease, and hypertension. Its services include pre-study consultation, standardized services for DNA isolation and storage, and assisstance in carrying out molecular genetic studies.
Research center which investigates the mechanisms underlying the impact kidney disease has on cardiovascular morbidity and mortality using genetic and basic science approaches.
Core facility that provides access to a range of experimental models of kidney, heart and vascular diseases. It also provides comprehensive phenotyping services for kidney functions, blood pressure and other cardiovascular functions.
Core that provides measurement of serum and or urine Creatinine by Capillary Electrophoresis, measurement of serum and urine citrate by capillary electrophoresis, Microanalysis of serum and urine electrolytes by: Flame photometry, Atomic absorption or Ion-Selective Electrode, and Klotho IP-IB Assay.
Core that provides both morphological analysis of mucosal tissues and instructs investigators in the techniques used to prepare tissue sections and analyze the morphology and cellular components of the mucosa and primary human gut (intestinal and rectal) cells, gastric mononuclear cells and genital (cervical and vaginal) cells and instruction on how to construct mucosal tissue explants in a transwell chamber system.
Core facility that provides instrumentation and technical expertise for the preparation, acquisition and analysis of images of cells and tissues at the light microscopic level. Its services include confocal and super-resolution microscopy, epifluorescent microscopy with quantitative and ratio imaging, timelapse microscopy with image processing and analysis, multiphoton microscopy, and cryosectioning.
Core facility which generates and provides gnotobiotic and genetically engineered mice to research projects. It also provides specialized breeding, marker-assisted genotyping, and histopathologic evaluation services for studies using these mice.
Core composed of the Viral Unit, which provides labeled andn unlabeled viral components, and Bacterial Unit, which provides bacteria and bacterial proteins for research. The retroviral unit focues on the viral components of the retrovirus HIV-1.
Research center which investigates the interaction between microbes and mucosal tissues in humans. It provides three core facilities for research: the Genetically-Defined Microbe Core, the Molecular Pathology and Human Cell/Tissue Core, and the Gnotobiotic and Genetically-Engineered Mouse Core.
THIS RESOURCE IS NO LONGER IN SERVICE. Documented on June 15,2026. Core facility that provides advice and technical services to DDRCC investigators that include production of transgenic and chimeric mice, derivation of speed congenics and assisted reproduction services for maintaining pedigrees via the Mouse Genetics Core, as well as gnotobiotic mouse provision, colonization and rederivation.
Core facility which aims to develop an infrastructure for patient-oriented research by streamlining regulatory and compliance processes, obtaining and storing high-quality samples linked to clinical information, offering consultation in the design and implementation of clinical trials, and supplying statistical expertise for interpreting clinical and translational data.
Core facility that provides technical expertise, equipment and personnel to Liver Center Investigators who wish to work with animal models of liver disease, isolated liver cells, or gene expression in liver tissue. The Cell Isolation sub-core isolates hepatocytes and non-parenchymal liver cells primarily from rat and mouse, while the Molecular Biology sub-core provides equipment and expertise to Liver Center members in a centralized facility.
Core facility which acts as the administrative structure of the Liver Research Center. The activities it oversees include all scientific and administrative supervisory functions of the Center and its administrative leadership, including the organization and supervision of Core facilities, the planning and scheduling of the enrichment program and the review and oversight of individual pilot feasibility projects.
Core facility that collects and provides specimens and longitudinal clinical data from patients with digestive diseases. Specimens collected and processed by the core currently include blood, surgical resections, endoscopic biopsies, and stool. Clinical information is stored in a database and linked to specimens and data obtained from these specimens.
Research center which supports investigation of liver structure, function and disease through access to its four core facilities (Administrative, Physiology, Clinical and Translational, and Morphology cores) and Pilot Feasability Projects.
Core facility which provides comprehensive histologic and immunohistochemical support, advanced microscopic imaging and image analysis services to digestive disease researchers. The Tissue Analysis Component performs animal and human tissue embedding, sectioning, routine and special staining, and immunohistochemical analyses, and provides training in all services while the Advanced Image Analysis Component provides access to and training in routine light, fluorescent and inverted fluorescent microscopy and quantitative image analysis.
Core facility which provides DDRCC members facilitated access to technology and assistance for genetic profiling of clinical and experimental samples.