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Core that generates and distributes several kidney-specific Cre recombinase and tetracycline-inducible activator and repressor lines to be crossed to floxed or tet responder lines provided by co-investigators.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core facility that provides clinical applications and methods to make kidney research translational and applicable to care settings.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

THIS RESOURCE IS NO LONGER IN SERVICE, documented on Feb 16, 2022. Core that offers biostatistical analysis to users of the Pittsburgh Center for Kidney Research. Available to the Pittsburgh Center for Kidney Research community.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core that provides qualitative and quantitative image analysis of the kidney and lower urinary tract through performing light and electron microscopic analysis of epithelial cells and tissues, quantifying and reconstructing kidney and lower urinary tract-associated tissues and organs in 3D, and visualizing and quantifying molecular and cellular dynamics in living animals.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core that uses the yeast S. cerevisiae and the zebrafish D. rerio to dissect fundamental aspects of kidney development and protein structure and function.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core facility which provides investigators access to patients with AKI through an established international network of collaborating investigators. It also provides core resources to support the design and conduct of clinical research in AKI and genomics resources to perform systematic genomic analyses and allow correlation with clinical phenotypic information.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Center whose focus is to advance knowledge of normal kidney function, cellular mechanisms that contribute to kidney disease, and the myriad altered cellular functions that occur in the setting of renal insufficiency.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core that offers functional (in vitro microperfusion of isolated segments, measurements of transepithelial ion/solute fluxes, fluorescence functional imaging of single tubular cells), biochemical (microassays of enzyme/transporter activity), molecular (quantitation and analysis of RNA and protein), and analytical (targeted renal metabolomics of interrelated networks of small molecules) strategies applied to microdissected tubules, single cells, and urinary exosomes to address relevant questions proposed by users. It also provides analytical services for determining concentrations of exogenous pharmacological agents and molecular probes achieved within the tissue of interest.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core that provides investigators with in vitro systems for the study of transport processes at the molecular, cell, and epithelial levels.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core provides statistical expertise in the conceptualization and design of projects, expertise in data management for the resulting clinical and bioinformatics data, and assistance with the preparation of project reports, presentations and manuscripts.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Research center for kidney research, specifically acute kidney injury. It supports shared core facilities, encourages collaboration between investigators from different backgrounds and disciplines whose shared interest is in kidney research, and provides intellectual resources and infrastructure.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core facility which develops, characterizes and validates fluorescence protein biosensors for intravital multiphoton microscopy.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core that provides bioenergetics, oxidative stress analysis and metabolite analysis support for AKI research. It includes protocols and technology for bioanalytical analysis of oxidative stress and cellular bioenergetics as well as post-translational modifications.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core facility which coordinates the various activities of the center. Its various duties include facilitating interactions and collaboration among the researchers of the center, promoting scientific development through education and Pilot funding, organizing and supporting seminars, journal clubs and symposia, and maintaining communication with members.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core that provides services such as expertise in development and training in the use of rodent models of AKI, specifically in the setting of ischemia/reperfusion (I/R) injury, sepsis and renal transplantation, gamma-ray imaging (gamma camera, microSPECT/CT, microPET/CT), metabolic assessments of kidney O2 consumption, and technical expertise in isolation of primary renal and vascular cell in culture.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core facility which manages and directs the activities of the O'Brien Center, facilitates interactions and collaborations among the research base, ensures quality control of the core services and promotes scientific development and enrichment on the IU SOM campus.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core facility which develops and implements software and methods of image segmentation for fluorescence microscopy data.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core faciltiy which provides instructional workshops, a visiting speakers program, and a web resource for the dissemination of methods, educational materials and software relating to imaging technologies.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core facility which develops and characterizes methods for expressing fluorescent biosensors in the rodent kidney to be paried with intravital microscopy.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core facility which primarily provides service, animal models, consultation training and intravital optical microscopy customized to kidney and urologic research. It also develops and characterizes novel biosensor probes and in vivo delivery methods for these probes, as well as intravital multiphoton microscopy technologies.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen