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The Genome-Wide Detection of Differential Splicing Events with RNA-seq.

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• SciCrunch
• 13 years ago - by Anonymous

The Division of Acquired Immunodeficiency Syndrome (DAIDS) of the National Institute of Allergy and Infectious Diseases (NIAID) has initiated a project, in collaboration with Southern Research Institute and the National Center for Biotechnology Information (NCBI), designed to compile a comprehensive database of the described interactions between HIV-1 and cellular proteins. The goal of this project is to provide scientists in the field of HIV/AIDS research a concise, yet detailed, summary of all known interactions of HIV-1 proteins with host cell proteins, other HIV-1 proteins, or proteins from disease organisms associated with HIV/AIDS. This database has been designed to track the following information for each protein-protein interaction identified in the literature: * NCBI Reference Sequence (RefSeq) protein accession numbers. * NCBI Entrez Gene ID numbers. * Amino acids from each protein that are known to be involved in the interaction. * Brief description of the protein-protein interaction. * Keywords to support searching for interactions. * National Library of Medicine (NLM) PubMed identification numbers (PMIDs) for all journal articles describing the interaction.

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• SciCrunch
• 16 years ago - by Anonymous

Uses exome sequencing data to find copy number variants (CNVs) and genotype the copy-number of duplicated genes.

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• SciCrunch
• 13 years ago - by Anonymous

Software for accurate and fast detection of genetic variations with a novel heuristic amplicon aligner program for next generation sequencing.

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• SciCrunch
• 13 years ago - by Anonymous

The Center for Scientific Review (CSR) is the portal for NIH grant applications and their review for scientific merit. We receive all research grant applications sent to NIH and handle the review of more than 70% of those by organizing peer review groups (study sections) to evaluate research grant applications. Our mission is to see that NIH grant applications receive fair, independent, expert, and timely reviews — free from inappropriate influences — so NIH can fund the most promising research. The Center specifically: * Serves as the central receipt point for all research and training grant applications submitted to NIH. Also receives some of the applications submitted to other components of the U.S. Department of Health and Human Services (HHS) and refers them to these components; * Assigns all NIH applications to the appropriate NIH institutes or centers for consideration for funding and also to the scientific review groups within CSR or other institutes or centers for review; * Provides the scientific merit review of most research grant and fellowship applications submitted to NIH; * Provides staff support to the Office of the Director, NIH, in the formulation of grant and award policies and procedures; and * Assists other NIH components in providing information on the NIH peer review system and information about the research grant and fellowship application process and procedures to the scientific community, Congress, other NIH staff, and the general public.

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• SciCrunch
• 17 years ago - submitted by Andrea Stagg

dbRIP is a database of human Retrotransposon Insertion Polymorphisms (RIPs), in which RIPs are highly integrated into the human genome annotation data provided by UCSC Genome Browser. dbRIP contains all currently known Alu, L1, and SVA polymorphic insertion loci in the human genome. dbRIP can be used for Querying Retrotransposon Insertion Polymorphisms (RIPs), Identifying RIPs associated with particular genes, Genome-wide browsing of RIPs, Verifying newly identified retrotransposon insertions, and viewing a genome-wide view of all RIPs from one selected class or all classes (Genome plots).

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• SciCrunch
• 17 years ago - by Anonymous

The American Association of Neurological Surgeons is dedicated to advancing the specialty of neurological surgery and serving as the spokes organization for all practitioners of the specialty of neurosurgery, in order to provide the highest quality of care to our patients. :Founded in 1931 as the Harvey Cushing Society, the American Association of Neurological Surgeons (AANS) is a scientific and educational association with over 7,400 members worldwide. The AANS is dedicated to advancing the specialty of neurological surgery in order to provide the highest quality of neurosurgical care to the public. All Active members of the AANS are board certified by the American Board of Neurological Surgery, the Royal College of Physicians and Surgeons of Canada, or the Mexican Council of Neurological Surgery, A.C. Neurosurgery is the medical specialty concerned with the prevention, diagnosis, treatment and rehabilitation of disorders that affect the spinal column, spinal cord, brain, nervous system and peripheral nerves. For more information on what neurosurgeons do, visit our public pages at :<A TARGET=_blank HREF=http://www.neurosurgerytoday.org/> :<U>www.NeurosurgeryToday.orgU> :A> :<A TARGET=_blank HREF=http://www.neurosurgerytoday.org/> A> :. Visitors to our Web site can find Member Counts under membership including demographic details.

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• SciCrunch
• 17 years ago - by Anonymous

A web server and DataBase for automated Carbohydrate-active enzyme ANnotation, funded by the BioEnergy Science Center of the DOE., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025.

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• SciCrunch
• 13 years ago - by Anonymous

An integrated web server for identifying functional RNA motifs in an input RNA sequence.

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• SciCrunch
• 13 years ago - by Anonymous

An algorithm that iteratively extends long paths through a series of read-overlap graphs and evaluates them based on a statistical framework.

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• SciCrunch
• 13 years ago - by Anonymous

This database lists the G protein coupled receptors expressed endogenously in various cell lines. In so far as possible, we have tried to follow the receptor nomenclature recommended by IUPHAR. Please refer to the following web sites for additional information on receptor nomenclature: Official database of the IUPHAR committee on receptor nomenclature :http://www.iuphar-db.org/index.jsp British Journal of Pharmacology Volume 150 Issue S1 (February 2007) Guide to Receptors and channels. :http://www.nature.com/bjp/journal/vgrac/ncurrent/index.html The Endogenous GPCR List has been available in various forms since 1994 and seems to have enduring utility. We intend to continue to maintain, and when possible, improve this list. Suggestions for future enhancements are welcome. Information to be added to the database (e.g. additional endogenous receptors) is extremely welcome!

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• SciCrunch
• 17 years ago - by Anonymous

Commercial software company offering on-demand cloud, hybrid hosting, hosted private cloud, and dedicated infrastructure for complex needs.

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• SciCrunch
• 13 years ago - by Anonymous

A Matlab / Octave-based mesh generation toolbox designed for easy creation of high quality surface and tetrahedral meshes from 3D volumetric images. It contains a rich set of mesh processing scripts/programs, functioning independently or interfacing with external free meshing utilities. Iso2mesh toolbox can operate directly on 3D binary, segmented or gray-scale images, such as those from MRI or CT scans, making it particularly suitable for multi-modality medical imaging data analysis or multi-physics modeling.

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• SciCrunch
• 13 years ago - by Anonymous

Program of studies designed to assess the health and nutritional status of adults and children in the United States. The survey is unique in that it combines interviews and physical examinations.

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• SciCrunch
• 13 years ago - by Anonymous

Resource center that provides assistance for patients and families affected by Alzheimer's disease and related conditions. The Center provides patient care through the Memory and Aging Clinic as well as through research, education and service to the community. Additionally the Center provides training in dementia care, maintains centralized data collection, and sponsors programs of research that qualify for federal financial participation.

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• SciCrunch
• 15 years ago - by Anonymous

The vision of the JHU ICMIC is to combine state-of-the-art imaging capabilities with powerful molecular biology techniques to define strategies with intent to cure. It has drawn upon its human resources at JHU to create a center consisting of a multidisciplinary group of premier individuals with diverse skills focused on translating molecular capabilities into imaging possibilities with the single purpose of understanding and curing cancer. Nearly all of the investigators participating in this ICMIC have interactive collaborative projects with one or more of the other investigators. The synergism generated by the collective skills of this unique group of individuals will lead to significant advances in the understanding of cancer and its treatment. The JHU ICMIC structure consists of four interactive and closely related research components focused on hypoxia, HIF-1, and exploiting the hypoxia response element to target cancer cells through choline kinase inhibition. These research components are anchored by the participation of world renowned expertise in HIF-1. The research components utilize MR, PET and Optical Imaging technology to understand cancer vascularization, invasion and metastasis, to achieve effective cancer therapy. The center has selected developmental projects which are highly relevant to the goals of the ICMIC and interactive with the research components. Five resources devoted to adminstration, molecular biology, imaging, probes, and translational application provide the infrastructure to support the research activities of the ICMIC. Research Components in the JHU ICMIC: - Combining Anti-angiogenic therapy with siRNA targeting of choline kinase. - Imaging the Role of HIF-1 in Breast Cancer Progression - Imaging and Targeting Hypoxia in Solid Tumors - Molecular and Functional Imaging of the HER-2/neu Receptor The following are developmental projects currently taking place in ICMIC 1. Receptor imaging using nonparamagnetic MRI contrast agents (2003) 2. New imaging agents for prostate cancer (2003) 3. Non-invasive monitoring of therapeutic effect of siRNA-mediated radiation sensitization in human prostate cancer xenografts (2003) 4. Imaging of the endothelin receptor in cancer (2003) 5. Imaging studies of c-myc regulation of tumor metabolism (2003) 6. Imaging studies of anti-tumorigenic effects of anti-oxidants in vivo (2005) 7. Molecular Imaging with Magnetic Resonance Microsystems (2005) 8. Endogenous angiogenesis inhibitors (2005) 9. MR imaging and spectroscopy in detection and localization of prostate cancer: a prospective trial in patients undergoing cystoprostatectomy and radical prostatectomy. (2005) 10. A versatile visualization system for the analysis of multi-modality and multidimensional cancer imaging (2007) 11. Non-invasive imaging of CXCR4 expression in breast cancer (2007)

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• SciCrunch
• 17 years ago - by Anonymous

An acronym dictionary which can be used to find distinct expanded forms of acronyms from MEDLINE. This freely available service can be used through your browser or by integrating it with your applications using the ReSTful service. Acromine identifies abbreviation definitions by assuming a word sequence co-occurring frequently with a parenthetical expression to be a potential expanded form. Applied to the whole MEDLINE (9,635,599 abstracts), the implemented system extracted 68,007 abbreviation candidates and recognized 467,402 expanded forms. The current Acromine achieves 99% precision and 82-95% recall on our evaluation corpus that roughly emulates the whole MEDLINE.

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• SciCrunch
• 15 years ago - by Anonymous

A RNA-seq method for polyA research.

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• SciCrunch
• 13 years ago - by Anonymous

Software that manages the RNA-sequencing pipeline based on the TopHat suite of software automatically.

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• SciCrunch
• 13 years ago - by Anonymous

An open-source C/C++ library for working with human genetic variation data. The specific focus is to provide a platform for analytic tool development for variation data from large-scale resequencing projects, particularly whole-exome and whole-genome studies. However, the library could in principle be applied to other types of genetic studies, including whole-genome association studies of common SNPs. (entry from Genetic Analysis Software)

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• SciCrunch
• 14 years ago - by Anonymous