Curator Dashboard

Core that makes available PKD model systems and technologies to PKD researchers at Mayo and at other institutions. Its services include C. elegans PKD-targeted services, Zebrafish PKD-targeted services, and Rodent PKD-targeted services.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Center that focuses on understanding the causes of Cystic Kidney Disease and other related disorder and the development of new therapeutic strategies.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core whose goals include Generation of New Animal and Cell Models of HRFDs, to establish In Vivo Biosensors to Study Signaling Pathways Involved in HRFD Ciliopathies, and to generate and distribute HRFD Related Biologicals to the Center?s Investigator Base.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core whose goals are to establish a national resource for clinical data, DNA, and tissue biopsies from human patients with HRFDs, develop algorithms to identify causative genetic mutations in HRFD patients and utilize a suite of new tools to assess the pathogenicity of sequence variants, and expand the portfolio of educational information and tools to encompass the HRFD spectrum of disorders.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core services include mutation screening of cell lines derived from ADPKD patients, mutation screening of large, typical ADPKD populations, genetic screening of atypical PKD families, cystic Kidney and Liver Disease Biobank (CKLBB) from ADPKD patients, and urine collection and fractionation.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Center for the study of the development of the kidney during embryonic, fetal and postnatal life. As a collaboration between the University of Virginia and Tulane University, they use an interdisciplinary and inter-institutional approach for their research.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core that provides quantitation and identification of protein changes by 2D gel-based methods and isotope tagging and nanoLC-MS/MS, identification of protein biomarkers detected from biofluids in the Biomarker Core, and provision of dedicated and expert Biostatistical and Bioinformatic support for data analysis.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

A portal with detailed information about various research centers that focus on kidney disease and translational research funded by NIDDK.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core provides semiautomated MRI and computed tomography (CT) image and volumetric analyses of polycystic kidneys and liver as well as functional assessment of the kidney and heart, including measurements of renal blood flow. It also facilitates the transmission, collection and storage of anonymized imaging data used in translational PKD research and provides a system that enables PKD researchers to exchange images.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Center that emphasizes diagnosis, treatment and management of all types of nephrologic and hypertensive disorders in infants, children, and adolescents. Therapies range from medical management to renal replacement therapy.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Center whose goal is to support basic, translational, and clinical research on critical pediatric kidney diseases by focusing on Acute Kidney Injury, Nephrotic Syndrome, and Lupus Nephritis.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core aims include to empower the Nephrology Center of Excellence investigators by providing access to integrated state of the art gene expression technologies with which to apply genomics methods to accelerate molecular nephrology research, educate, assist, and improve the use of global genomics approaches, infrastructure and specialized tools for the enhancement of research productivity and discovery by the Nephrology Center of Excellence investigators, and develop and disseminate specialized data sets and the use of advanced analytic techniques and/or protocols to facilitate translation of research data to accelerate basic and applied research and its translation to improved clinical care.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core whose goals are to provide high throughput Clinical Biofluid Profiling Services (including initial web-based and in-person consultation, study design, sample preparation and processing, data acquisition, data analysis, protein purification, target identification, and specific assay development and validation) and services pertaining to Biomarker measurement and validation (including design of ELISA and Western Blots, measurement of known and emerging markers of acute and chronic kidney diseases, as well as consultation for biomarker statistics and clinical trials design).

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core provides services to generate unique in vivo mouse models and kidney specific cell lines.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core that provides infrastructure support for several key steps in translational research, including development of HIC protocols, patient recruitment, patient DNA extraction and archiving, tools for high throughput SNP genotyping and DNA sequencing, and analysis of genetic linkage and linkage disequilibrium.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core that provides services such as imaging of rodent kidney and heart including functional MRI, processing of tissues for routine paraffin embedding, and single tubule isolation and immunocytochemistry.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core provides specialized services and training for assessing renal function in small animals at the level of single tubules in vitro and in vivo (e.g. micropuncture, microperfusion, and tubule-specific microdissection), the whole kidney (e.g. clearance studies in anesthetized animals, perfusion fixation for histology studies), and the intact organism (e.g. balance studies in metabolic cages, acute and chronic BP measurements).

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core whose aim is to translate basic science research into effective diagnostic and therapeutic strategies that will improve the lives of patients by interrupting the pathogenesis of chronic kidney disease and its attendant high risk of cardiovascular disability and death. It combines comprehensive human genetics with phenotyping of subjects.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Center that facilitates translational and clinical research that will advance the prevention and treatment of kidney diseases.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Center whose goal is to generate new animal models to study the pathogenesis and treatment of human kidney diseases and their cardiovascular complications, accelerate the clinical application of discoveries made in renal basic science laboratories, and provide investigators with specialized tools and expertise to study kidney development, physiology, and pathophysiology.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen