Curator Dashboard

Core which provides humanized mice that enable clinically relevant in vivo studies of human cells, tissues, and immune system without putting patients at risk and expert in vivo functional analysis of transplanted human islets and stem cell-derived b-cells in immunodeficient mice that are highly valuable to the mouse research community.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core that specializes in total body/carcass analysis, measurement of oxygen consumption and carbon dioxide production, meal pattern analysis, and feeding mass/bouts, drinking volume, VO2 and VCO2.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core which provides comprehensive in vivo, ex vivo, and in vitro analysis of pancreatic function and islet structure. Its services include mouse pancreas preparation for histological experiments, surgical isolation of mouse islets, and islet structural analysis.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core that conducts specialized and non-invasive metabolic experiments to measure insulin sensitivity, glucose/lipid/protein metabolism, pancreatic beta-cell function, body composition and energy balance. Its services include access to hyperglycemic clamps to assess insulin secretion and pancreatic beta cell function in awake mice and exercise studiesl with acute, chronic endurance, and exhaustive exercise protocols and using in-house cage wheels.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core which provides services and facilities for stable, biocontainment housing, husbandry, and health care of mice. The Core manages transfer of mice from the user's institution and testing of mice for the quarantine process.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Research center that provides metabolic and physiologic phenotyping services for mouse models of diabetes, diabetic complications, obesity and related disorders. It specializes in the immunological aspects of Type I diabetes, measurement of various glucose and lipid metabolism parameters relevant to Type II diabetes as well as diabetic complications such as heart disease and obesity.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

UMass Metabolic Disease Research Center (MDRC), formerly the National Mouse Metabolic Phenotyping Center, is a core facility that performs standardized experiments using state-of-the-art equipment for the purpose of investigating transgenic mouse models of diabetes, obesity, and metabolic liver disease. Provides metabolic and functional characterization of mouse models of human diseases that are developed by academic and industry researchers in joint efforts to understand metabolic diseases and to identify new therapies.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core that provides analysis of hormones, cytokines, chemokines, metabolites, and electrolytes across multiple platforms (serum, tissues, homogenates, and cells) as well as liver function analysis through instrumentation.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core that provides investigators with services to accurately measure the major components of energy balance in their mouse models and tests that allow investigators to examine physiological factors that may influence food intake or energy expenditure.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core that provides services based on the testing and analysis of fat lipids, intestinal lipid absorption, and cholesterol in tissues.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core responsible for oversight and coordination of all aspects of the scientific and administrative operations of the MMPC-UCD. This includes providing full customer support services, overseeing management and operation of the Center, and foster interactions and synergism among cores and research projects. The ultimate goal of the Core is to ensure that the Center effectively and efficiently delivers services to its users.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core that offers measurement of gut permeability, plasma lipopolysaccharide binding protein (LBP) assay, and inflammatory profiling.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core that offers services in testing animal physiological variables such as blood pressure, heart rate, pulse pressure and activity after inserting a PA-C10 telemetry device in them.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core that provides phenotyping services for the assessment of endocrine function and metabolic pathways in mouse models of obesity, diabetes, and related metabolic diseases including dyslipidemia and fatty liver disease.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Organization whose mission is to advance medical and biological research by providing the scientific community with standardized, high quality metabolic and physiologic phenotyping services for mouse models of diabetes, diabetic complications, obesity and related disorders.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Center that provides the scientific community with metabolic and physiologic phenotyping tests, services, and procedures for mouse models of diabetes, diabetic complications, obesity and related disorders in order to advance medical and biological research.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core that provides importation/exportation, colony management, customized mouse models, rederivation and creation of genetically-modified mutant mice (e.g. CRISPR), and re-animation of a variety of models cryopreserved within the KOMP or MMRRC repositories. It also provides ancillary services and procedures, including blood sampling for in vivo testing for glucose tolerance tests and insulin tolerance tests.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Zebrafish core facility which generates and maintains transgenic and mutant fish lines for hematology research. It also provides expertise and training in model production, study design, and fish production for research.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core whose services include in vivo physiological assessments encompassing glucose homeostasis (glucose tolerance, insulin tolerance, hyperinsulinemic/euglycemic clamps), energy homeostasis (indirect calorimetry by CLAMS, dietary challenge), ultradian hormone secretion (Culex platform for serial biological fluid sampling from unrestrained mice), behavioral measurements (locomotor activity, meal pattern analysis, operant conditioning) and generation of bariatric surgery models.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on July 6th,2023. Core whose objective is to provide investigators at Vanderbilt and outside institutions a means to accurately assess cardiovascular phenotypes in mouse models of diabetes and metabolic disease. The CPC uses validated approaches and state-of-the-art instrumentation that allow for sensitive screening of phenotypic variations.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen