Curator Dashboard

Research center that maintains core facilities available for studies of cell biology, ion transport, and translational aspects of cystic fibrosis research.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core whose services include biospecimen collection and storage, development of lung imaging outcomes, imaging training, and biostatical analysis.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core that provides advanced digital light microscopy, image processing and analysis resources for users from the UNC Chapel Hill campus. It also offers instrumentation and instruction to enable users to acquire, process and analyze images from a wide variety of sample types.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core that provides support and expertise for mouse colony maintenance, breeding strategies, mouse lung phenotyping protocols, and submission of live-animal applications to maintain compliance with IACUC guidelines.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Research team dedicated to finding a cure for cystic fibrosis lung disease. This team utilizes ion transport physiology, transgenic and gene-targeted mouse models, Phase I clinical trials, and more to research this cause.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core whose objectives include evaluation of pre-clinical drug candidates in vitro, pre-clinical drug candidates ex vivo, and pre-clinical drug candidates in vivo.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core that analyzes ion channel properties and correction efficiency of human bronchial epithelial (HBE) cells from harvested CF lungs to provide a full characterization report to investigators, measures ion transport function of CFTR and ENaC in HBE and human nasal epithelial (HNE) cultures by bioelectric and organoid assays to asses efficacy of candidate therapies, evaluates CFTR expression and processing by biochemical analyses to assess efficacy of CFTR modulation strategies, and validates the suitability of reagents, supplies, and techniques for optimizing HBE and HNE cell integrity.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core that provides light microscopy services like prosection, tissue fixation, processing, embedding, sectioning, staining and cover slipping of paraffin, frozen and soft plastic tissue sections, as well as specialized and routine fixation, tissues processing, ultramicrotomy, staining, photomicrograph production, and analysis.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core facility that provides expertise, equipment, training, and reagents to serve the molecular biology needs for cystic fibrosis research.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Research centers that provide support for basic, preclinical, and clinical research efforts to advance scientific knowledge and new therapies for cystic fibrosis.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Microscope that can visualize multiple nuclear, cytoplasmic and membrane markers in the same tissue section and with intact morphology. Its features include detection and measurement of weakly expressed and overlapping biomarkers in fixed tissue sections, autofluorescence removal technology, and the ability to work with both fluorescence and brightfield samples.

• Resource
• RRID-Legacy
• 10 years ago - by Anonymous

Software that fits s-shaped psychometric functions to psychophysical data using a maximum-likelihood technique. The psychometric functions available are logistic, Weibull, Gaussian integral, cumulative Poisson and step. PsychoFit produces, among other things, files with graphic information suitable for importing in a graphic program for plotting., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025.

• Resource
• RRID-Legacy
• 10 years ago - by Anonymous

Core that ensures the health and welfare of mouse models by assuring that mice admitted to the MMPC meet defined health criteria and that post-quarantine protocol assignment. It diagnoses disease and identifies unique metabolic or cardiovascular phenotypes of mice through interaction with the Comparative Pathology Subcore.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core that consists of three subcores: Hormone Assay and Analytical Services, Lipids, Lipoproteins, and Atherosclerosis, and Mouse Pathology. The Hormone Assay and Analytical Services provides analyses that facilitate research in diabetic, cardiovascular, and obese animal models. Lipids and Lipoproteins Subcore provides quantitative and qualitative measurements of plasma and tissue lipids and lipoproteins to researchers who use mice to study atherosclerosis, dyslipidemia, diabetes, obesity, hypertension, and other metabolic diseases. Mouse Pathology services include standard pathology testing in hematology, clinical chemistry, parasitology, microbiology, serology, molecular diagnostics, necropsy, and research histology and pathology expertise and counseling.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on April 16,2025. Core whose mission is to provide analytical tools to investigators to permit determination of the structure of the microbiome in mouse models of disease and assistance in the cultivation of microbes that will permit hypothesis testing in murine models including the germfree animals that are available in the Animal Care Core.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core whose services include determining the components of energy balance with high precision and time resolution, providing robust imaging technology to monitor the dynamics of cellular process, and providing innovative mouse bariatric surgery models with application to basic and translational research.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core which provides a complete range of microvascular phenotyping of murine models of diabetes, obesity and metabolic disease, including validated, reproducible and standardized phenotyping of the three major microvascular complications: diabetic polyneuropathy, nephropathy and retinopathy.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core that provides phenotyping of cardiovascular system in mouse models of metabolic disease and an easily accessible cardiovascular disease model pipeline. It services include 2D and M-mode echocardiography in lightly-anesthetized mice to non-invasively assess cardiac structure and function using state-of-the-art high-frequency, high-resolution in vivo digital imaging platform as well as Transverse Aortic Constriction (TAC) model to investigate pressure-overload hypertrophy, congestive heart failure, and aortic stenosis.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Research center whose mission is to advance research in the area of diabetes by providing experimental tools to the scientific community for phenotyping mouse transgenic models of diabetes and related disorders.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Research center which aims to contribute to a national database of metabolic phenotyping data in wild-type mouse strains and a broad range of mouse models relevant to the pathogenesis and treatment of diabetes, obesity and associated metabolic disorders. It also aims to foster continued technical development, refinement of assay sensitivity and specificity, data reproducibility, and transmission of best research practices within the areas of fundamental and applied diabetes and obesity research.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen