Curator Dashboard

Research center which provides access to core facilities and services to aid gene therapy researchers.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core facility which provides comprehensive necropsy, histology, and pathology services for animal models in order to facilitate translational research in animal models of cystic fibrosis. It also houses instrumentation which allows for high-throughput optimization of immunostaining protocols and has access to morphologic equipment that allow for the scanning of large tissue areas and morphometric quantification of histologic endpoints.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core that provides centralized access to non-cystic fibrosis and cystic fibrosis tissue specimens and airway cells used for model systems to assess gene transfer to the airway and pathophysiology in cystic fibrosis.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core facility which provides a variety of assay services to evaluate cell-mediated and humoral responses to in animal models of gene therapies.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core that manages and oversees the UW CFRTC and its cores and pilot and feasibility programs.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core that provides Ussing chamber capabilities and expertise for testing vectoral anion transport in polarized airway epithelial monolayers, and florescent dye-based methods for evaluating CFTR activity in cells grown on coverslips. The core also performs immunolocalization for proteins relevant to cystic fibrosis pathogenesis.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Research center whose focus is on developing effective gene vectors derived from recombinant viruses. Much of their research is in the development of new adeno-associated virus (AAV) vectors, although some of their research involves both adenoviruses and lentiviruses.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core whose objective is to obtain information on relevant parameters of the host response that is unique to cystic fibrosis using a variety of techniques, including in vivo and in vitro imaging, immunohistochemistry, imaging and image analysis, cells and bacteria in tissues, and quantification of chemokines, cytokines, and other factors with ELISA.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core provides genomics-based tools, data management and analysis tools, and creates platforms that integrate data from the Clinical and Immunology Cores for human samples and bacterial isolates. Services include consultation and experimental design assistance for using new-generation sequencing technology, data analysis, bioinformatic support, data access and storage, high throughput and new-generation whole-genome sequencing, and RNA-seq analysis of transcriptomes.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core facility which provides tools, reagents, and training for microbiological researchers investigating cystic fibrosis. They specifically provide resources for research in anti-bacterial therapies,

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core that aims to provide preclinical support for novel therapeutics, work with other biomedical cores to enhance and support bacterial and human specimen repositories, and support developmental research and training.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Research center that aims to provide resources and expertise to expedite development of potential new therapeutic approaches to correct dysfunctional CFTR and its secondary consequences, enhance understanding of evolving bacterial ecosystems and resultant host response in CF gastrointestinal and respiratory tracts, and how these interactions impact health. It also aims to develop improved assays, new drug screening assays, biomarkers and improved clinical outcome measures, as well as to better understand the metabolic and inflammatory consequences of CFTR dysfunction.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Research center whose goal is to understand and translate the basic mechanisms of cystic fibrosis. It uses the molecular and cell biology of CFTR, CFTR mutants, infection, and inflammation with the overall theme of translating preclinical science into clinical investigations.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core that provides human primary nasal airway epithelial cells and bronchial airway epithelial cells, expertise in the nasal potential difference measurement, and a means to understand pathogenesis of cystic fibrosis and other metabolic diseases.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Research center that focuses on developing novel therapies for cystic fibrosis, enhancing research projects examining the mechanisms of the disease, and developing new small-molecule therapies that can be translated into the clinic.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core that maintains a repository of reagents for studying CFTR and assists with expression technologies using vaccinia, adenovirus and other methodologies and antibody based detection of cystic fibrosis related gene products.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core that assists in mouse line generation by both oocyte micro-injection and by embryonic stem cell gene targeting technologies. It also establishes breeding colonies of cystic fibrosis mice, and genotypes and provides these to UAB investigators and furnishes electrophysiology tests of CFTR activation, including murine nasal potential difference assays and intestinal short circuit current measurements.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core that assists with patch clamp and single channel analysis relevant to ion channel gating. The core also provides primary murine airway epithelial cells.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core that provides standardized cell cultures for cystic fibrosis research, notably normal, cystic fibrosis and disease control cells, tissues and fluids. Its functions include tissue procurement, airway epithelial cell isolation and culture, collecting airway surface liquid from in vivo and in vitro samples, genetic manipulation of cell cultures, creating and characterizing novel cell lines, and translation of technology and reagents to the greater cystic fibrosis research community.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core that provides a service to quantify the concentration of given mucus samples for both total mucus concentration and the absolute relative contributions of each secreted mucin. It also provides quantitation of extracellular DNA. The mucus biphysics subcore component, provides core users with information on the biophysical properties of the mucus layer and its interaction with the cell surface.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen