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Core that provides investigators with access to adipose tissue samples from well-characterized subjects. It also assists investigators with analysis of adipose tissue morphology and metabolism, specialized cell and organ culture methods, and analysis of gene and protein expression.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core that facilitates the conduct of clinical nutrition and obesity research. Its team of experts in nutrition, exercise physiology, body composition, metabolism and behavioral therapy aim to assist and train NORCH investigators in the skills necessary to conduct clinical nutrition and obesity research.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Center that fosters multidisciplinary research approaches to understanding the impact of nutrition on risk for chronic disease and aims to translate this knowledge into effective clinical treatments and prevention efforts.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core that provides NORCH investigators with access to model creation and detailed metabolic phenotyping. Its services include: model generation, including genomic targeting and production of metabolically relevant cell types; metabolic characterization of patient-derived, user-provided, or model generated samples; consultation on model development and metabolic characterization projects; and training for Core techniques in model generation and detailed metabolic characterization.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core that provides consultations for study design and analysis, preparation of grant applications, preparation of statistical methods and results for manuscripts on completed studies, responses to reviewer comments for manuscript resubmissions, identification of possible long term statistical collaborators for grants.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core that facilitates the application of genomics, bioinformatics, cell biology, and immunology techniques to nutrition and metabolic research.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core that links a variety of imaging facilities providing services to NORCH investigators who currently require or plan to conduct human studies using imaging research instrumentation and expertise. Its goal is to provide users with access to imaging technology for in-vivo phenotyping of human tissues for nutrition, obesity and metabolism studies.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core that provides administrative support and direction to all of the participating institutions and BNORC members. These services include financial management, payment requests, policy development and data management.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core that supports and coordinates the NORCH and all the components of the center. It provides insight into the processes that govern the center, to recruit and vet new members, and to communicate with all our members about center happenings.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core provides services to investigators within BNORC and the Boston area looking to expand their research using state-of-the-art genomic applications. This core utilizes technologies and sequencing platforms to help identify the complex molecular mechanisms underlying human disease.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Research center at Harvard University that seeks to establish a research environment which encourages the approach to defining common clinical nutrition research problems. It aims to promote, facilitate and enhance research relating to nutrition and health within the Boston area.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core that provides a central focus to translate the findings from clinical and cellular studies to applications in ongoing epidemiologic studies.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Center that is organized to address cross-cutting themes that represent gaps in understanding the relationship between nutrition and health, and the pathogenesis of obesity and its associated metabolic diseases.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core that facilitates and fosters research on mechanisms regulating white, brite or beige and brown adipose tissue mass, distribution, nutrient signaling and depot-specific metabolic and endocrine functions in health and disease.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Research center that aims to understand the causal factors underlying nutrition and obesity-related health problems and the generation and evaluation of evidence on their consequences, prevention, and alleviation.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core facility which provides support to cystic fibrosis investigators in gene transfer technologies through consultation, development of novel vectors, collaborative testing of vectors for function and purity, and routine vector preparations.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core facility which provides a range of technologies for morphologically based studies and technically more complex support in the detection of transgenes and transgene products using techniques of in situ hybridization and immunohistochemistry.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core facility which aims to provide cystic fibrosis researchers with a biobank of archived biosamples collected during routine clinical visits and research-related visits. Biospecimens include normal and CF specimens including DNA, bronchoalveolar lavage fluid, whole blood, plasma, feces, urine, and bacterial isolates. It also aims to facilitate patient recruitment and enrollment in clinical trials.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core that allows investigators to efficiently and cost effectively define the phenotypes of small rodents in ways that are relevant to the study of obesity, nutrition, and metabolism. Its services range from whole animal measurements of body composition and energy utilization, to ex vivo measurements of substrate fluxes, to histological analyses of adipose tissue.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core that provides support to investigators who use animal models to study the pathogenesis of cystic fibrosis and who develop gene and other molecular therapies for cystic fibrosis. Specifically, it provides centralized production, care, breeding, genotyping, and quality control of cystic fibrosis mouse and ferret models used by investigators in the Center.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen