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Mobile simulation app for visualizing molecular interactions in liquids, solids and gases. The simulations are performed with the molecular dynamics code LAMMPS.
Core whose focus is on modern approaches to the study of the human immune system and their application to the study of IBD and related disorders. Its services include routine immunology tools, specialized immunology services, and education and training services.
Core whose services include breeding and maintenance of mutant mouse stocks, characterization of murine models, bone marrow transfers and adoptive T cell transfers, in vivo tracking of fluorescently labeled bacteria and cells, and whole body imaging of bioluminescent and fluorescent signals.
Center whose goal is the facilitation and fostering of interdisciplinary collaborative research in the field of pathobiology of diseases of the liver and digestive tract and the development of new treatments for these diseases.
Core that provides standard and customized slide preparation, liver histochemistry and immunohistochemistry as well as laser-capture microscopy.
THIS RESOURCE IS LONGER IN SERVICE. Documented on June 15,2026. Management core whose main functions include organizing and managing membership committees, coordinating communication with the NIH and other research bases, and overseeing the use of funds.
Core that provides instrumentation (confocal and fluorescence microscopy) and technical support for cell biology and pathophysiology studies.
Core facility which provides primary hepatocytes cultures of normal and diseased mice and rats and various cell lines to investigators. The cell separation subcore plays a role in translational research in DILI and alcoholic hepatitis, supporting funded studies of the role of innate and adaptive immune systems in elucidating pathophysiology, identifying biomarkers, and predicting response to treatments.
Core that maintains and provides access and training in the use of a large base of major and expensive equipment, including thermocyclers, plate readers, centrifuges, a wide range of customized HPLC services, and Seahorse metabolic applications.
Management core that develops mission, goals, and strategies relating to the functioning of the CURE:DDRCC.
Core facility whose services include consultion for further dissemination of diabetes research and assistance with design methods for early dissemination of results.
Core facility which supports faculty research by facilitating access to human biospecimens. Its services include centralized access to participating Mayo Clinic GI biobanks and other institutional biospecimen resources, de-identified, phenotypic and demographic data, and coordination of fresh tissue acquisition from surgical pathology.
Core that provides CSIBD investigators with the technical support, expertise and access to instrumentation necessary for their morphological and cell biological studies related to IBD. These services include routine tissue fixation and processing for light microscopy, imaging flow cytometry, perfusion-fixation of organs, conventional electron microscopy, low temperature embedding in Lowicryl HM20, and immunocytochemistry.
Core whose objective is to provide an infrastructure that facilitates the translation of basic research findings into the clinic. Its services include consultation, training, and education, biospecimen services, and facilitating data collection and analysis.
Core whose services include designing, constructing and validating custom plasmids and other DNA vectors, making custom genome engineering reagents, including TALENs, transposons, bacterial artificial chromosomes and CRISPRs, and providing consults and training on a variety of topics, including rodent and zebrafish transgenic and knockout model development support.
Center whose objectives include promoting digestive diseases-related research in an integrative, collaborative and multidisciplinary manner, developing and implementing programs for attracting, training, and retaining young investigators in digestive disease-related research, and facilitating the transfer of basic research discoveries to improvements in prevention and/or clinical care.
Center whose mission is to improve understanding of the signaling pathways that control the function of gastrointestinal cells in health and disease. It serves as a hub that provides access to research resources and expertise to multidisciplinary groups of basic scientists and clinical researchers.
Core that aims to further digestive disease research by providing services including identification of oxidized lipids by GC/MS and HR-LC/MS, proteomics for identification and characterization of proteins by MudPIT and LC-MS/MS techniques, quantification of protein expression by LC-MS/MS, interpretation and analysis of mass spectrometry data, and quantification of trace elements in physiologic fluids by ICP-MS.
Core that provides governance, financial and operational management, and strategic planning functions for the DDC. This core is also responsible for coordinating the annual Pilot Feasibility Awards program, as well as the weekly GI Research Forum and the annual Frontiers in Digestive Medicine Symposium.
THIS RESOURCE IS NO LONGER IN SERVICE. Documented on June 30,2023. Core facility that provides support to investigators in designing and carrying out translational studies assessing outcomes for patients with diabetes, or populations at risk.