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THIS RESOURCE IS NO LONGER IN SERVICE. Documented on June 15,2026. Core facility that provides advice and technical services to DDRCC investigators that include production of transgenic and chimeric mice, derivation of speed congenics and assisted reproduction services for maintaining pedigrees via the Mouse Genetics Core, as well as gnotobiotic mouse provision, colonization and rederivation.
Core facility which aims to develop an infrastructure for patient-oriented research by streamlining regulatory and compliance processes, obtaining and storing high-quality samples linked to clinical information, offering consultation in the design and implementation of clinical trials, and supplying statistical expertise for interpreting clinical and translational data.
Core facility that provides technical expertise, equipment and personnel to Liver Center Investigators who wish to work with animal models of liver disease, isolated liver cells, or gene expression in liver tissue. The Cell Isolation sub-core isolates hepatocytes and non-parenchymal liver cells primarily from rat and mouse, while the Molecular Biology sub-core provides equipment and expertise to Liver Center members in a centralized facility.
Core facility which acts as the administrative structure of the Liver Research Center. The activities it oversees include all scientific and administrative supervisory functions of the Center and its administrative leadership, including the organization and supervision of Core facilities, the planning and scheduling of the enrichment program and the review and oversight of individual pilot feasibility projects.
Core facility that collects and provides specimens and longitudinal clinical data from patients with digestive diseases. Specimens collected and processed by the core currently include blood, surgical resections, endoscopic biopsies, and stool. Clinical information is stored in a database and linked to specimens and data obtained from these specimens.
Research center which supports investigation of liver structure, function and disease through access to its four core facilities (Administrative, Physiology, Clinical and Translational, and Morphology cores) and Pilot Feasability Projects.
Core facility which provides comprehensive histologic and immunohistochemical support, advanced microscopic imaging and image analysis services to digestive disease researchers. The Tissue Analysis Component performs animal and human tissue embedding, sectioning, routine and special staining, and immunohistochemical analyses, and provides training in all services while the Advanced Image Analysis Component provides access to and training in routine light, fluorescent and inverted fluorescent microscopy and quantitative image analysis.
Core facility which provides DDRCC members facilitated access to technology and assistance for genetic profiling of clinical and experimental samples.
Research center whose purpose is to advance research in digestive disease with a focus on interactions between host and environment. It provides research resources to basic and translational investigators through various core facilities.
Core facility whose services include training, acquisition and analysis on cytometers for experiments that include different fluorochromes, imaging cytometry, and mass cytometry.
Core facility whose goals include furnishing professional guidance in experimental design and data interpretation and providing access to optical and electron microscopy. Its services include confocal microscopy, wide-field microscopy, transmission electron microscopy, and processing and embedment of tissue or cells for EM.
Software toolkit for data aquisition and analysis. Its features include remote control of Abberior Instruments microscopes via a Python/MATLAB script, third-party compatibility with other data-analysis softwares/methods, and the easyCommander graphical user interface for experimental set up.
Data analysis and visualization software with features that include a R interface, demographic maps, bivariate density estimation, multiple time series visualization, repeated ANOVA measures, and a multivariate visualizers.
Web software capable of scanning large-scale sequences for full-length LTR retrotranspsons., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025.
Tool for interactive image classification, segmentation and analysis, built as a modular software framework, which currently has workflows for automated (supervised) pixel- and object-level classification, automated and semi-automated object tracking, semi-automated segmentation and object counting without detection.
Software suite that provides an efficient way for scientist with minimal knowledge of computers to create anatomical maps and integrate this information with behavioral and physiological data for sharing on the web. It uses R for data analysis and graphical plotting and uses OpenCV for image analysis., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025.
Software tool used to carry out statistical selection of best-fit models of nucleotide substitution without the aid of PAUP*. It implements five different model selection strategies: hierarchical and dynamical likelihood ratio tests, Akaike and Bayesian information criteria, and a decision theory method. It also provides estimates of model selection uncertainty, parameter importances, and model-averaged parameter estimates.
Interactive web visualization tool for populations of bacterial genomes linked by a phylogeny.
Data standard for neurophysiology, providing common standard to share, archive, use, and build common analysis tools for neurophysiology data. NWB:N is designed to store variety of neurophysiology data, including data from intracellular and extracellular electrophysiology experiments, data from optical physiology experiments, and tracking and stimulus data. Project includes NWB format and broad range of software for data standardization and application programming interfaces (APIs) for reading and writing data as well as high value data sets that have been translated into NWB data standard. NWB format is implemented in Hierarchical Data Format (HDF5) and is designed to store data in self documenting way. Storage schema is described by specification language and it is extensible to support future scientific needs as well as lab specific requirements.
Simulator to help students understand basic properties of excitable membranes, particularly ion flow across an excitable membrane. The simulator is based on the equations developed by Alan Hodgkin and Andrew Huxley following their research on the excitability properties of the squid giant axon.