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Core that provides bioenergetics, oxidative stress analysis and metabolite analysis support for AKI research. It includes protocols and technology for bioanalytical analysis of oxidative stress and cellular bioenergetics as well as post-translational modifications.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core facility which coordinates the various activities of the center. Its various duties include facilitating interactions and collaboration among the researchers of the center, promoting scientific development through education and Pilot funding, organizing and supporting seminars, journal clubs and symposia, and maintaining communication with members.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core that provides services such as expertise in development and training in the use of rodent models of AKI, specifically in the setting of ischemia/reperfusion (I/R) injury, sepsis and renal transplantation, gamma-ray imaging (gamma camera, microSPECT/CT, microPET/CT), metabolic assessments of kidney O2 consumption, and technical expertise in isolation of primary renal and vascular cell in culture.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core facility which manages and directs the activities of the O'Brien Center, facilitates interactions and collaborations among the research base, ensures quality control of the core services and promotes scientific development and enrichment on the IU SOM campus.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core facility which develops and implements software and methods of image segmentation for fluorescence microscopy data.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core faciltiy which provides instructional workshops, a visiting speakers program, and a web resource for the dissemination of methods, educational materials and software relating to imaging technologies.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core facility which develops and characterizes methods for expressing fluorescent biosensors in the rodent kidney to be paried with intravital microscopy.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core facility which primarily provides service, animal models, consultation training and intravital optical microscopy customized to kidney and urologic research. It also develops and characterizes novel biosensor probes and in vivo delivery methods for these probes, as well as intravital multiphoton microscopy technologies.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core facility which investigates the connections between chronic kidney disease, cardiovascular disease, and hypertension. It focuses specifically on investigating the pathophysiology, epidemiology, and therapeutic response in on-going studies or existing datasets of one of the three diseases with the aim of relating data from individual diseases to each other.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Imaging center which provides renal and urological researchers access to intravital optical microscopy and 3-dimensional quantitative digital image analysis.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Research program whose aim is to make state-of-the art technologies and resources accessible to a broad spectrum of investigators pursuing studies in kidney research areas.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core facility that provides resources for investigators researching the genetic mechanisms of chronic kidney disease, cardiovascular disease, and hypertension. Its services include pre-study consultation, standardized services for DNA isolation and storage, and assisstance in carrying out molecular genetic studies.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Research center which investigates the mechanisms underlying the impact kidney disease has on cardiovascular morbidity and mortality using genetic and basic science approaches.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core facility that provides access to a range of experimental models of kidney, heart and vascular diseases. It also provides comprehensive phenotyping services for kidney functions, blood pressure and other cardiovascular functions.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core that provides measurement of serum and or urine Creatinine by Capillary Electrophoresis, measurement of serum and urine citrate by capillary electrophoresis, Microanalysis of serum and urine electrolytes by: Flame photometry, Atomic absorption or Ion-Selective Electrode, and Klotho IP-IB Assay.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core that provides both morphological analysis of mucosal tissues and instructs investigators in the techniques used to prepare tissue sections and analyze the morphology and cellular components of the mucosa and primary human gut (intestinal and rectal) cells, gastric mononuclear cells and genital (cervical and vaginal) cells and instruction on how to construct mucosal tissue explants in a transwell chamber system.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core facility that provides instrumentation and technical expertise for the preparation, acquisition and analysis of images of cells and tissues at the light microscopic level. Its services include confocal and super-resolution microscopy, epifluorescent microscopy with quantitative and ratio imaging, timelapse microscopy with image processing and analysis, multiphoton microscopy, and cryosectioning.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core facility which generates and provides gnotobiotic and genetically engineered mice to research projects. It also provides specialized breeding, marker-assisted genotyping, and histopathologic evaluation services for studies using these mice.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core composed of the Viral Unit, which provides labeled andn unlabeled viral components, and Bacterial Unit, which provides bacteria and bacterial proteins for research. The retroviral unit focues on the viral components of the retrovirus HIV-1.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Research center which investigates the interaction between microbes and mucosal tissues in humans. It provides three core facilities for research: the Genetically-Defined Microbe Core, the Molecular Pathology and Human Cell/Tissue Core, and the Gnotobiotic and Genetically-Engineered Mouse Core.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen