Curator Dashboard

Core whose goals are to provide high throughput Clinical Biofluid Profiling Services (including initial web-based and in-person consultation, study design, sample preparation and processing, data acquisition, data analysis, protein purification, target identification, and specific assay development and validation) and services pertaining to Biomarker measurement and validation (including design of ELISA and Western Blots, measurement of known and emerging markers of acute and chronic kidney diseases, as well as consultation for biomarker statistics and clinical trials design).

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core provides services to generate unique in vivo mouse models and kidney specific cell lines.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core that provides infrastructure support for several key steps in translational research, including development of HIC protocols, patient recruitment, patient DNA extraction and archiving, tools for high throughput SNP genotyping and DNA sequencing, and analysis of genetic linkage and linkage disequilibrium.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core that provides services such as imaging of rodent kidney and heart including functional MRI, processing of tissues for routine paraffin embedding, and single tubule isolation and immunocytochemistry.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core provides specialized services and training for assessing renal function in small animals at the level of single tubules in vitro and in vivo (e.g. micropuncture, microperfusion, and tubule-specific microdissection), the whole kidney (e.g. clearance studies in anesthetized animals, perfusion fixation for histology studies), and the intact organism (e.g. balance studies in metabolic cages, acute and chronic BP measurements).

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core whose aim is to translate basic science research into effective diagnostic and therapeutic strategies that will improve the lives of patients by interrupting the pathogenesis of chronic kidney disease and its attendant high risk of cardiovascular disability and death. It combines comprehensive human genetics with phenotyping of subjects.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Center that facilitates translational and clinical research that will advance the prevention and treatment of kidney diseases.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Center whose goal is to generate new animal models to study the pathogenesis and treatment of human kidney diseases and their cardiovascular complications, accelerate the clinical application of discoveries made in renal basic science laboratories, and provide investigators with specialized tools and expertise to study kidney development, physiology, and pathophysiology.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core that generates and distributes several kidney-specific Cre recombinase and tetracycline-inducible activator and repressor lines to be crossed to floxed or tet responder lines provided by co-investigators.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core facility that provides clinical applications and methods to make kidney research translational and applicable to care settings.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

THIS RESOURCE IS NO LONGER IN SERVICE, documented on Feb 16, 2022. Core that offers biostatistical analysis to users of the Pittsburgh Center for Kidney Research. Available to the Pittsburgh Center for Kidney Research community.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core that provides qualitative and quantitative image analysis of the kidney and lower urinary tract through performing light and electron microscopic analysis of epithelial cells and tissues, quantifying and reconstructing kidney and lower urinary tract-associated tissues and organs in 3D, and visualizing and quantifying molecular and cellular dynamics in living animals.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core that uses the yeast S. cerevisiae and the zebrafish D. rerio to dissect fundamental aspects of kidney development and protein structure and function.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core facility which provides investigators access to patients with AKI through an established international network of collaborating investigators. It also provides core resources to support the design and conduct of clinical research in AKI and genomics resources to perform systematic genomic analyses and allow correlation with clinical phenotypic information.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Center whose focus is to advance knowledge of normal kidney function, cellular mechanisms that contribute to kidney disease, and the myriad altered cellular functions that occur in the setting of renal insufficiency.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core that offers functional (in vitro microperfusion of isolated segments, measurements of transepithelial ion/solute fluxes, fluorescence functional imaging of single tubular cells), biochemical (microassays of enzyme/transporter activity), molecular (quantitation and analysis of RNA and protein), and analytical (targeted renal metabolomics of interrelated networks of small molecules) strategies applied to microdissected tubules, single cells, and urinary exosomes to address relevant questions proposed by users. It also provides analytical services for determining concentrations of exogenous pharmacological agents and molecular probes achieved within the tissue of interest.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core that provides investigators with in vitro systems for the study of transport processes at the molecular, cell, and epithelial levels.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core provides statistical expertise in the conceptualization and design of projects, expertise in data management for the resulting clinical and bioinformatics data, and assistance with the preparation of project reports, presentations and manuscripts.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Research center for kidney research, specifically acute kidney injury. It supports shared core facilities, encourages collaboration between investigators from different backgrounds and disciplines whose shared interest is in kidney research, and provides intellectual resources and infrastructure.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core facility which develops, characterizes and validates fluorescence protein biosensors for intravital multiphoton microscopy.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen