SciCrunch

Cystic Fibrosis Center University of Pittsburgh

Research center whose goal is to understand and translate the basic mechanisms of cystic fibrosis. It uses the molecular and cell biology of CFTR, CFTR mutants, infection, and inflammation with the overall theme of translating preclinical science into clinical investigations.

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SciCrunch
10 years ago - submitted by Kristen Jensen

Gregory Fleming James Cystic Fibrosis Research Center Cystic Fibrosis Clinical and Translational Core

Core that provides human primary nasal airway epithelial cells and bronchial airway epithelial cells, expertise in the nasal potential difference measurement, and a means to understand pathogenesis of cystic fibrosis and other metabolic diseases.

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SciCrunch
10 years ago - submitted by Kristen Jensen

Cystic Fibrosis Center - University of California San Francisco

Research center that focuses on developing novel therapies for cystic fibrosis, enhancing research projects examining the mechanisms of the disease, and developing new small-molecule therapies that can be translated into the clinic.

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SciCrunch
10 years ago - submitted by Kristen Jensen

Gregory Fleming James Cystic Fibrosis Research Center Cystic Fibrosis Transmembrane Conductance Regulator Expression Core

Core that maintains a repository of reagents for studying CFTR and assists with expression technologies using vaccinia, adenovirus and other methodologies and antibody based detection of cystic fibrosis related gene products.

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SciCrunch
10 years ago - submitted by Kristen Jensen

Gregory Fleming James Cystic Fibrosis Research Center Cystic Fibrosis Animal Models Core

Core that assists in mouse line generation by both oocyte micro-injection and by embryonic stem cell gene targeting technologies. It also establishes breeding colonies of cystic fibrosis mice, and genotypes and provides these to UAB investigators and furnishes electrophysiology tests of CFTR activation, including murine nasal potential difference assays and intestinal short circuit current measurements.

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SciCrunch
10 years ago - submitted by Kristen Jensen

Gregory Fleming James Cystic Fibrosis Research Center Cell Model and Evaluation Core

Core that assists with patch clamp and single channel analysis relevant to ion channel gating. The core also provides primary murine airway epithelial cells.

Resource
SciCrunch
10 years ago - submitted by Kristen Jensen

Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center Tissue Procurement and Cell Culture Core

Core that provides standardized cell cultures for cystic fibrosis research, notably normal, cystic fibrosis and disease control cells, tissues and fluids. Its functions include tissue procurement, airway epithelial cell isolation and culture, collecting airway surface liquid from in vivo and in vitro samples, genetic manipulation of cell cultures, creating and characterizing novel cell lines, and translation of technology and reagents to the greater cystic fibrosis research community.

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SciCrunch
10 years ago - submitted by Kristen Jensen

Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center Mucus and Mucin Biochemistry and Biophysics Core

Core that provides a service to quantify the concentration of given mucus samples for both total mucus concentration and the absolute relative contributions of each secreted mucin. It also provides quantitation of extracellular DNA. The mucus biphysics subcore component, provides core users with information on the biophysical properties of the mucus layer and its interaction with the cell surface.

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SciCrunch
10 years ago - submitted by Kristen Jensen

Gregory Fleming James Cystic Fibrosis Research Center

Research center that maintains core facilities available for studies of cell biology, ion transport, and translational aspects of cystic fibrosis research.

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SciCrunch
10 years ago - submitted by Kristen Jensen

Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center Clinical Translational Core

Core whose services include biospecimen collection and storage, development of lung imaging outcomes, imaging training, and biostatical analysis.

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SciCrunch
10 years ago - submitted by Kristen Jensen

Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center Michael Hooker Microscopy Core Facility

Core that provides advanced digital light microscopy, image processing and analysis resources for users from the UNC Chapel Hill campus. It also offers instrumentation and instruction to enable users to acquire, process and analyze images from a wide variety of sample types.

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SciCrunch
10 years ago - submitted by Kristen Jensen

Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center Mouse Models Core

Core that provides support and expertise for mouse colony maintenance, breeding strategies, mouse lung phenotyping protocols, and submission of live-animal applications to maintain compliance with IACUC guidelines.

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SciCrunch
10 years ago - submitted by Kristen Jensen

Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center

Research team dedicated to finding a cure for cystic fibrosis lung disease. This team utilizes ion transport physiology, transgenic and gene-targeted mouse models, Phase I clinical trials, and more to research this cause.

Resource
SciCrunch
10 years ago - submitted by Kristen Jensen

Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center Pre-Clinical Core

Core whose objectives include evaluation of pre-clinical drug candidates in vitro, pre-clinical drug candidates ex vivo, and pre-clinical drug candidates in vivo.

Resource
SciCrunch
10 years ago - submitted by Kristen Jensen

Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center Functional Analysis Core

Core that analyzes ion channel properties and correction efficiency of human bronchial epithelial (HBE) cells from harvested CF lungs to provide a full characterization report to investigators, measures ion transport function of CFTR and ENaC in HBE and human nasal epithelial (HNE) cultures by bioelectric and organoid assays to asses efficacy of candidate therapies, evaluates CFTR expression and processing by biochemical analyses to assess efficacy of CFTR modulation strategies, and validates the suitability of reagents, supplies, and techniques for optimizing HBE and HNE cell integrity.

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SciCrunch
10 years ago - submitted by Kristen Jensen

Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center Histology Core

Core that provides light microscopy services like prosection, tissue fixation, processing, embedding, sectioning, staining and cover slipping of paraffin, frozen and soft plastic tissue sections, as well as specialized and routine fixation, tissues processing, ultramicrotomy, staining, photomicrograph production, and analysis.

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SciCrunch
10 years ago - submitted by Kristen Jensen

Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center Molecular Biology Core

Core facility that provides expertise, equipment, training, and reagents to serve the molecular biology needs for cystic fibrosis research.

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SciCrunch
10 years ago - submitted by Kristen Jensen

Cystic Fibrosis Research and Translation Centers

Research centers that provide support for basic, preclinical, and clinical research efforts to advance scientific knowledge and new therapies for cystic fibrosis.

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SciCrunch
10 years ago - submitted by Kristen Jensen

Nuance Multispectral Imaging Systems

Microscope that can visualize multiple nuclear, cytoplasmic and membrane markers in the same tissue section and with intact morphology. Its features include detection and measurement of weakly expressed and overlapping biomarkers in fixed tissue sections, autofluorescence removal technology, and the ability to work with both fluorescence and brightfield samples.

Resource
RRID-Legacy
10 years ago - by Anonymous

PsychoFit

Software that fits s-shaped psychometric functions to psychophysical data using a maximum-likelihood technique. The psychometric functions available are logistic, Weibull, Gaussian integral, cumulative Poisson and step. PsychoFit produces, among other things, files with graphic information suitable for importing in a graphic program for plotting., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025.

Resource
RRID-Legacy
10 years ago - by Anonymous

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