Curator Dashboard

Center that is organized to address cross-cutting themes that represent gaps in understanding the relationship between nutrition and health, and the pathogenesis of obesity and its associated metabolic diseases.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core that facilitates and fosters research on mechanisms regulating white, brite or beige and brown adipose tissue mass, distribution, nutrient signaling and depot-specific metabolic and endocrine functions in health and disease.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Research center that aims to understand the causal factors underlying nutrition and obesity-related health problems and the generation and evaluation of evidence on their consequences, prevention, and alleviation.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core facility which provides support to cystic fibrosis investigators in gene transfer technologies through consultation, development of novel vectors, collaborative testing of vectors for function and purity, and routine vector preparations.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core facility which provides a range of technologies for morphologically based studies and technically more complex support in the detection of transgenes and transgene products using techniques of in situ hybridization and immunohistochemistry.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core facility which aims to provide cystic fibrosis researchers with a biobank of archived biosamples collected during routine clinical visits and research-related visits. Biospecimens include normal and CF specimens including DNA, bronchoalveolar lavage fluid, whole blood, plasma, feces, urine, and bacterial isolates. It also aims to facilitate patient recruitment and enrollment in clinical trials.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core that allows investigators to efficiently and cost effectively define the phenotypes of small rodents in ways that are relevant to the study of obesity, nutrition, and metabolism. Its services range from whole animal measurements of body composition and energy utilization, to ex vivo measurements of substrate fluxes, to histological analyses of adipose tissue.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core that provides support to investigators who use animal models to study the pathogenesis of cystic fibrosis and who develop gene and other molecular therapies for cystic fibrosis. Specifically, it provides centralized production, care, breeding, genotyping, and quality control of cystic fibrosis mouse and ferret models used by investigators in the Center.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Research center which provides access to core facilities and services to aid gene therapy researchers.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core facility which provides comprehensive necropsy, histology, and pathology services for animal models in order to facilitate translational research in animal models of cystic fibrosis. It also houses instrumentation which allows for high-throughput optimization of immunostaining protocols and has access to morphologic equipment that allow for the scanning of large tissue areas and morphometric quantification of histologic endpoints.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core that provides centralized access to non-cystic fibrosis and cystic fibrosis tissue specimens and airway cells used for model systems to assess gene transfer to the airway and pathophysiology in cystic fibrosis.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core facility which provides a variety of assay services to evaluate cell-mediated and humoral responses to in animal models of gene therapies.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core that manages and oversees the UW CFRTC and its cores and pilot and feasibility programs.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core that provides Ussing chamber capabilities and expertise for testing vectoral anion transport in polarized airway epithelial monolayers, and florescent dye-based methods for evaluating CFTR activity in cells grown on coverslips. The core also performs immunolocalization for proteins relevant to cystic fibrosis pathogenesis.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Research center whose focus is on developing effective gene vectors derived from recombinant viruses. Much of their research is in the development of new adeno-associated virus (AAV) vectors, although some of their research involves both adenoviruses and lentiviruses.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core whose objective is to obtain information on relevant parameters of the host response that is unique to cystic fibrosis using a variety of techniques, including in vivo and in vitro imaging, immunohistochemistry, imaging and image analysis, cells and bacteria in tissues, and quantification of chemokines, cytokines, and other factors with ELISA.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core provides genomics-based tools, data management and analysis tools, and creates platforms that integrate data from the Clinical and Immunology Cores for human samples and bacterial isolates. Services include consultation and experimental design assistance for using new-generation sequencing technology, data analysis, bioinformatic support, data access and storage, high throughput and new-generation whole-genome sequencing, and RNA-seq analysis of transcriptomes.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core facility which provides tools, reagents, and training for microbiological researchers investigating cystic fibrosis. They specifically provide resources for research in anti-bacterial therapies,

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core that aims to provide preclinical support for novel therapeutics, work with other biomedical cores to enhance and support bacterial and human specimen repositories, and support developmental research and training.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Research center that aims to provide resources and expertise to expedite development of potential new therapeutic approaches to correct dysfunctional CFTR and its secondary consequences, enhance understanding of evolving bacterial ecosystems and resultant host response in CF gastrointestinal and respiratory tracts, and how these interactions impact health. It also aims to develop improved assays, new drug screening assays, biomarkers and improved clinical outcome measures, as well as to better understand the metabolic and inflammatory consequences of CFTR dysfunction.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen