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A global network group resource which provides crowdsourcing services for “innovation solutions.” InnoCentive utilizes an innovation framework, called Challenge Drive Innovation, which is based on leveraging open innovation and crowdsourcing. Software tools are available for idea management, innovation management, and external crowdsourcing programs and competitions.
A gene-based score intended to help in the interpretation of human sequence data. The score is designed to rank genes in terms of whether they have more or less common functional genetic variation relative to the genome wide expectation given the amount of apparently neutral variation the gene has. A gene with a positive score has more common functional variation, and a gene with a negative score has less and is referred to as intolerant.
A software application which tracks EPBs. EPBscore tool uses maximal intensity for the following reasons: 1) the integrated intensity is affected by the sampling density and it is not clear how large an area one should integrate over. This is often determined by ad- hoc criteria with no theoretical justification. 2) The integrated intensity is susceptible to movement artifacts. 3) As shown in (Grillo et al. 2013), the maximal intensity scales over the whole range of EPB intensities is considered. Importantly, the tool successfully minimizes human input by automating the EPB scoring and measurement steps., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025.
A biomaterial supply resource which provides human and animal biological matrices and services. Human biomaterials and tools include hepatocytes, clinical samples, normal samples, subcellular fractions, immunology products, renal cells, cell cultures, and diagnostic tools. Animal biomaterials include hepatocytes, blood, fluid, and tissue samples, subcellular fractions, and cell cultures. Custom cells and clinical samples are available for purchase, as are hepatocyte and renal media.
Commercial biomaterial supply resource which provides an extensive biorepository as well as an exclusive human tissue-based research service. The biobank contains defined and categorized clinical samples of tissues, blood, serum, bone marrow, and tissue microarrays. ProteoGenex collects biomaterials for a variety fields, including oncology, neurology, and immunology. Normal tissues are collected, as well. All samples are supported by pathology information and patient clinical history documentation. ProteoGenex also offers custom collection design.
A biomaterial supply resource which archives and disseminates brain tissue for the study of normal brain aging and brain disorders. Researchers must create an account in order to browse the database of available tissue. Samples are distributed to researchers in such a way that the identity and personal information of donors is protected.
A biomaterial supply resource which collects, stores, and disseminates biomaterial and clinical data relating to neurological disorders, psychiatric disorders, cardiology pathologies, and pneumology pathologies. NeuroBioTec has 18 collections with a total of 100,000 samples of serum, plasma, cerebrospinal fluid, PBMC, urine, tissue, DNA and RNA. Some samples can be made available to external researchers under certain conditions.
A biomaterial supply resource which collects, stores, and disseminates diseased and healthy brain tissue. The Netherlands Brain Bank currently contains more than 3600 samples, and each sample includes a neuropathological report and donor medical history. The samples can additionally be matched with ante-mortem parameters and post-mortem parameters upon request. Sample types include cortex, spinal cord, cerebrospinal fluid, plasma, and DNA, among others. Database mining is available with a financial contribution.
A biomaterial supply resource which provides high quality, clinically and neuropathologically well-characterised human brain and spinal cord tissue. The Brain Bank focuses on neurodegenerative diseases such as Alzheimer’s Disease (AD), Frontotemperal dementias (FTD) and Motor Neurone Disease (MND). However, it also contains tissues for the study of HIV, Autism and Schizophrenia, and movement disorders.
A biomaterial supply resource which supplies brain tissue for researchers studying dementia and other neurodegenerative diseases. The Maritime Brain Tissue Bank archives tissues related to Alzheimer's Disease, mixed dementias, Lewy Body Disease, and Huntington's Disease, among others.
A biomaterial resource which stores and distributes dissected human brain samples and topographically oriented tissue blocks. Most brains were removed from the skull and frozen within 2-6 hours after death. The microdissection of 260 different brain nuclei is performed on frozen brains and the samples are kept in -70ºC. Materials must be studied in the course of an approved research project, which has scientific aims and is devoid of any commercial profit for the researches involved and for their respective institutions.
A collaborative project between the Broad Institute and the Novartis Institutes for Biomedical Research and its Genomics Institute of the Novartis Research Foundation, with the goal of conducting a detailed genetic and pharmacologic characterization of a large panel of human cancer models. The CCLE also works to develop integrated computational analyses that link distinct pharmacologic vulnerabilities to genomic patterns and to translate cell line integrative genomics into cancer patient stratification. The CCLE provides public access to genomic data, analysis and visualization for about 1000 cell lines.
A software registry which offers links to various free statistical software programs for stand-alone computing. The software programs are split into different categories: General Packages, Subset Packages, Curve Fitting and Modeling, Biostatistics and Epidemiology, Surveys, Testing and Measurement, Excel Spreadsheets and Add-ins, Programming Languages and Subroutine Libraries, Scripts and Macros, Miscellaneous, and Other Collections.
An on-going atlas project of the Virtual Insect Brain Project with the goal of reconstructing and standardizing Gal4 expression patterns in Drosophila brains. Neurofly will be a web-based tool that will enable the online comparison of mutations and Gal4 expression patterns in the Drosophila brain. To this end, a database of reconstructed and standardized Gal4 expression patterns - on the basis of the existing Drosophila StandardBrain - was developed along with tools for 3D image data set processing. Users will be able to evaluate the expression patterns intersections of various Gal4 driver lines and/or mutations.
A neuronal simulation software application used to study spinal cord neuronal network systems for muscle control. Users can investigate phenomena at several levels of organization, such as the neuronal membrane level or the whole muscle behavior level. ReMoto can be used to interpret results, validate experimental protocols, and teach neurophysiology.
Software application which computes cortical three-dimensional distribution of current density of the brain based on the scalp-recorded electric potential distribution. The exact low resolution brain electromagnetic tomography method has the property of exact localization to test point sources, yielding images of current density with exact localization, albeit with low spatial resolution. eLORETA has no localization bias even in the presence of structured noise. Deep structures, such as the anterior cingulate cortex and mesial temporal lobes, can be correctly localized with these methods.
A software application which computes images of electric neuronal activity from EEG and MEG. Standard Low Resolution Brain Electromagnetic Tomography, or sLORETA, localizes “test point sources” exactly (under ideal conditions) when estimating electric neuronal generators. This property can be generalized to any source distribution, based on the principles of linearity and superposition. However, it would be noted that sLORETA has very low spatial resolution.
A set of many statistics calculators, including a confidence interval calculator.
A database which provides a comprehensive and regularly updated collection of genetic association studies performed on multiple sclerosis phenotypes. Eligible publications are identified following systematic searches of scientific literature databases as well as the table of contents of journals in genetics, neurology, and immunology.
A database providing information about compounds under investigation for therapeutic use. There are currently 44 compounds on record with 100 compounds in the process of being uploaded to the database.