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The goal of this follow-up study of mothers who participated in the Hyperglycemia and Adverse Pregnancy Outcomes (HAPO) study is to determine the levels of blood sugar during pregnancy that are linked to increased body fat in the child, as well as to determine the chances of a mother developing diabetes 8-12 years after the pregnancy. The original study examined 23,316 mother-child pairs, and researchers determined that the hyperglycemia of a mother was linked to newborn birth weight and body fat. HAPO-FUS will enroll 7,000 or the original HAPO mother-child pairs for one follow-up visit to assess body composition, blucose metabolism, medical history, and other metabolic parameters.

• Resource
• dkNET
• 11 years ago - submitted by Ko-Wei Lin

A consortium whose overall goal is to identify effective behavioral and lifestyle interventions that will improve weight, glycemic control and other pregnancy-related outcomes in obese and overweight pregnant women, and determine whether these interventions reduce obesity and metabolic abnormalities in their children. The study/consortium is comprised of seven clinical centers, with each clinical center conducting its own trial. Additional information on the consortium and individual trials is located in the Consortium Summaries tab.

• Resource
• dkNET
• 11 years ago - submitted by Ko-Wei Lin

A study of how children newly diagnosed with ulcerative colitis (UC) respond to mesalamine and prednisone (corticosteroid), the standard initial therapies used to treat this disorder. Over a period of 5 years PROTECT will prospectively study the course of 430 children newly diagnosed with UC who are treated with standardized care. Biospecimens (blood, stool, colonic biopsy tissue) will be obtained and used to better understand the effects of genetics, mechanisms of inflammation, Vitamin D, and the bacteria contained in the stool (microbiome) on clinical outcomes.

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• dkNET
• 11 years ago - submitted by Ko-Wei Lin

A prospective, observational follow-up study of at least 8000 participants who were treated and followed in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Trial. Treatment in ACCORD ended in 2009 and ACCORDION is designed to further elucidate the long-term effects of the ACCORD treatment strategies and provide additional data on the relationships among various cardiovascular and diabetic risk factors.

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• dkNET
• 11 years ago - submitted by Ko-Wei Lin

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on June 29,2023. Registry listing NIDDK resources, such as reagents, data, and protocols. They are derived from publicly available information provided by NIDDK-funded investigators, projects, and publications.

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• dkNET
• 11 years ago - submitted by Ko-Wei Lin

A registry of cytokines, chemokines, and receptors generated for the purpose of collecting, integrating, and mapping between entity names and synonyms from several resources. These resources include MeSH, the Protein Ontology, EntrezGene, HGNC, MGI, UniProt and others.

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• SciCrunch
• 11 years ago - submitted by Anita Bandrowski

A kit which enables isolation and enrichment for intact lysosomes from crude cell and tissue extracts. The kit provides sufficient reagents for preparing 25 extracts and uses OptiPrep Cell Separation Media for the density-based separation of lysosomes from contaminating cell structures.

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• SciCrunch
• 11 years ago - submitted by Michael Marshall

A conjugated form of isolectin B4 for fluorescence identification of non-peptidergic nociceptors in mouse dorsal root ganglia and spinal cord.

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• SciCrunch
• 11 years ago - submitted by Daniel DuBreuil

An application which provides an environment to explore and organize scholarly data. Rexplore leverages solutions in large-scale data mining, semantic technologies and visual analytics, which allows users to detect and follow research trends, identify and map relationships between authors, perform expert searches, and analyze research performance.

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• SciCrunch
• 11 years ago - by Anonymous

Software tool for automatically scheduling events for rapid-presentation event-related (RPER) fMRI experiments (the schedule is the order and timing of events). Events in RPER are presented closely enough in time that their hemodynamic responses will overlap. This requires that the onset times of the events be jittered in order to remove the overlap from the estimate of the hemodynamic response. RPER is highly resistant to habituation, expectation, and set because the subject does not know when the next stimulus will appear or which stimulus type it will be.

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• SciCrunch
• 11 years ago - submitted by Maryann Martone

A cross-platform integrated development environment (IDE) for Free Pascal. It contains a class library (LCL) that supports rapid application development for native code on numerous platforms, processor architectures and operating systems.

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• SciCrunch
• 11 years ago - submitted by Johannes W. Dietrich

Specific, sensitive, precise and accurate CLIA for 3,5-T2 detection in human serum.

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• SciCrunch
• 11 years ago - submitted by Johannes W. Dietrich

Free Pascal is a 32, 64 and 16 bit professional Object Pascal compiler targeting multiple processor architectures and operating systems. Documentation, including guides and manuals, are available on the website.

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• SciCrunch
• 11 years ago - submitted by Johannes W. Dietrich

An ontology distributed in OWL format which contains comprehensive terms describing ion channel electrophysiology. Terms from related ontologies, such as Cell Physiology Ontology (CPO), Cardiac Electrophysiology Ontology (CEPO), and Unit Ontology, were integrated into ICEPO.

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• SciCrunch
• 11 years ago - submitted by Anita Bandrowski

A cross-platform class library for development of high-performance life science computer simulations. It supports modelling for biomedical cybernetics and systems biology with Object Pascal. It contains a set of Pascal units for rapid programming of high-performance computer simulations called the Brick collection.

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• SciCrunch
• 11 years ago - submitted by Johannes W. Dietrich

A commercial geospatial tool typically used for orthorectification and mosaicking of aerial and satellite imagery; however, it can also be used for biomedical imaging and modeling purposes. The developer software contains image processing tools and functions to edit images and design custom applications.

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• SciCrunch
• 11 years ago - submitted by Anita Bandrowski

A web application immune repertoire management, analysis, and archiving. Users can collaborate and share data either privately or publicly. Users can perform a variety of tasks, such as create and share projects with other users, conduct pre-processing tasks on single end reads, run IgBlast, and obtain basic repertoire characterization results for B cell receptor and T cell receptor repertoires.

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• SciCrunch
• 11 years ago - submitted by Anita Bandrowski

A comprehensive resource specializing in the use of the amphibian Xenopus laevis (the African clawed frog) for biomedical and immunological research. Several genetically-defined inbred strains and clones are available for study. The facility also maintains and develops research tools such as transgenic animals, monoclonal antibodies, cell lines, DNA libraries, and molecular probes. XLRR includes a satellite facility devoted to study infectious diseases caused by iridovirus. Technical assistance, education, and training are also provided.

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• SciCrunch
• 11 years ago - by Anonymous

A package for statistical relative quantification of proteins and peptides in global, targeted, and data-independent proteomics. It handles shotgun, label-free, and label-based Selected Reaction Monitoring, as well as SWATH/DIA (Data Independent Acquisition) experiments. MSStats provide functionality for data processing and visualization, model-based statistical analysis, and model-based sample size calculations.

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• SciCrunch
• 11 years ago - submitted by James Go

Software tool to deliver estimated structure parameters of endocrine feedback control systems in vivo from serum or plasma hormone levels. Used for evaluation of thyroid function. Allows for calculating thyroid maximum secretory capacity (GT or SPINA-GT) and sum activity of peripheral 5'-deiodinases (GD or SPINA-GD) from levels of TSH, (F)T4 and (F)T3 that have been determined once only (SPINA Thyr). Binaries are available for Mac OS, Mac OS X, Palm OS, Garnet OS and Windows. For other operating systems, including Linux, Solaris and BSD, SPINA Thyr is available as sourcecode. Building from source requires THINK Pascal (for Mac OS Classic), winsoft PocketStudio (for Palm OS / Garnet OS) or Lazarus/Free Pascal (for Mac OS X, Windows, Linux, BSD and Solaris). Special version of calculation engine is available for modern S implementation, e.g. R.

• Resource
• SciCrunch
• 11 years ago - submitted by Johannes W. Dietrich