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Core has built technology toolbox with access to and application of novel and existing methods in multitude of genomics technologies. These capabilities span bulk, single-cell, spatial, and in situ genomic sequencing methods, all of which are leveraged to generate complementary cross-platform, orthogonally validated datasets to foster novel discovery and advance clinical applicability using human cohorts and model systems
Core provides team of experts in the characterization of immune profiles and treatment responses across a diverse range of diseases, such as cancer, autoimmunity, allergy, and neuro-immune disorders. Offers equipment in the field for research at Genomic, cellular and proteomic analysis. Develops assays to balance innovation with protocols and operating procedures to ensure data quality and reproducibility.
Facility for conducting preclinical and clinical brain imaging research in the field of mental health. Provides platform to analyze brain imaging data from functional and structural neuroimaging techniques.
Core Facility at the Icahn Genomics Institute (IGI) offers custom-made lipid nanoparticles and RNA technology to develop new therapeutics and nanomedicines.
Software tool to convert FastA and Eggnog-mapper annotation files to GenBank files containing GO terms and EC number annotations, suitable for metabolic network reconstruction using Pathway Tools. Used for creation of genbank files from Eggnog-mapper annotation outputs.
Software pipeline as open-source, cloud-optimized workflow for processing spatial transcriptomics data. It supports data derived from spatially barcoded sequencing technologies, including Slide-tags-based single-molecule profiling. The pipeline processes raw sequencing data into spatially resolved gene expression matrices, ensuring accurate alignment, spatial positioning, and quantification.
Core facility offers researchers access to histological services, tissue visualization, slide scanning, digital image analysis, and next-generation tissue microarrays. Our team processes more than 800 projects per year related to patient tissue, patient-related data, clinical studies, and animal models.
Provides access to collection of human postmortem brain tissues, including fresh, frozen, and formalin-fixed paraffin-embedded (FFPE) specimens, along with detailed clinical histories and neuropathological assessments. Available histology services include processing and embedding, slide sectioning for FFPE and cryosections, immunohistochemistry (IHC), immunofluorescence (IF), and advanced RNA assays such as RNAscope, BaseScope, and miRscope. High-resolution digital slide imaging is performed using the GT450 scanner. CoRE scientists also collaborate with investigators and trainees to support project development, method optimization and troubleshooting, data analysis.
Software package contains tools to use the BICAN Knowledgebase Data Models.
Software tool aimed at data modelers, curators, wrangers, and creators of standards and datamodels. It is aimed at people who prefer to develop these standards using spreadsheet tools over more developer-centric tooling. Human-friendly spreadsheets with machine-actionable models.
Software successor to the Reconstruct annotation tool. PyReconstruct runs on all major operating systems, breaks through legacy RAM limitations, features intuitive and collaborative curation system, and employs flexible and dynamic approach to image registration. Used to analyze, display, and publish experimental or connectomics data. Suited for generating ground truth to implement in automated segmentation, outcomes of which can be returned to PyReconstruct for proofreading and quality control.
Software R package for deconvolving tissue heterogeneity using convex analysis of mixture models.
Double-beam UV-Vis spectrophotometer used for precision measurements in various scientific and industrial applications, such as quality control, environmental monitoring, and biochemical analysis. Its flashing xenon lamp provides a high-intensity, broadband light source for fast, reliable measurements across a wide wavelength range, and its double-beam design ensures accuracy by measuring both the sample and a reference simultaneously.
Software R package for visualizing genomics data. Provides a user-friendly, flexible and comprehensive suite of tools for visualizing complex genomic data in three categories (small variants, copy number alterations and data quality) for multiple species of interest.
805 Series Quenching Dilatometers are the benchmark instruments for scientists and engineers interested in determining dimensional changes and phase transformations of steel alloys. Extremely flexible and configurable, designed to accommodate a wide range of add-on modules enabling it to be tailored to specific user requirements. Quenching, compression, tension, alpha and sub-zero alpha modes all provide highly accurate dimensional change measurements under different conditions and environments.Used for determination of critical parameters in steel manufacturing and heat treatment processes.
Core supports all processing of metal related activity and houses equipment in the areas of thermomechanical processing, additive manufacturing, mechanical testing (including testing under a variety of environments), thermomechanical simulation/testing and heat treatment.
Public research university in Cookeville, Tennessee. It was formerly known as Tennessee Polytechnic Institute, and before that as University of Dixie, the name under which it was founded as a private institution.
Core empowers students, faculty, and staff across all disciplines by providing the tools, training, and equipment for advanced computing for more robust, reproducible research with reduced time to results. Manages the campus cluster, and also facilitate access to larger federally-funded clusters at zero cost. Provided data transfer and network performance monitoring services enable researchers and collaborators to move data quickly.
Web tool, developed by the U.S. National Cancer Institute (NCI), performs statistical modeling of cancer incidence or mortality data using age-period-cohort analysis. It allows users to examine and interpret temporal trends while disentangling the effects of age, calendar period, and birth cohort. The tool supports data import, graphical output, and model fit assessment via interactive web interface.
Cancer Incidence in Five Continents (CI5) is a collaboration between the International Agency for Research on Cancer (IARC) and the International Association of Cancer Registries (IACR) that produces a benchmark series of data on cancer incidence worldwide. This multi-volume publication, released approximately every five years, compiles standardized data on newly diagnosed cancer cases from population-based cancer registries across the globe. The data provide a unique source of comparable information on the global burden and distribution of cancer and help inform cancer control programs.