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Software single-cell TE processing pipeline to report the expression of TEs in single cells in a range of biological contexts. Used for quantifying transposable element (TEs) expression from single-cell sequencing data.
Core offers transmission electron microscopy, scanning electron microscopy and serial block-face electron microscopy services. Provides scientific and technical support to investigators pursuing ultrastructural studies.Facility is expertly staffed and equipped to provide services including Project consultation, Specimen preparation,Imaging and data analysis.Investigator training for equipment operation and data analysis also is available.
Core provides spaces and equipment to support fabrication projects ranging from micro sized to complex product development. We offer mentorship, apprenticeship, training and full service expertise in computer aided design and reverse engineering, rapid prototyping, electronics, machining, CNC computer aided programming, scientific glassblowing, welding, woodworking and more.
Core provides biorepositories and biospecimen processing and storage. Provided services include Support for setting up study-specific infrastructures needed for biospecimen collection, processing and routing; Accessioning and processing;Nucleic acid extraction, plating and peripheral blood mononuclear cell isolation and cryopreservation;Bodily fluid processing for microbiomes, including DNA extraction;Storage, shipping and sample collection kit assembly.Core is fully automated and highly scalable. Automation includes:Sample sorters,Robotic liquid handlers for blood processing and aliquoting, including plasma, serum, urine, buffy coat and red blood cells; Nucleic acid extractions; DNA plating, and sample storage including conventional freezers with a temperature of minus 112 degrees Fahrenheit (minus 80 degrees Celsius), liquid nitrogen freezers and robotically controlled high-capacity freezers that are maintained at minus 112 degrees Fahrenheit (minus 80 degrees Celsius).
Software low coverage whole genome sequencing imputation method that scales sublinearly in both the number of samples and markers, achieving efficient whole-genome imputation from the UK Biobank reference panel while retaining high accuracy for ancient and modern genomes, particularly at rare variants and for very low-coverage samples. Used for low coverage calling of genotypes.
Web multimodal data labeling and annotation platform that supports a wide range of data types, including images, text, audio, documents, and AI model outputs. It provides configurable annotation workflows and standardized output formats for machine learning, computer vision, NLP, LLM evaluation, and RLHF.
Software tool for the analysis of muscle activity during sleep.
JavaScript/TypeScript software package and framework designed for structuring, validating, managing, and querying taxonomic and biodiversity data. Based on object-oriented programming principles, TTS employs strongly typed classes and hierarchical, JSON-compatible data structures to represent taxa, morphological characters, biological attributes, and associated bibliographic sources. It supports modular data modeling, validation, documentation, and collaborative version control, promoting consistency, traceability, and reusability of scientific information. Initially developed for plant systematics, particularly the genus Mimosa (Fabaceae), TTS provides a flexible approach to organizing complex biological datasets across taxonomic and biodiversity research applications.
Core provides access to custom production of novel transgenic, gene knockout, and gene knockin rat and mouse models, management of rat model breeding colonies, assisting research staff with procedures involving production and maintenance of transgenic mouse and rat strains. Provides both sperm and embryo cryopreservation/recovery, IVF, ICSI, pronuclear microinjection. Provides consultation involving colony breeding issues.
Core provides support including management of and access to instrumentation cores and other equipment, clinical research coordination, writer, editor, and biostatistician services.
High-resolution, open-volume microfluidic 3D single-cell bioprinter. Allows researchers to 3D-print living cells down to the single-cell level with high precision (over 95% cell viability). It does not use traditional bioinks, gels, or scaffolds, instead letting cells adhere directly in native culture media.
Web-based research resource for finding and following biomedical literature on aging and age-related disease. It connects paper records and source-linked research summaries with clinical trials and topic pages. The platform provides literature search, followed topics, RSS feeds, a data API and a hosted Model Context Protocol (MCP) server for research tools. Public research pages can be read without an account; personal and advanced features require an account or subscription. Maintained by Paperfoot AI Pte. Ltd.
Web platform for publishing, reading and running computational research as marimo notebooks. Notebooks are plain Python files with version history. Public projects have stable URLs and author citations, and readers can fork them into their own namespaces. User and organisation profiles group projects; subject browsing helps researchers find related work. The platform is intended for researchers, readers and laboratories across scientific fields.
Software gene model extension tool for enhanced single-cell RNA-seq analysis. Gene extension for improved scRNA-seq data counting.
Software command-line tool for CNV (Copy Number Variation) analysis in high-resolution spatial transcriptomics. It is the upgraded version of stmut, built to handle high-resolution spatial transcriptomics data (VisiumHD, Atera).
Web tool that looks up Research Resource Identifiers (RRIDs) to verify and connect scientific tools to their official database records. It takes a unique RRID (such as for a cell line, antibody, model organism, core facility or software tool) and points you to the official database record or registry entry.
Software marker-based qualitative quality control framework for high-resolution spatial transcriptomics data. Provides a solution for low-quality ST data which fails standard analysis workflow, and a rapid qualitative QC step before any in-depth analysis. Marker gene based qualitative QC pipeline for spatial transcriptomics data.
Porvides codes which are a classification scheme allowing for flexible, census tract delineation of rural and urban areas throughout the United States and its territories. RUCA codes were designed to address a major limitation associated with county-based classifications; they are often too large to accurately delineate boundaries between rural and urban areas. The more geographically-detailed information provided by RUCA codes can be used to improve rural research and policy—such as addressing concerns that remote, rural communities in large metropolitan counties are not eligible for some rural assistance programs. The RUCA codes consist of two levels. The primary RUCA codes establish urban cores and the census tracts that are the most economically integrated with those cores through commuting. The secondary RUCA codes indicate whether a census tract has a strong secondary connection (through commuting) to an even larger urban core. This two-level structure provides flexibility in combining levels to meet varying definitional needs and preferences. The RUCA codes were created using census tract data and were subsequently adapted to ZIP codes.
Portal provides classification system used to measure the geographic isolation and low population density of sub-county locations (such as ZIP codes and census tracts) across the United States. Codes classify the remoteness of U.S. census tracts and ZIP Codes. Locations are characterized as "frontier and remote" by a combination of low population and geographic isolation from cities and towns. There are four nested FAR code levels that capture the varying degrees of remoteness experienced throughout the country. This allows users to choose the definition of frontier and remote that best suits their specific needs.
Software R package implements a wmwAUC test of H0: AUC = 1/2 for continuous, discrete, or mixed random variables, based on the Wilcoxon-Mann-Whitney (WMW) statistic. The classic WMW test is calibrated under H0: {(F, G): F = G} which does not match the set {(F, G): AUC = 1/2}, implied by the test statistic, and consequently leads to erroneous inferences. wmwAUC is calibrated under the correct null and implements two finite-sample corrected p-value methods: an Exact Unbiased (EU) method and a Bias-Corrected (BC) method, both valid for any tie pattern.