Curator Dashboard

Core focused on systems genetics approach to understanding diseases, development, aging, and fertility in mouse. Projects range from development of new community resources, such as Collaborative Cross, to development of tools and assays for measuring genetic diversity and discerning genomic structure. Collaborative Cross is reference population for mapping multigenic traits that would be free of population structure and it is new panel of recombinant inbred lines generated by randomizing genetic diversity of existing inbred mouse resources.

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• SciCrunch
• 7 years ago - submitted by Ethan Badger

Abcam Cat# ab138222

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• SciCrunch
• 7 years ago - submitted by Yingying Jiang

You can use SMART in two different modes: normal or genomic.The main difference is in the underlying protein database used. In Normal SMART, the database contains Swiss-Prot, SP-TrEMBL and stable Ensembl proteomes. In Genomic SMART, only the proteomes of completely sequenced genomes are used; Ensembl for metazoans and Swiss-Prot for the rest.

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• SciCrunch
• 7 years ago - submitted by Jie Yang

ProDom is a comprehensive set of protein domain families automatically generated from the UniProt Knowledge Database

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• SciCrunch
• 7 years ago - submitted by Jie Yang

PRINTS is a compendium of protein fingerprints.

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• SciCrunch
• 7 years ago - submitted by Jie Yang

Test to see if user receives RRID immediately at webpage after submission

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• dkNET
• 7 years ago - submitted by Ko-Wei Lin

TGF-beta 1 (transforming growth factor beta 1) is one of three closely related mammalian members of the large TGF-beta superfamily that share a characteristic cystine knot structure (1‑7). TGF-beta 1, -2 and -3 are highly pleiotropic cytokines that are proposed to act as cellular switches that regulate processes such as immune function, proliferation and epithelial-mesenchymal transition (1‑4). Each TGF-beta isoform has some non‑redundant functions; for TGF-beta 1, mice with targeted deletion show defects in hematopoiesis and endothelial differentiation, and die of overwhelming inflammation (2). Human TGF‑ beta 1 cDNA encodes a 390 amino acid (aa) precursor that contains a 29 aa signal peptide and a 361 aa proprotein (8). A furin‑like convertase processes the proprotein to generate an N‑terminal 249 aa latency‑associated peptide (LAP) and a C‑terminal 112 aa mature TGF‑ beta 1 (8, 9). Disulfide‑linked homodimers of LAP and TGF‑ beta 1 remain non‑covalently associated after secretion, forming the small latent TGF‑ beta 1 complex (8‑10). Covalent linkage of LAP to one of three latent TGF‑ beta binding proteins (LTBPs) creates a large latent complex that may interact with the extracellular matrix (9, 10). TGF‑ beta is activated from latency by pathways that include actions of the protease plasmin, matrix metalloproteases, thrombospondin 1 and a subset of integrins (10). Mature human TGF‑ beta 1 shares 100% aa identity with pig, dog and cow TGF‑ beta 1, and 99% aa identity with mouse, rat and horse TGF‑ beta 1. It demonstrates cross‑species activity (1). TGF‑ beta 1 signaling begins with high‑affinity binding to a type II ser/thr kinase receptor termed TGF‑ beta RII. This receptor then phosphorylates and activates a second ser/thr kinase receptor, TGF‑ beta RI (also called activin receptor‑like kinase (ALK) ‑5), or alternatively, ALK‑1. This complex phosphorylates and activates Smad proteins that regulate transcription (3, 11, 12). Contributions of the accessory receptors betaglycan (also known as TGF‑ beta RIII) and endoglin, or use of Smad‑independent signaling pathways, allow for disparate actions observed in response to TGF‑ beta in different contexts (11).

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• SciCrunch
• 7 years ago - submitted by Jialei Duan

anti-EGF Receptor (3F12) Mouse mAb is antibody from Zen bioscience used only in research.

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• SciCrunch
• 7 years ago - submitted by Wang Zheng

anti-Oct4 (3F5) Mouse mAb is antibody from Zen bioscience in China for research use only.

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• SciCrunch
• 7 years ago - submitted by Wang Zheng

Provide tools for research study in genetics, biochemistry, proteomics, and genomics.

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• RRID-Legacy
• 7 years ago - submitted by Ethan Badger

Core provides support, assistance and training in wide range of bioinformatics topics. Maintains high-performance computing resource offering many bioinformatics applications, substantial processing power and secure storage. Provides support for desktop computing and poster printing. Services include Data Analysis, Software Support (access to proprietary bioinformatics resources Ingenuity Pathway Analysis and GeneGO MetaCore, Training sessions covering various bioinformatics topics, Linux compute cluster,data storage.

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• RRID-Legacy
• 7 years ago - submitted by Ethan Badger

The CRG is an international biomedical research institute of excellence whose mission is to discover and advance knowledge for the benefit of society, public health and economic prosperity. Goals To be a world leading centre in biomedical science, by providing our scientists with a stimulating environment, cutting edge technologies and the freedom to conduct the most innovative research. To communicate and establish a dialogue with society, by educating the public and being receptive to their needs. To provide multi- and inter-disciplinary training for the next generation of scientists as well as supporting science education. To translate new scientific knowledge into benefits for health and value for society.The CRG is a unique centre in Spain, based in an innovative organization research model. Group leaders at the CRG are recruited internationally and receive support from the centre to set up and run their groups. An external Scientific Advisory Board, made up of 15 world leaders in the different areas, evaluates them. The result of evaluations conditions the future of the CRG scientists, no matter whether they have open-ended or time-limited contracts. This ensures the mobility and the renewal of the workforce.The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, created in December 2000. It is a non-profit foundation funded by the Catalan Government through the Departments of Business & Knowledge, the Spanish Ministry of Science, Innovation & Universities, the "la Caixa" Banking Foundation, and includes the participation of Pompeu Fabra University. The mission of the CRG is to discover and advance knowledge for the benefit of society, public health and economic prosperity.

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• SciCrunch
• 7 years ago - submitted by Edyta Vieth

The University of Tartu is a classical university in the city of Tartu, Estonia. It is the national university of Estonia. The University of Tartu is the only classical university in the country and also the biggest and most prestigious university in Estonia.

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• SciCrunch
• 7 years ago - submitted by Edyta Vieth

InterProScan 5: genome-scale protein function classification

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• SciCrunch
• 7 years ago - submitted by Julien Bane

A antibody for Servicebio

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• SciCrunch
• 7 years ago - submitted by shanshan liu

A data platform is designed to ingest, harmonize, aggregate, store, visualize, and disseminate human invasive neurophysiology data from BRAIN Initiative investigations. It provides a seamless interface for researchers uploading data and novel, intuitive ways for users to search and analyze the archive’s contents. In addition to comprehensive search, download, and data upload functionality, as well as streamlined data upload capabilities, DABI includes an interactive data visualization environment and integration with a suite of data-processing tools. DABI accommodates a wide variety of invasive neurophysiology data types, as well as imaging, behavioral and clinical data, in order to create a comprehensive picture of the human brain in health and disease. The infrastructure supporting DABI is comprised of fail-safe, redundant and secure components, more than 7PB of storage capacity and significant compute power.

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• RRID-Legacy
• 7 years ago - submitted by Anita Bandrowski

Phospho-GSK-3alpha/beta (Ser21/9) (37F11) Rabbit mAb (GSK-3α Preferred) preferentially detects endogenous levels of GSK-3α when phosphorylated at Ser21 and also detects GSK-3β when phosphorylated at Ser9. Species Reactivity: Human, Mouse, Rat, Monkey

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• SciCrunch
• 7 years ago - submitted by Chen Sun

target probe for manual ISH - pre-pro-galanin

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• RRID-Legacy
• 7 years ago - submitted by Jonathan levy

Target probe for manual ISH

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• RRID-Legacy
• 7 years ago - submitted by Jonathan levy

miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades.

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• SciCrunch
• 7 years ago - submitted by Julien Bane