Curator Dashboard

Core whose services include anatomic pathology review of human and experimental animal tissues as well as consultation in the best approaches for such analyses, cost-effective and high quality processing and staining of formalin-fixed paraffin-embedded tissues, and making collections of human tissue and imaging technologies available to researchers.

• Resource
• SciCrunch
• 9 years ago - submitted by Isabella Froman

Core that serves as both a central repository for all the samples and data shared by the other cores and a catalyst for interdisciplinary research.

• Resource
• SciCrunch
• 9 years ago - submitted by Isabella Froman

Center whose goal is to investigate signal transduction mechanisms regulating homeostasis and GI disorders. Their approach includes studies on genetics and gene regulation, cellular signaling pathways, receptors and ion channels.

• Resource
• SciCrunch
• 9 years ago - submitted by Isabella Froman

Core that provides services such as a repository for intestinal cell lines, Tissue Engineering Models, experimental materials, and supplies for digestive disease research.

• Resource
• SciCrunch
• 9 years ago - submitted by Isabella Froman

Core that consists of two components: The Enteric Microbiology and The Gnotobiotic Mouse components. The Enteric Microbiology component offers novel screening and advanced technologies for compositional and functional profiling of the resident microbial communities in the gastrointestinal tract. The Gnotobiotic Mouse component enables investigators to study the effects and causal role of specific microorganisms or profiles in vivo.

• Resource
• SciCrunch
• 9 years ago - submitted by Isabella Froman

Core that has oversight of the other four cores of University of Chicago's Digestive Disease Research Core Center and determines the center's overall direction.

• Resource
• SciCrunch
• 9 years ago - submitted by Isabella Froman

Center whose goals include fostering collaboration among basic and clinical investigators, facilitating the use of new technologies in the study of treatment of digestive diseases, and providing education and training for improved treatment and diagnosis.

• Resource
• SciCrunch
• 9 years ago - submitted by Isabella Froman

Core whose purpose is providing primary and immortalized liver cells for experimental use as well as other material such as human liver cells, primary hepatocytes, and immortalized cell lines.

• Resource
• SciCrunch
• 9 years ago - submitted by Isabella Froman

Core that provides services from routine liver histology to complex microscopy and image analysis.

• Resource
• SciCrunch
• 9 years ago - submitted by Isabella Froman

Core that supports study design to sample procurement and storage, to data analysis and presentation, and also focuses on research involving human subjects.

• Resource
• SciCrunch
• 9 years ago - submitted by Isabella Froman

Core facility that uses mass spectrometry coupled to one (1D) and two (2D) dimensional separations by column chromatography or gel electrophoresis to identify, quantify or characterize proteins and their post-translational modifications, that are expressed in well characterized protein fractions from the small intestine, colon, kidney, liver and pancreas. Techniques such as difference gel electrophoresis (DIGE), isobaric tag for relative and absolute quantitation (iTRAQ), tandem mass tags (TMT) and stable isotope labeling of amino acids in cell culture (SILAC) as well as non-labeling methods (MudPIT, multi-dimensional protein identification technology) are available for quantifying relative differences in protein expression and post-translational modifications, such as acetylation, glycosylation, phosphorylation, nitrosation, ubiquitination and novel cleavage sites.

• Resource
• SciCrunch
• 9 years ago - submitted by Isabella Froman

Core that takes advantage of local expertise and resources to enable Center members to analyze cell populations in mouse or human livers. It performs complex analyses on small numbers of human cells, such as those obtained from liver biopsies.

• Resource
• SciCrunch
• 9 years ago - submitted by Isabella Froman

Center whose goal is to integrate bench science with clinical investigation, in support of its vision to understand and cure human liver diseases.

• Resource
• SciCrunch
• 9 years ago - submitted by Isabella Froman

Core facility whose services include establishing Best Practices (BP) and uniform Standard Operating Procedures (SOPs) for the collection, annotation, processing, storage, management, distribution, and ethical use of human specimens, and to provide access to specimens by investigators as well as patient identification, patient recruitment, facilitation of patient trials, translational research and basic research through creation of a patient registry and database.

• Resource
• SciCrunch
• 9 years ago - submitted by Isabella Froman

Core facility that provides state-of-art light microscopy technology to the members of the Hopkins Basic Research Digestive Disease Development Center and to the whole Hopkins scientific community.

• Resource
• SciCrunch
• 9 years ago - submitted by Isabella Froman

Core facility that supports basic, translational, and clinical research in the digestive diseases by providing access to human materials and resources in statistics and study design. Its services promote translation of basic research advances into improved clinical care by offering fresh and archived human specimens, associated clinical metadata, biostatistics and aid in study design.

• Resource
• SciCrunch
• 9 years ago - submitted by Isabella Froman

Core facility that provides Center investigators and their laboratories the tools and advice needed to establish and study mouse (including transgenic and knockout) and human (i.e. GI organoids) physiology of GI disease.

• Resource
• SciCrunch
• 9 years ago - submitted by Isabella Froman

Core facility that supports basic, translational, and clinical research in the digestive diseases by providing access to human materials and resources in statistics and study design. It also aims to to forge connections and support collaboration between HDDC Clinical Associates and Members, support a well-organized infrastructure for acquisition and storage of clinical samples, and provide professional support in biostatistics and study design to HDDC members and Clinical Associates.

• Resource
• SciCrunch
• 9 years ago - submitted by Isabella Froman

Center that aims to advance basic science and translational digestive diseases research at the Johns Hopkins University School of Medicine. Its goal is to improve the health of patients with the broad spectrum of gastrointestinal and hepatic disorders.

• Resource
• SciCrunch
• 9 years ago - submitted by Isabella Froman

Core facility that provides the infrastructure, biologic resources, expertise, and training for cross-disciplinary research on epithelial biology and immune function in mucosal surfaces and solid organs of the GI tract.

• Resource
• SciCrunch
• 9 years ago - submitted by Isabella Froman