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Core facility offers researchers access to histological services, tissue visualization, slide scanning, digital image analysis, and next-generation tissue microarrays. Our team processes more than 800 projects per year related to patient tissue, patient-related data, clinical studies, and animal models.
Provides access to collection of human postmortem brain tissues, including fresh, frozen, and formalin-fixed paraffin-embedded (FFPE) specimens, along with detailed clinical histories and neuropathological assessments. Available histology services include processing and embedding, slide sectioning for FFPE and cryosections, immunohistochemistry (IHC), immunofluorescence (IF), and advanced RNA assays such as RNAscope, BaseScope, and miRscope. High-resolution digital slide imaging is performed using the GT450 scanner. CoRE scientists also collaborate with investigators and trainees to support project development, method optimization and troubleshooting, data analysis.
Software package contains tools to use the BICAN Knowledgebase Data Models.
Software tool aimed at data modelers, curators, wrangers, and creators of standards and datamodels. It is aimed at people who prefer to develop these standards using spreadsheet tools over more developer-centric tooling. Human-friendly spreadsheets with machine-actionable models.
Software successor to the Reconstruct annotation tool. PyReconstruct runs on all major operating systems, breaks through legacy RAM limitations, features intuitive and collaborative curation system, and employs flexible and dynamic approach to image registration. Used to analyze, display, and publish experimental or connectomics data. Suited for generating ground truth to implement in automated segmentation, outcomes of which can be returned to PyReconstruct for proofreading and quality control.
Software R package for deconvolving tissue heterogeneity using convex analysis of mixture models.
Double-beam UV-Vis spectrophotometer used for precision measurements in various scientific and industrial applications, such as quality control, environmental monitoring, and biochemical analysis. Its flashing xenon lamp provides a high-intensity, broadband light source for fast, reliable measurements across a wide wavelength range, and its double-beam design ensures accuracy by measuring both the sample and a reference simultaneously.
Software R package for visualizing genomics data. Provides a user-friendly, flexible and comprehensive suite of tools for visualizing complex genomic data in three categories (small variants, copy number alterations and data quality) for multiple species of interest.
805 Series Quenching Dilatometers are the benchmark instruments for scientists and engineers interested in determining dimensional changes and phase transformations of steel alloys. Extremely flexible and configurable, designed to accommodate a wide range of add-on modules enabling it to be tailored to specific user requirements. Quenching, compression, tension, alpha and sub-zero alpha modes all provide highly accurate dimensional change measurements under different conditions and environments.Used for determination of critical parameters in steel manufacturing and heat treatment processes.
Core supports all processing of metal related activity and houses equipment in the areas of thermomechanical processing, additive manufacturing, mechanical testing (including testing under a variety of environments), thermomechanical simulation/testing and heat treatment.
Public research university in Cookeville, Tennessee. It was formerly known as Tennessee Polytechnic Institute, and before that as University of Dixie, the name under which it was founded as a private institution.
Core empowers students, faculty, and staff across all disciplines by providing the tools, training, and equipment for advanced computing for more robust, reproducible research with reduced time to results. Manages the campus cluster, and also facilitate access to larger federally-funded clusters at zero cost. Provided data transfer and network performance monitoring services enable researchers and collaborators to move data quickly.
Web tool, developed by the U.S. National Cancer Institute (NCI), performs statistical modeling of cancer incidence or mortality data using age-period-cohort analysis. It allows users to examine and interpret temporal trends while disentangling the effects of age, calendar period, and birth cohort. The tool supports data import, graphical output, and model fit assessment via interactive web interface.
Cancer Incidence in Five Continents (CI5) is a collaboration between the International Agency for Research on Cancer (IARC) and the International Association of Cancer Registries (IACR) that produces a benchmark series of data on cancer incidence worldwide. This multi-volume publication, released approximately every five years, compiles standardized data on newly diagnosed cancer cases from population-based cancer registries across the globe. The data provide a unique source of comparable information on the global burden and distribution of cancer and help inform cancer control programs.
Agilent 7000E triple quadrupole GC/MS instruments incorporate intelligent technology that reduces instrument downtime and improves run times for maximum productivity in analytical labs. Mass spectrometer is used for routine, high-sensitivity analysis of targeted compounds in complex samples, especially for trace-level detection in areas like food safety and environmental testing.
High-performance scientific CMOS (sCMOS) digital camera designed for low-light microscopy and advanced imaging applications. Its key features include an exceptionally low and uniform readout noise, high quantum efficiency (QE) of up to 95%, and a patented "Lightsheet Readout Mode" optimized for light-sheet microscopy. This combination makes it ideal for detecting faint signals with high signal-to-noise ratios in challenging experiments, such as time-lapse, fluorescence, and single-molecule tracking.
General-purpose polarizing microscope designed for all polarization inspection tasks in the petroleum, mining, and structural characterization industries. It is also an all-round instrument suitable for industrial analysis and quality control , such as analyzing glass, plastics, textiles, and fibers, as well as inspecting display panels in the semiconductor industry.
NMR Core Facility is equipped with NMR spectrometers allowing researchers to Characterize bio-molecular structures at the atomic resolution with exquisite details;Identify protein interactions with binding partners in order to understand their architecture;Study protein dynamic;Study protein post-translational modifications acting as molecular switches;Study structure-function relationships of biological proteins to gain insight into biological processes in relation to human disease;Screening of High-throughput drug-like leads for novel therapeutic targets;Study Metabolites of interest.Core facility houses high-field NMR spectrometers equipped with cryogenically cooled probes (1H or 13C optimized) for enhanced sensitivity.
Facility provides training and access to advanced light microscopy systems at an hourly rate. In addition, we are available to consult with and support users at every stage of a project including: experimental design, sample preparation, image acquisition, analysis, and data preparation.
Genomics Core team has expertise in bacterial genomics, computational biology, infectious disease, HIV, population and conservation genetics. Offers NGS services. Capable of supporting projects at any stage, from planning to sample processing to sequencing. keith crandall