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Computer algorithm for ab initio protein structure prediction and protein peptide folding, which aims to construct correct protein 3D model from amino acid sequence only. Server is suitable for proteins that do not have homologous templates in PDB library.
Software R package to run minimum hypergeometric test.
Web prediction tool for molecular binding in simulation of immune system. Agent based simulator of immune response that represents pathogens, as well as lymphocytes receptors, by means of their amino acid sequences and makes use of bioinformatics methods for T and B cell epitope prediction.Calculates immune response to generic pathogenic secondary structure. Allows users to submit antigen protein sequence and specify schedule of its injection as well as host haplotype.
Software experimental data table management system to make research data accessible and available for reuse with minimal effort on part of data provider. Allows any scientist or data researcher to be able to explore dataset and then extract some or all of data according to their needs. Designed to manage experimental data tables in quick and easy way for users.
Provides data integrity using blockchain. Used for protecting integrity and provenance of research data.Open science chain utilizes distributed ledger technology (consortium blockchain) to securely store information about scientific data including its provenance to enable independent verification of its authenticity to establish trust in the research community.
Web tool for prediction of protein sorting signals and localization sites in amino acid sequencies. Recommended for animal/yeast sequences. Analyzes input sequence by applying stored rules for various sequence features of known protein sorting signals to report possiblity for input protein to be localized at each candidate site with additional information.
Software R package that predicts doublets in single cell RNA sequencing data. Doublet detection in single cell RNA sequencing data using artificial nearest neighbors. Identifies doublets using only gene expression data.
Software object oriented discrete event simulation tool for complex, data driven modeling. Open source, Python based object oriented discrete event simulation tool that makes it easy to use large, heterogeneous datasets and high level data science tools such as NumPy, Scipy, pandas, and SQLAlchemy to build and simulate complex computational models.
Database, part of 3Rs Database Programme, provides overview of FCS free media for cell culture. Forum function for each record allows researchers to discuss applicability of each product. Database is offered by 3Rs-Centre ULS in collaboration with Animal Free Research UK.
Web application to generate random DNA sequences.
Web application for combined transmembrane topology and signal peptide prediction. The predictor is based on a hidden Markov model (HMM) that models the different sequence regions of a signal peptide and the different regions of a transmembrane protein in a series of interconnected states.
Software Python package to link Brain Imaging Data Structure and MNE-Python software for analyzing neurophysiology data with goal to make analyses faster to code, more robust to errors, and easily shareable with colleagues. Provides programmable interface for BIDS datasets in electrophysiology with MNE-Python. Used for organizing electrophysiological data into BIDS format and facilitating their analysis.
Software Java based suite of tools for creation, annotation and display of RNA secondary structure diagrams.Provides editing tools for easy modification of publication quality secondary diagrams that can be either drawn manually, or through automatic generation. Other features include grouping, numbering and structure annotation. Secondary structures may be saved in native format, or exported as postscript for printing and further manipulation in programs such as Adobe Illustrator.
Unified web framework for Rosetta applications. Web interface for selected Rosetta protocols. Web front end for Rosetta software suite. Provides common user interface for Rosetta protocols, stable application programming interface for developers to add additional protocols, flexible back-end to allow leveraging of computer cluster resources shared by Rosetta Commons member institutions, and centralized administration by Rosetta Commons to ensure continuous maintenance. Offers general and speedy paradigm for serverification of Rosetta applications. Lowers barriers to Rosetta use for broader biological community.
Software system for solving protein structures using x-ray crystallographic data. Automatic molecular replacement pipeline for molecular replacement in CCP4. Integrates into one system all components necessary for solving crystal structure by Molecular Replacement. System is automated so that it needs no user intervention when running combination of jobs such as model searching, molecular replacement and refinement.
Includes 770 genes, including 13 internal reference genes for data normalization. Perform comprehensive multiplex gene expression analysis in human or mouse with 770 genes included for research of immunity and inflammation, neurobiology and neuropathology, and metabolism and stress. For research of neurodegenerative disease, traumatic brain injury, psychiatric disorders, neuropathic pain, CNS infection, and others. Comprehensive assessment of 23 neuroinflammation pathways and processes. Unique cell typing analysis feature measures the relative abundance of 19 CNS and peripheral immune cells. Customizable with Panel Plus option – add up to 30 genes of your choosing.
Includes 770 genes, including 10 internal reference genes for data normalization. Reproducibly translate mouse models of Alzheimer’s disease (AD) to human disease with 770 standardized genes covering 30 clinically derived AD-associated modules discovered in the AMP-AD consortium study of human brain tissue. Reliably assay AD phenotypes and disease progression for mouse model development and human tissue screening. Perform in vivo screening of potential therapeutics with an efficient and translational workflow to potentially reduce time to the clinic.
AxIS records and displays action potentials from neurons or cardiomyocytes on each electrode across the plate in real-time. View activity from every electrode on a well-by-well basis, or use plate-wide activity maps to get a broader picture of cellular activity at any time.
Portal for quantitative models using virus sequence variation to predict mutation effects for SARS-CoV-2 proteins, alignments to homologs in other viruses, 3D structures, evolutionarily coupled residues and structure predictions.
The Bio-Plex Pro Mouse Chemokine Panel 33-Plex Assay enables you to detect and quantify chemokines from mouse biological samples, requiring only 10 µl of precious sample. Whether you are studying oncology, immunology, autoimmunity, neurology, infectious diseases, or engaging in biomarker discovery, the Bio-Plex Pro Mouse Panel will provide a robust, efficient tool to screen even low-level analytes in a high throughput, multiplex assay. Chemokines tested for: BCA-1 / CXCL13, CTACK / CCL27, ENA-78 / CXCL5, Eotaxin / CCL11, Eotaxin-2 / CCL24, Fractalkine / CX3CL1, GM-CSF, I-309 / CCL1, IFN-γ, IL-1β, IL-2, IL-4, IL-6, IL-10, IL-16, IP-10 / CXCL10, I-TAC / CXCL11, KC / CXCL1, MCP-1 / CCL2, MCP-3 / CCL7, MCP-5 / CCL12, MDC / CCL22, MIP-1α / CCL3, MIP-1β / CCL4, MIP-2 / CXCL2, MIP-3α / CCL20, RANTES / CCL5, MIP-3β / CCL19, SCYB16 / CXCL16, SDF-1α / CXCL12, TARC / CCL17, TECK / CCL25, TNF-α