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Core provides sequencing using Illumina next-generation sequencing and ONT long read technologies. Offers library preparation services for genomes, exomes, transcriptomes, and ChIP-seq experiments, expertise on the best approach for samples, depending on the quality of nucleic acids, scope of project, and available budget.
Software R code to apply Stages of Reproductive Aging Workshop + 10 stages to prospectively collected vaginal bleeding data among a cohort of Black women aged 40–55 years. Used to apply STRAW+10 stages to prospectively tracked menstrual bleeding data in a longitudinal cohort study of perimenopausal women.
Core provides expertise in radiochemistry, PET tracer development, preclinical PET and MRI imaging, cancer modelling, and advanced image analysis. Supports translational imaging research, with strengths in molecular imaging, pharmacodynamic biomarker development, and AI-enabled image analytics. Provided instruments include a GE PETtrace 800 cyclotron, radiosynthesis platforms, and small-animal NanoScan PET/MRI system. Services include expertise in both PET and MRI acquisition and analysis, supporting studies in cancer biology, metabolism, and therapy response.
Software tool for predicting protein functional association by analysis of conservation of genomic contex. Takes a list of NCBI protein accessions as input, clusters neighbourhood-encoded proteins into homologous groups using sensitive sequence searching, and outputs a graphical visualization of the gene neighbourhood and its conservation, along with a phylogenetic tree annotated with flanking gene conservation.
Concentrator with UVS850DDA Universal Vacuum System is designed for solvent removal and sample concentration with integrated vacuum control and refrigerated/condensation components. Used to quickly evaporate or remove solvents from samples. It combines vacuum pressure, mild centrifugation, and heat to safely concentrate biological and chemical samples without risking degradation.The DDA (Dual-valve Dual-application) designation means it is specifically chemically resistant and rated for aggressive conditions.
Software R package and web application designed for the quality control (QC), exploratory data analysis (EDA), visualization, and statistical analysis of complex biological omics data. Provides functionality for quality control processing and statistical analysis of mass spectrometry (MS) omics data, in particular proteomic (either at the peptide or the protein level), lipidomic, and metabolomic data, as well as RNA-seq based count data and nuclear magnetic resonance (NMR) data. This includes data transformation, specification of groups that are to be compared against each other, filtering of features and/or samples, data normalization, data summarization (correlation, PCA), and statistical comparisons between defined groups.
Software platform by Thermo Fisher Scientific designed for identifying, comparing, and interpreting small molecules in complex biological, environmental, and forensic samples. It uses customizable workflow, known as nodes, to automate mass spectrometry data processing, spectral library searching, and statistical analysis.Compound Discoverer is integrated with SIRIUS (via a custom workflow node) to bridge the gap between high-resolution MS/MS data and confident molecular identification. While Thermo Scientific’s Compound Discoverer excels at library searching and statistical analysis, SIRIUS provides powerful in silico tools to accurately predict molecular formulas, chemical classes, and de novo structures. High-resolution mass spectrometry (HRMS) data analysis software for untargeted metabolomics, lipidomics, and contaminant screening. Utilizes modular workflows to extract features, match spectra against libraries like mzCloud, and confidently identify complex organic compounds.
Software tool as peptide retention time predictor using peptide encoding based on atomic composition that allows the retention time of (previously unseen) modified peptides to be predicted accurately. Retention time prediction for peptides.
Web tool and predictive model used by researchers to identify which small protein fragments (peptides) will be presented by human leukocyte antigen (HLA) proteins on the surface of cells. It is heavily used in the development of cancer immunotherapies and personalized
Core offers standard and specialised histology services including tissue processing (murine, human and Drosophila tissue), processing of cellular material (cells, crypt cultures, organoids and spheroids), microtomy, cryo-microtomy, haematoxylin and eosin and specialised tissue stains along with automated immunohistochemical/ immunofluorescence/ in situ hybridisation analysis for specific labelling of individual tissue constituents.
Molecular and analytical core that provides full service genomic library preparation, high-throughput DNA/RNA extractions and small molecule analysis, and serves as a bio-repository of microbes and experimental arthropod models.
Database provides age specific reference templates and segmented brain volumes for participants ranging from 2 weeks to 89 years of age. It is highly utilized for pediatric and lifespan neurostructural studies to prevent misspecifications caused by using adult only templates. Consists of average MRI templates, segmented partial volume estimate volumes for GM, WM, T2W-derived CSF. The database is separated into head-based and brain-based averages. The data are separated by ages in months, years, 6-month, or 5-year intervals. The templates are grouped into first year (2 weeks through 12 months), early childhood (15 months through 4 years), childhood (4 years through 10 years), adolescence (10.5 years through 17.5 years) and adults (18 years through 89 years). Tools for cortical source analysis of EEG and ERP are provided. These tools are based on the average MRI templates, segmenting, and atlases.
Atlas provides a comprehensive framework for dissecting hormonal impact on health and disease. Maps the human endocrine system. Provides a comprehensive map of over 14 million cells to track hormonal signaling. A single cell map uses single cell transcriptomics to map hormone production and action across 47 disease-free human tissues at cellular resolution.
A single cell map uses single cell transcriptomics to map hormone production and action across 47 disease-free human tissues at cellular resolution.
Software toolkit for predicting hormone producing and receiving strength in single cell datasets.
Mass spectrometer for advanced, high-speed, and deep-coverage biological research, specifically targeting proteomics, clinical biomarker discovery, and single-cell analysis. It combines high-resolution accuracy with a rapid scan speed of up to 200 Hz. Powered by the synergy of the high resolution quadrupole mass filter, Thermo Scientific™ Orbitrap™ mass analyzer and the novel Thermo Scientific™ Astral™ mass analyzer. The combination of these three mass analyzers enables the acquisition of quality high resolution accurate mass (HRAM) data with high sensitivity and dynamic range.
Software for collecting, analyzing, and reporting life science data. Used to control inhalation exposure systems, track real-time animal respiration, and calculate precise delivered drug doses in pre-clinical research. It automates aerosol delivery, monitors lung function data, and manages experimental protocols.
Core provides analytic expertise and infrastructure needed to transform complex spatial data into actionable insights to support cancer research, precision population health, learning health system interventions and policy and resource planning at institutional and regional levels.
Core specializes in artificial intelligence-based approaches to elucidate relationships between large imaging, bioenergetics, genomic, and proteomic data sets. Provided services include: 1) foundational training for those getting started with high-performance computing and Arkansas Research Platform (ARP), 2) training and support for the collaborative use of a 508 TB data storage server exclusively maintained for and catering to AIMRC researchers, 3) training for Python programming, basic data mining, and machine learning, 4) training and support for using open-source deep learning based biomedical imaging resources (e.g., ZeroCostDL4Mic and Bioimage Model Zoo), and 5) customized solutions for deep learning based and large foundational models based biomedical imaging analysis, multi-omics data integration and analysis, and quantitative analysis pipelines for large data sets.
Core supports mechanistic human laboratory studies and randomized clinical trials by identifying, coordinating, and providing the scientific expertise, clinical and technical capabilities, and other resources needed for their research projects.