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Microscopy Core for high resolution imaging and aims to make this technology accessible to neuroscientists and other scientific researchers.Provides advanced systems for cellular and molecular imaging of in vitro and in vivo samples, implements new imaging technologies, particularly related to real time and tissue clearing based imaging of neurodevelopment and neural functions, offers training, consultation, data analysis, image processing, and centralized technical expertise.
Portal for research on urinary stones in adults and children in order to learn more about who forms kidney stones, treatments and prevention. Network comprises of experts including adult and pediatric urologists, adult and pediatric nephrologists, pediatricians, emergency department physicians, clinical trialists, nutritionists, behavioral scientists, and radiologists. Duke Clinical Research Institute is Scientific Data Research Center and with clinical sites including University of Pennsylvania Children Hospital of Philadelfia, University of Texas Southwestern Medical Center, University of Washington, Washington University in St. Louis, work together in planning, executing, and analyzing results from USDRN studies.
Software tool for distributed dimensionality reduction and visualization. Distributed software for visualizing intrinsic structure of large scale single cell data written in C language. Its distributed storage and distributed computation technique allows efficiently analyze large scale single cell data at cost of constant time speedup.
Provides single particle cryo EM and cryo tomography of plunge frozen samples. Using Titan Krios G3i for high resolution data collection on Gatan K3 Direct Detection Camera facility is able to offer data collection at atomic level resolution.Facility uses Serial EM for SPA and cryo-ET data acquisition.
Software tool accepts image files (like PNG, JPEG and TIFF) containing graphs, and recovers the data points from those graphs. Used to convert graphs to data points. Imports image file and then digitizes it by placing points along axes and curves.
Software general R package providing standard methods for meta analysis.
Software package serves as companion R package for online guide Doing Meta-Analysis in R - A Hands-on Guide written by Mathias Harrer, Pim Cuijpers, Toshi Furukawa and David Ebert. Guide shows how to perform meta-analyses in R from scratch with no prior R knowledge required.
Software Python package part of nonnegative matrix factorization NMF. Features various classification, regression and clustering algorithms including support vector machines, random forests, gradient boosting, k-means and DBSCAN, and is designed to interoperate with Python numerical and scientific libraries NumPy and SciPy.
Software tool for macromolecular structure visualization. Molecular visualization framework to visualize crystallographic models of macromolecules. Used to visualize and create publication quality images of macromolecular structures with user friendly interfaces.
Core facility responsible for custom adeno-associated virus (AAV) and lentivirus production available through Canadian Neurophotonics Platform. Services include design, cloning and production of molecular constructions in order to produce plasmid expression vectors or to generate transgenic animals and design, including advice and assistance for choice of suitable vectors required by investigators.
Web based gene expression database and analysis platform. Used for integrative data mining of genotype and phenotype data, with optimized workflows.
Core provides instruments including Scanalyzer 3D platform which consists of multiple digital imaging chambers connected to controlled environment Conviron growth house by conveyor belt system, resulting in continuous imaging loop and enables repeatedly image plants at multiple points throughout time.RGB imaging allows visualization and quantification of plant color and structural morphology. Near-infrared (NIR) enables visualization and quantification of plant water-use efficiency.Watering and weighing stations are customizable to deliver water and nutrients on specified schedule by volume or weight. Standard phenotyping services include operation and maintenance of LemnaTec Scanalyzer system, as well as technical support and troubleshooting.
Core helps researchers investigate interactions between small molecules and biological systems by providing medicinal chemistry and chemical biology expertise and organic synthesis support.
Refrigerated benchtop microcentrifuge with rotor designed to provide acceleration up to 21,100xg.
Microprocessor based, programmable ultrasonic processor. Features include pulse mode and digital display of both wattage and joules.Used for standard cell disruption, DNA/RNA shearing, homogenization and many other applications.
Software tool as regularization technique that penalizes L2-norm of coefficients in linear regression. Available in two programming languages MATLAB and Python.
Web server is focused on protein ligand interactions. Provides support for initial steps when dealing with protein structures, namely structure search, quality assessment, and preprocessing. Furthermore, advanced options, such as protein pocket detection, ensemble generation or prediction of metal coordinations are supported.
Software tool to check stereochemical quality of protein structures. Its outputs comprise number of plots in PostScript format and comprehensive residue by residue listing. Includes PROCHECK-NMR for checking quality of structures solved by NMR.
Web server for protein subcellular localization prediction with functional gene ontology annotation. Web based system for screening various properties of targeted protein and its subcellular localization.
Software tool as molecular graphics program designed to give straightforward and complex static and dynamic representations of macromolecular structures. Used to create publication quality images and movies and to superpose and analyse structures.