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Mass Spectrometry Core provides comprehensive LC-MS and MALDI imaging MS based analytical support for proteomics, lipidomics, metabolomics, glycomics, and spatial omics. Offers expertise in experimental design, optimized sample preparation, data acquisition, data analysis, and investigator training for NIH funded and translational research projects.
Fluorescence stereomicroscope offers 3D image, larger panoramic field of view, more intense fluorescence, and longer working distances. Living objects can be observed spatially in large fields of view.
Software R package for estimating dim-light melatonin onset (DLMO), implementing the hockey-stick method. Establishes a reproducible and sustainable foundation for melatonin-based circadian phase estimation and a modular platform for incorporating future quantitative approaches to DLMO detection.
Web-based, and open-source platform designed to predict and optimize CRISPR-Cas13 guide RNAs (gRNAs) for targeting and knocking down specific RNA molecules. It is specifically used to select the most efficient guide RNAs for RfxCas13d to maximize RNA degradation (knockdown) efficacy, with applications in transcriptome engineering, functional genomics, and antiviral therapy.
Bioinformatics software program for multi-omics data analysis and visualization. It is developed and maintained by Qlucore AB (Lund, Sweden). Delivers flexible and easy-to-use visualization of big data for fast analysis and results.
Core has personnel with expertise in all aspects of Mass Spectrometry Imaging. Provides spatial mapping of biomolecules from tissue sections using Matrix Assisted Laser Desorption/Ionization (MALDI) and Secondary Ion Mass Spectrometry (SIMS).
Core provides cell analysis, sorting instruments and expertise in regular fluorescence, spectral, and flow cytometry. Offers educational and cytometric services including stem cell analysis, immunophenotyping, cell cycle analysis, translocation and co-localisation of cell activation markers, chromatin density, and apoptotic and necrotic analyses. Performs cell sorting, expertise in experimental design and provides equipment training for all users.
Ultra-rapid, high-throughput, high insight system for multiplex immunofluorescence (IF) and biomarker discovery. System enables to perform highly-multiplexed imaging of entire cross sections with sub-cellular resolution. Fully automated workflows for tissue staining and imaging. A full-stack hyperplexing solution capable of visualizing up to 40 markers.
Automated, microwave-based instrument designed to perform rapid deparaffinization, rehydration, and antigen/nucleic acid retrieval on formalin-fixed, paraffin-embedded (FFPE) tissue sections. It handles up to 96 slides in 30 minutes, utilizing infrared (IR) technology for consistent, high-throughput staining.
Core lab aids researchers in the design, compliance, methods, extractions, data analyses and training in microbiome research and innovation. Premier resource center, equipped with instrumentation, analytical capabilities, and training opportunities in microbiome.
This dataset includes human brain stimulated-echo (STE) diffusion MRI (dMRI) images acquired at the long diffusion time of 1 second from 10 healthy volunteers and an ex vivo brain hemisphere, as described by Aganj et al (MRM 2026). Also included are MPRAGE T1 images for all scans and standard dMRI images for the 10 in vivo scans. All images have been anonymized, and the T1 images have been de-faced.
Field Research Site is a core facility providing scientists with advanced field research infrastructure and crop management capabilities. Offers diverse agricultural practices including full tillage, no-till systems, irrigation, precision spraying, and plot planting for row crops and specialty crops. On-site resources include multiple drying rooms, walk-in freezers, and dedicated processing spaces for soil, tissue, and seed samples.
Software command-line tool designed to simulate circular DNA and RNA sequences and generate corresponding sequencing reads. This tool can be helpful for researchers working with circular DNA (like eccDNA) or RNA, providing an easy way to simulate the coordinates of these molecules and generate sequencing files for further analysis.
Web application to explore somatic mutations in large breast cancer RNA-sequencing datasets, particularly from the Sweden Cancerome Analysis Network–Breast (SCAN-B) project, helping to link genetic alterations to clinical features, patient outcomes (like survival), and potential drug targets, adding a dimension to gene expression analysis for guiding treatment.
Electron microscopy core provides microscopy and image analysis, applications development, and services.
Interactive database and user interface providing online access to validated alternative methods for U.S. regulatory and other contexts of use. Central hub and unified resource of validated alternative methods that enhances accessibility to validation study reports, data, protocols / SOPs, and information on regulatory guidance.Users can filter searches by alternative method types, defined approaches, Test Method Endpoint, and regulatory guidance.
Software package for quantifying transposable elements at a locus level for RNAseq datasets. TElocal base algortihm is derived from the published TEtranscripts tool.
As part of the cellular engineering and vectorology core facility (ICV), the iPSC core facility (ICV-iPS) proposes the generation and the genetic engineering of human induced pluripotent stem cells to internal research teams, external academic teams, and industrial partners. Services include generation of human iPSc with Sendai virus, full molecular and functional characterization of iPSc clones, genetic engineering of human iPSc with CRISPR/Cas9 system and theoretical and practical learning sessions on human iPSc culture. The core facility provides also access to L2 cell culture box dedicated to human iPSc culture.
Software application for fast phylogenetic maximum parsimony tree inference and bootstrap approximation.
Web application for facilitating compliance with the minimal data standards (MDS) set by the open data commons for SCI and TBI.