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Core provides services for generation and characterization of induced pluripotent stem cells (iPSCs) from somatic sources such as blood and fibroblasts, along with long-term cryobanking. Offers access to collection of well-characterized iPSC lines derived from both healthy donors and patients with various diseases, representing a range of ethnic backgrounds and sexes.Major focus of core is gene editing in pluripotent stem cells, with expertise in CRISPR-based applications from precise point mutation knock-in (correction or introduction) to the generation of reporter lines (e.g., GFP and other fluorescent reporters) and inducible systems such as Cre-lox, dTAG, and beyond.Core provides guidance and support for the differentiation of iPSCs into multiple cell types, using both monolayer and 3D organoid formats, enabling downstream disease modeling and functional studies.

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• SciCrunch
• 1 year ago - submitted by Edyta Vieth

R package for quantifying variation in DNA methylation as a cancer biomarker.

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• SciCrunch
• 13 years ago - by Anonymous

Public research university in St. Louis County, Missouri.

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• SciCrunch
• 16 years ago - submitted by Andrea Stagg

AMDL is a clinical CAP/CLIA accredited molecular diagnostics laboratory at the Princess Margaret Cancer Centre. Supports clinical trials and translational research projects requiring clinical-grade (CAP/CLIA) molecular testing at Princess Margaret Cancer Centre. AMDL works closely with Molecular Diagnostics lab in Toronto General Hospital to transition protocols into clinical tests.

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• SciCrunch
• 1 year ago - submitted by Edyta Vieth

Ikaros is an open infrastructure for system level modeling of the brain including databases of experimental data, computational models and functional brain data. The system makes heavy use of the emerging standards for Internet based information and makes all information accessible through an open web-based interface. In addition, Ikaros can be used as a control architecture for robots which in the extension will lead to the development of a brain inspired robot architecture. The main components of the Ikaros systems are: a platform independent simulation kernel; a set of computational brain models; a set of I/O modules for interfacing with data files and peripheral such as robots or video cameras; tools for building systems of interconnected models; a plug-in architecture that allows new models to be easily added to the system; and a database with data from learning experiments that can be used for validation of the computational models.

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• SciCrunch
• 17 years ago - by Anonymous

NIDDK center that serves diabetes-oriented investigators from University of Pennsylvania as well as additional institutions from the mid-Atlantic region. The Penn DRC represents many basic science and clinical departments at Penn and the other institutions, and supports research in diabetes and obesity via Scientific Cores, a Pilot and Feasibility Grant Program, and a series of seminars, retreats, and other academic enrichment activities.

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• RRID-Legacy
• 9 years ago - submitted by Anita Bandrowski

Core offers a fully functional tissue culture facility with specialized instruments, media, reagents, cell lines, and expertise for new or established researchers to perform cutting-edge stem cell research. In addition, our core provides comprehensive human induced pluripotent stem (iPS) cells related training, consultations, and standard and customized scientific services, including derivation of iPS cells, differentiation of iPS cells and genome editing in iPS cells to stem cell researchers.

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• SciCrunch
• 1 year ago - submitted by Edyta Vieth

Collects and stores genetic (DNA) samples along with associated healthcare information from patients of Northwestern-affiliated hospitals and clinics. This resource is available to scientists to conduct groundbreaking genetic research. The information and blood samples provided will be used by researchers to examine the role genes play in the development and treatment of common diseases. The NUgene Project seeks to increase the understanding of genetic mechanisms underlying common diseases, assist in the development of DNA-based technology for diagnosis and treatment of disease, and aid physicians and other healthcare providers in the application of genetics to the practice of medicine. NUgene participants are recruited throughout the Northwestern-affiliated healthcare community in order to create an ethnically and medically diverse population for research. Participants must be 18 years of age or older and receive their medical care from a Northwestern-affiliated provider, regardless of health status. Consenting individuals complete all aspects of enrollment in a single meeting with a research coordinator. The enrollment process includes the donation of a single sample of blood and the completion of a self-administered questionnaire. Participants also sign a consent form during this encounter. The NUgene Project is an interdisciplinary project that relies on the expertise of individuals working in a variety of fields, including science, medicine, clinical research, statistics, epidemiology, and computational biology. NUgene''s multidisciplinary approach has spurred collaborations within Northwestern-affiliated institutions and with other outside institutions. This collaboration of ideas is the future of genetics and genomic research., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025.

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• SciCrunch
• 17 years ago - by Anonymous

Public healthcare network in Sherbrooke, Quebec, Canada, affiliated with the Université de Sherbrooke Faculty of Medecine.

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• SciCrunch
• 14 years ago - submitted by Andrea Stagg

Core has built technology toolbox with access to and application of novel and existing methods in multitude of genomics technologies. These capabilities span bulk, single-cell, spatial, and in situ genomic sequencing methods, all of which are leveraged to generate complementary cross-platform, orthogonally validated datasets to foster novel discovery and advance clinical applicability using human cohorts and model systems

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• SciCrunch
• 1 year ago - submitted by Edyta Vieth

ChromDB is a chromatin database. Three types of sequences are included in the database: genomic-based (predominantly plant sequences); transcript-based (EST contigs or cDNAs for plants lacking a sequenced genome); and NCBI RefSeq sequences for a variety of model animal organisms. The Gene Record Page for any sequence indicates the type of sequence. The broad mission of ChromDB is display, annotate, and curate sequences of two broad functional classes of biologically important proteins: chromatin-associated proteins (CAPs) and RNA interference-associated proteins. Plant proteins are the major focus of the work support by The Plant Genome Research Program (PGRP) of the National Science Foundation. Our intent is to produce intensively curated sequence information and make it available to the research and teaching community in support of comparative analyses toward understanding the chromatin proteome in plants, especially in important crop species. In order to do a comparative analysis, it is necessary to include non-plant proteins in the database. Non-plant genes are not curated to the degree carried out for plants and to automate the process of data import, our non-plant genes are from the RefSeq database of NCBI. We reason that the inclusion of non-plant, model organisms will broaden the relevance and usefulness of ChromDB to the entire chromatin community and will provide a more complete data set for phylogenetic analyses in support of the evolution of the plant chromatin proteome. ChromDB is funded by a grant from the National Science Foundation Plant Genome Research Project(#DBI-0421679).

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• SciCrunch
• 17 years ago - by Anonymous

Public university in Surrey, UK that provides undergraduate, master's, doctoral, professional, and research degree programs.

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• SciCrunch
• 13 years ago - submitted by Andrea Stagg

Core has resources available at Fred Hutch and UW in collaboration with multi-disciplinary imaging research groups specializing in respective imaging technologies. Provides services including: support for animal imaging; consultation for appropriate use of imaging; training and education; help with protocol development; infrastructural support; and strategic acquisition of new imaging equipment. Provides animal imaging equipment, including MRI, PET, US and optical to support scientific projects within the UW-FH Cancer Consortium.

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• RRID
• 1 year ago - submitted by Cassie Sather

The Human BAC Ends Database is a database of sequences from the ends of bacterial artificial chromosome (BAC) clones. A whole genome sequencing approach has been described in a map-as-you-go strategy. The complete sequence of a seed BAC is searched against a BAC end database and the minimally overlapping clones in each direction are selected for sequencing. As coverage increases, BAC end sequences provide samples for whole genome survey. It currently contains 743,000 end sequences from 470,000 clones (20 X clone coverage and 12% sequence coverage), generated by TIGR, UofWashington and CalTech, providing a sequence marker every 5 kb across the genome. The coverage by paired-ends on chromosome 22 is over 5X. The project is funded by DOE.

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• SciCrunch
• 17 years ago - by Anonymous

University of Washington is public research university in Seattle, Washington. Has university campuses in Seattle, Tacoma and Bothell, academic medical center and professional and continuing education programs.

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• SciCrunch
• 17 years ago - submitted by Timothy Tsui

Tulane University School of Medicine Department of Microbiology/Immunology Flow cytometry and cell sorting shared resource facility. Provides education, training and services, Applications include analysis and sorting of immune subsets and fluorescent-reporter expressing cells, DNA content, multi-plex bead assays and functional assays. Expert assistance with experimental design and data analysis, as well as instrument training, are available at no charge.

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• RRID
• 1 year ago - by Anonymous

NMP-db is a database of nuclear matrix associated proteins. The NMP-db consists of two parts. The first part is the actual literature based NMP-db, containing all nuclear matrix proteins (NMPs) that were originally found in PubMed. The second part is a database of homologues to the NMP-db proteins. This database is called NMP-db(hom) and contains proteins which have at least an HSSP-value of 55 to one of the proteins in the NMP-db. The NMP-db holds informations about the protein names, their organism and the cell-type in which NM association was observed. Also links to the respective PubMed abstracts are given in each entry. Additionally, we provide information about predictions of secondary structure, solvent accessibility, coiled-coil regions and domain-architecture, as well as the sequence, links to PDB (database of 3D-structures), molecular weight, theoretical pI, links to SWISS-2DPAGE, OMIM, PEP and many other databases. If available, we also list regions in a protein sequence that are known to be cruicial for NM-targeting. Finally, links to the S/MARt DB allow users to find DNA-regions that bind to NMPdb proteins.

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• SciCrunch
• 17 years ago - by Anonymous

Confederal university based in Cardiff, Wales. Founded by Royal Charter in 1893 as a federal university with three constituent colleges – Aberystwyth, Bangor and Cardiff – the university was the first and oldest university in Wales, one of the four countries in the United Kingdom.

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• SciCrunch
• 14 years ago - submitted by Stephen Larson

Software repository contains files needed to build the standard and its supplementary documentation. Changes are automatically pushed and built. Information about the SWC file specification.

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• RRID
• 1 year ago - submitted by Anita Bandrowski

Memorial Sloan-Kettering Cancer Center''s ontology of surgical secondary events (adverse events).

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• SciCrunch
• 13 years ago - by Anonymous