Curator Dashboard

Core provides access to advanced imaging and analytical instrumentation, expert technical support, hands-on training, and collaborative project support. Services include high-resolution imaging through Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy (TEM) to examine surface features, internal structures, microstructures, nanoparticles, biological specimens, and engineered materials at micro- to nanoscale resolution; X-Ray Diffraction (XRD) for phase determination and crystallographic analysis; Atomic Force Microscopy (AFM) for nanoscale surface characterization. Provides solid analyzer and rheometer for evaluating material properties and behavior. Specialized sample preparation services include polishing, ultramicrotomy, sputter coating, and other preparation techniques needed for microscopy and materials analysis. Individualized, non-credit instruction is available for instrument operation and sample prep techniques. Offers expert support with sample preparation, data acquisition, sample analysis, troubleshooting, and preparation of results for reports, proposals, presentations, and publications.

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• 6 months ago - submitted by Rooban Venkatesh K G Thirumalai

Micro X-ray Computed Tomography Shared Research Facility (XCT-SRF) provides access to an X-ray microscope and micro-CT instrument, and expertise in experiment planning, sample preparation, and data analysis and visualisation. The facility is capable of 3D imaging and analysing a wide range of material samples, with a focus on supporting research in healthcare, manufacturing, and energy applications.

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• 6 months ago - submitted by Julia Behnsen

Instrument to increase the rate of tissue clearing. Provides optimal imaging and staining quality. Delipidates for best antibody diffusion and minimal light scatter, and ensures maximum preservation of fluorescent protein signals with optimized buffers that maintain pH. Nanoporous membranes prevent common issues including tissue damage, contamination, browning, black precipitates, and deformation.

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• 6 months ago - submitted by Anita Bandrowski

Software bioinformatic framework for reconstructing 4D spatial transcriptomics atlas and spatiotemporal analyses+.

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• 6 months ago - submitted by Guo Lidong

Software tool for cell type specific enhancer-gene predictions using ABC model.

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• 6 months ago - submitted by Edyta Vieth

Software tool for assigning statistical confidence estimates to chromosomal contact maps produced by genome-wide genome architecture assays such as Hi-C.

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• 6 months ago - submitted by Edyta Vieth

Software supervised learning framework for chromatin loop detection in genome-wide contact maps.

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• 6 months ago - submitted by Edyta Vieth

Standardized, open-source framework of classes and properties designed to annotate and interlink data regarding metabolites, species taxonomy, ecological traits, and environmental interactions. It powers the METRIN-KG knowledge graph, mapping the chemical diversity of Earth's species to support biodiversity conservation. Knowledge representation schema designed to capture, contextualize, and structure chemical diversity data across all known species. It reuses and harmonizes several existing ontologies, while introducing over 100 new concepts and relations to enable interoperability and data reuse.

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• 6 months ago - submitted by Disha Tandon

Software pipeline for generating knowledge graph integrating emi, trydb, globi datasets. Code for constructing a knowledge graph that integrates enriched metabolite data from Experimental Natural Products Knowledge Graph (ENPKG), LOTUS (available through Wikidata), plant trait data from TRY, and biotic interaction data from Global Biotic Interactions (GloBI). It performs taxonomic alignment against Wikidata records and generates Resource Description Framework (RDF) triples representing taxonomic relationships, traits, and species interactions. The resulting knowledge graph is queryable via a SPARQL (SPARQL Protocol and RDF Query Language) endpoint.

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• 6 months ago - submitted by Disha Tandon

Knowledge base platform that provides scientists worldwide with tools for searching, exploring, and visualizing Neuroscience knowledge represented by knowledge graphs (KGs). Provides tools that enable scientists to contribute new information (or knowledge) to the platform and is expected to be a go-to destination for all neuroscience-related research needs. Allows making predictions and new inferences in addition to querying and viewing information.

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• 6 months ago - submitted by Anita Bandrowski

Mouse Biology Shared Resource (MBSR) provides knockout, transgenic, and humanized murine cancer models and related services for advancing translational cancer research. Additionally, the MBSR offers services to enhance the use of existing mouse models or to facilitate the development of new mouse models for cancer research, including genetic alteration (e.g., CRISPR/Cas9-mediated gene targeting, transgenesis), surgical manipulation (e.g., patient-derived xenografts (PDX), cell-derived allografts (CDA) and xenografts (CDX)), and environmental challenges (e.g., diet, chemotherapeutic agents). can produce a wide range of allele-speci?c mouse models and offers innovative technologies to phenotype mouse models that mimic human conditions.

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• 6 months ago - submitted by Edyta Vieth

Molecular Pharmacology and Chemical Biology Shared Resource (MPCBSR) provides services for the assessment of new therapeutics, including clinical trial specimens and determination of clinical PK/PD and potential drug-drug interactions (DDI), pharmacological studies on novel therapeutics in preclinical models, including DM/PK/PD, on-target mechanisms, biomarkers, and combination effects, and chemical synthesis of new compounds and drug delivery nanomaterials for improved therapy.

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• 6 months ago - submitted by Edyta Vieth

Software R package from the Allen Institute designed to build, standardize, and analyze single-cell RNA-seq-based cell type taxonomies. It utilizes a structured Allen Institute schema (AIT) to organize cell annotations and metadata, enabling hierarchical, data-driven cell type classification

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• 6 months ago - submitted by Carol Thompson

General, open-standard schema for cell annotations and related metadata. Provides programmatically accessible standard designed to record additional metadata about individual cell type annotations, including marker genes used as evidence and details of automated annotation transfer. Standard is represented as JSON schema as this allows all metadata to be gathered in a single, compact validatable file - which includes a link to a cell by gene matrix file of annotated data. However, the schema is designed so that it can be decomposed into individual tables suitable for use in dataframes/TSVs and flattened onto obs in AnnData format.

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• 6 months ago - submitted by Edyta Vieth

Mass Spectrometry Core provides comprehensive LC-MS and MALDI imaging MS based analytical support for proteomics, lipidomics, metabolomics, glycomics, and spatial omics. Offers expertise in experimental design, optimized sample preparation, data acquisition, data analysis, and investigator training for NIH funded and translational research projects.

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• 6 months ago - submitted by Kazuhiro Aoki

Fluorescence stereomicroscope offers 3D image, larger panoramic field of view, more intense fluorescence, and longer working distances. Living objects can be observed spatially in large fields of view.

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• 6 months ago - by Anonymous

Software R package for estimating dim-light melatonin onset (DLMO), implementing the hockey-stick method. Establishes a reproducible and sustainable foundation for melatonin-based circadian phase estimation and a modular platform for incorporating future quantitative approaches to DLMO detection.

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• 6 months ago - by Anonymous

Web-based, and open-source platform designed to predict and optimize CRISPR-Cas13 guide RNAs (gRNAs) for targeting and knocking down specific RNA molecules. It is specifically used to select the most efficient guide RNAs for RfxCas13d to maximize RNA degradation (knockdown) efficacy, with applications in transcriptome engineering, functional genomics, and antiviral therapy.

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• 6 months ago - by Anonymous

Bioinformatics software program for multi-omics data analysis and visualization. It is developed and maintained by Qlucore AB (Lund, Sweden). Delivers flexible and easy-to-use visualization of big data for fast analysis and results.

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• 6 months ago - by Anonymous

Core has personnel with expertise in all aspects of Mass Spectrometry Imaging. Provides spatial mapping of biomolecules from tissue sections using Matrix Assisted Laser Desorption/Ionization (MALDI) and Secondary Ion Mass Spectrometry (SIMS).

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• 6 months ago - by Anonymous