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High-sensitivity, compact benchtop tandem quadrupole mass spectrometers designed for trace-level quantification in complex samples. Primarily used for PFAS testing, pharmaceutical bioanalysis, clinical diagnostics, and environmental contaminant analysis, offering enhanced performance for negative ion-mode compounds. Used for quantifying drug residues, metabolites in biological samples, and impurities, with specific IVD models available for clinical settings. Equipped with StepWave XR technology to handle high-throughput, complex matrix samples with minimal maintenance.

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• 6 months ago - by Anonymous

Core offers large-animal experimental hybrid operating room equipped for cardiological and cardiothoracic interventions, including advanced angiography and multimodal intraprocedural imaging, to support patient-oriented preclinical research and education. Facility enables design, conduct, and veterinary-supervised aftercare of acute and chronic large-animal studies and hands-on training courses on implants, ventricular assist devices, artificial hearts, and percutaneous procedures for structural heart valve disease at phantom models and large-animal models. Core functions and services Performance of animal experimental studies and training courses in an experimental hybrid OR environment. Consultation on study design, model selection, and preparation of animal experiment applications for regulatory approval. Provision of anesthesia and surgical assistance, including perioperative and intensive care support. Specialist veterinary support for acute and chronic studies, ensuring animal welfare and scientific quality. Housing and husbandry for large laboratory animals such as sheep, pigs, and minipigs as part of the experimental program. Equipment and technology Hybrid operating room with Philips Allura Clarity FD20 angiography system tailored to cardiology and cardiac surgery interventions. Comprehensive software tools including Echo-, Heart-, and Vesselnavigator for image-guided procedures. EPIQ7 and CX50 ultrasound systems supporting TTE, TEE, ICE, and IVUS imaging modalities for structural and interventional procedures. Carto-3, OPTIS Integrated System, and XperCT platforms for 3D mapping and intravascular or intracardiac imaging. Heart–lung machine and ECMO systems for cardiopulmonary support during complex experimental interventions. Organizational context and availability Located at Campus Virchow-Klinikum as part of the Forschungseinrichtungen für Experimentelle Medizin and operated in cooperation with the Deutsches Herzzentrum Berlin. Provides core facility research infrastructure of the Charité faculty for translational cardiovascular research and advanced training in a large-animal setting. Certified according to ISO 9001:2015, indicating a documented quality management system for its services.

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• 6 months ago - by Anonymous

Facility for high resolution imaging of biological samples at cryogenic temperatures. Amongst other applications such as single particle data collection, our high-end instrumentation is suited to perform in situ structural biology by combining cryoCLEM, lamella FIB-milling, and cryo-electron tomography.

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• 6 months ago - by Anonymous

Core provides services supporting generation, modification, cryopreservation, and rederivation of genetically modified rodent models for biomedical research, generates genetically modified mouse models via both targeted and random mutagenesis using tools such as CRISPR/Cas9 in zygotes or embryonic stem (ES) cells, provides cryopreservation and rederivation of existing animal models to preserve hygienic integrity. Services for rodent transgenic model development include: Pronuclear Injection and amp; Viral Transgenesis with introduction of genetic constructs into zygotes using microinjection or lentiviral systems; ES Cell-Based Techniques: use of embryonic stem cell manipulation for genetic targeting; Embryo Transfer: transferring manipulated embryos into recipient females; In Vitro Fertilization (IVF): assisted reproductive technology to generate embryos for manipulation or cryopreservation; Cryopreservation: freezing of embryos and sperm for archiving or rederivation of lines as required. Facility’s expertise includes quality control of cryopreserved material to ensure viability upon thawing.

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• 6 months ago - by Anonymous

Software open AI-Powered Platform for 2D Temporal Plant Phenotyping.

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• 6 months ago - submitted by Rafael Nicolás Gaggion Zulpo

Core offers access to Nuclear Magnetic Resonance (NMR) spectroscopy studies. Facility houses three solution-state FT-NMR instruments operating at proton frequencies of 400, 500 and 600 MHz, a TD-NMR 20 MHz relaxometer and an EPR spectrometer. UC-NMR Core Facility provides researchers and institutions with expertise, services and tools to carry out research requiring solution Nuclear Magnetic Resonance spectroscopy.

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• 6 months ago - by Anonymous

Core provides histological services in order to facilitate productivity and success of investigators based in the Rangos Research Center and researchers in other units of the University of Pittsburgh and UPMC, as well as clients in other academic institutions in the Pittsburgh area.

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• 6 months ago - submitted by Riley Gedrys

Core offers full histology services including processing and embedding, cutting, staining, and immunohistochemistry. Our services can be customized to fit the needs of any research program.

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• 6 months ago - by Anonymous

Microplate reader designed for academic, clinical, and industrial laboratories to detect light-emitting or absorbing markers with Manufacturer/Brand: PerkinElmer (formerly Wallac Oy). It supports over 10 non-radioactive technologies, including fluorescence, luminescence, time-resolved fluorometry, and absorbance in various plate formats (1-864 wells). Accepts microtitration plates (up to 1536 wells), Petri dishes, slides, and filters.Equipped with shaking, scanning, and optional temperature control/liquid dispensers for kinetic studies. Operates as a stand-alone unit or integrates with robotic systems for high-throughput screening.

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• 6 months ago - by Anonymous

Core to accelerate scientific discovery in G protein-coupled receptors (GPCRs) physiology and pharmacology. Provides services to identify signal transduction processes that are specific to their GPCR of interest (such as opioid, cannabinoid and muscarinic) that is either natively present or expressed heterologously in cell systems. Assists investigators with drug development studies. Support researchers with assay development and optimization, pilot data, and grant assistance. Houses instrumentation used.

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• 6 months ago - by Anonymous

Benchtop instrument designed for life science research, specifically for imaging, detecting, and quantifying protein and nucleic acids on gels and blots. It enables multi-channel analysis, including laser infrared (IR) fluorescence, RGB visible fluorescence, and chemiluminescence, allowing for multiplexed Western blots.

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• 6 months ago - by Anonymous

Software tool for reconstruction of higher order chromatin from scRNA-seq and scATAC-seq. Chromatin compartment inference from single-cell RNA- and ATAC-seq.

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• 6 months ago - by Anonymous

Data resource for clinical transcriptomes with cancer treatment response, and meanwhile supports various data analysis functions, providing insights into the molecular determinants of drug resistance. CTR-DB 2.0 is updated cancer clinical transcriptome resource, expanding primary drug resistance and newly adding acquired resistance datasets and enhancing the discovery and validation of predictive biomarkers.

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• 6 months ago - by Anonymous

Software tools for parsing measurement with threshold over time data (eg tumour treatment studies) and generating interactive and static plots.

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• 6 months ago - by Anonymous

Software pipeline for dissecting glioblastoma risk signatures in the tumor immune microenvironment based on single-cell, bulk, and spatial transcriptomic data.

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• 6 months ago - submitted by Tengyue Li

Software pipeline for identifying enhancers in bulk or single-nucleus ATAC-seq and multiomic data with a high degree of accuracy for prioritizing testing of promising candidate cell type enhancers for targeting homologous cell types across mammalian species.

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• dkNET
• 6 months ago - submitted by Maryann Martone

Core enables generation of genetically defined human iPSC-derived hepatocytes, CRISPR/Cas9 mediated gene editing, and primary mouse hepatocyte isolation.

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• SciCrunch
• 6 months ago - submitted by Edyta Vieth

Software data-centric, backend-agnostic framework for zero-shot cell-type annotation. Data-centric marker distillation for zero-shot cell-type and spatial annotation with LLMs.

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• 6 months ago - by Anonymous

Software Python library for spatial analysis of histological brain section images using a reference brain atlas. Implements the core quantification algorithms from the QUINT workflow, designed to replicate and extend the Quantifier feature of the Nutil software.

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• 6 months ago - by Anonymous

Software tool is revision of classic ilastik. Used for interactive (supervised) pixel-level image classification and segmentation.

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• 6 months ago - by Anonymous