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Open platform for interoperable life science experimental metadata. Metadata framework as set of community specifications and software tools for enabling discovery, exchange and publication of metadata from experiments in life sciences. Python library for creation, editing, parsing, and validating of ISA-Tab and ISA-JSON formats.Provides programmatic metadata handling functionality to support automation, common interface and interoperable medium between two ISA formats, as well as with other life science data formats required for depositing data in public databases.
Web tool for 3D data annotation for connectomics.Open source tool for annotating and exploring large 3D image datasets. Web based data sharing, annotation and visualization software for large scale 3D images. Provides flight mode, single view egocentric reconstruction method enabling to reconstruct for axons and for dendrites in 3D electron microscopic data from mammalian cortex. Supports skeleton and volumetric annotations as well as data management functionality.
Incorporated as non-profit member based organization promoting scientfic collaboration in computational neuroscience.Advances computational neuroscience by pushing limits of large scale simulations of biologically realistic neuronal networks.
Software tool as feature selection method based on nearest neighbors for single-cell data.
Software tool as novel deep learning approach for multi-stage malaria parasites recognition in blood smear images using deep transfer graph convolutional network. DTGCN model is based on unsupervised learning by transferring knowledge learnt from source images that contain discriminative morphology characteristics of multi stage malaria parasites.
Not-for-profit medical research facility located at and partnering with the City of Hope National Medical Center in Duarte, CA, United States.Fields of research include Cancer, Diabetes, Metabolic disorder, HIV/AIDS.
Department of Pathology at City of Hope combines state-of-the-art laboratories equipped with the latest diagnostic techniques and advanced instrumentation with superior investigative skills to accurately and rapidly identify even the rarest and most complex diseases. Our experts provide comprehensive services, from initial diagnosis to monitoring of prognostic indicators throughout the treatment process.
Core light microscopy facility located on main campus of Clemson University. Offers access to multiple Leica Microsystems instruments, including SP8X LIGHTNING confocal with STED,SPE confocal, DMi8 widefield/TIRF/GSD system,THUNDER model organism imager, LMD6500, M125 stereoscope, and DM750P polarized light microscope.We also house Olympus LEXT OLS4100 optical profiler, GE InCell 2500HS high content screener, and Biorad S3e cell sorter. Offers assistance with equipment selection, image analysis, and sample preparation. Offers prepared slides for 4 color fluorescence imaging and can also prepare custom slides.
Software R package to perform differential transcript usage analysis of bulk or single-cell RNA-seq data.
GFAP is a major protein of the nervous system localized in astrocytes, large non-neuronal cells which forms part of the blood brain barrier. It is also found in neural stem cells. Antibodies to GFAP are therefore used to identify astrocytes and monitor neural development. Recent work has shown that GFAP leaks into blood, cerebrospinal and other fluids following a variety of damage and disease states. Accordingly sensitive ELISA, MSD, Luminex and Simoa based assays have been developed and are widely utilized in research and clinical contexts. This recombinant human GFAP is an ideal protein standard for such assays.
Human neurofilament light chain (NF-L) is a major neuron specific protein of perikarya and especially in large projection axons . Accordingly antibodies to NF-L are useful to identify neuronal cells and their axonal processes. In addition release of NF-L into blood, cerebrospinal and other fluids reveals ongoing axonal and neuronal loss. This loss may provide useful prognostic and diagnostic information. Sensitive assays for NF-L have therefore been developed. This recombinant human NF-L protein can and has been widely employed as a protein standard for NF-L ELISA, MSD, Luminex, Simoa and other antibody based assays.
Laser scanning digital microscope for non-contact 3D observations and measurements of surface features at 10 nanometer resolutions with fast image acquisition and high-resolution images over wider area. Z-drive moves in steps less than 1nm, accuracy and repeatability guaranteed by Olympus. The system includes 5 objectives: 5x/0.15, 10x/0.30, 20x/0.60, 50x/0.95, and 100x/0.95.
Central core facility open to members of all faculties and the university clinic. Consists of 14 rooms in the Center for Integrative Signalling Analysis with 9 microscopy rooms with 20 microscope set-ups (3D-STED, confocal FLIM, two 2-photon confocal microscopes, 4 conventional confocal microscopes, lightsheet microscope, 4 high-end widefield ratio-imaging set-ups, 4 fluorescence stereo microscopes, 3 special set-ups for screening. LIC microscopes are hosted in Biosafety level S2 and S1 environments, connected to a large wet lab area and a cell culture room, both Biosafety level S2 classified. Additionally, the LIC offers a large computer lab with 12 high-end workstations for image processing and analysis. The LIC also covers two additional rooms, hosting 3 LSM systems in a neighboring building of the Signalling Campus Freiburg (SCF).
Open access light microscopy facility of College of Life Sciences. Offers wide range of confocal and conventional fluorescence microscopes and image analysis resources. AIF is part of Core Biotechnology Services CBS.
Software package for quantitative analysis of fluorescence microscopy and spectroscopy data, with focus on experiments using pulsed interleaved excitation. Open source software package written in MATLAB that offers workflow through its graphical user interface. Framework for integrated analysis of imaging, single-molecule, and ensemble fluorescence data.Supports most types of data collection modalities.
Software R package for mapping quantitative trait loci with high dimensional data and multiparent populations. Used for analysis of high dimensional data and complex crosses. Interactive software environment for mapping quantitative trait loci in experimental populations.R/qtl2 software expands scope of R/qtl software package to include multiparent populations derived from more than two founder strains, such as Collaborative Cross and Diversity Outbred mice, heterogeneous stocks, and MAGIC plant populations.
Software R package to perform differential gene correlation analysis. Performs differential correlation analysis on input matrices, with multiple conditions specified by design matrix.
Software suite of tools for reconstructing genomes using RNA-Seq data from multiparent population and for quantifying allele specific expression.
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Collection of very large scale electron microscopy datasets available for on-line browsing. Large scale electron microscopy datasets.