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Web service provides functional annotation of cell types within the lung and combines functional and single cell data for a rigorous catalogue of cell lineages.
Software Python package to study microbial communities using metabolic modeling. Metagenome-scale modeling to infer metabolic interactions in the gut microbiota.
Software tool to analyse interactions in microbial communities. Species metabolic interaction analysis (SMETANA) of microbial communities.
Software extended tools for correlation analysis and visualization.
120 kV Transmission Electron Microscope (TEM) designed for high-contrast, high-resolution imaging in biological and materials science, often operated in, lighted rooms. It features a proprietary dual-mode objective lens for switching between wide-field and high-resolution views, along with automated, user-friendly software for navigation and image acquisition.
Imaging system used in laboratories for chemiluminescence and fluorescence imaging, specifically for detecting and analyzing protein bands (Western blot), DNA/RNA gels, and RGB fluorescence. It features a cooled CCD camera for detecting low-abundance samples.
Upright microscope designed for histology and pathology. With motorized z-focus, motorized and coded 7x nosepiece, fully automated transmitted light axis, and fully automated 5x or 8x fluorescence axis, the automated Leica DM6000 B research microscope provides all transmitted light contrast methods including the world’s first fully automated Differential Interference Contrast (DIC).
Software R package for assessment of PCR artifacts in RNA-Seq data. Used for duplication rate quality control for RNA-Seq datasets.
Software open-source Python library providing graphical user interface for visualization and manual curation of large-scale electrophysiological data. It is optimized for high-density multielectrode arrays containing hundreds to thousands of recording sites.
Specialized, compact, all-in-one fiber photometry system designed to monitor neural activity or neurotransmitter levels in freely moving animals. By combining multiple built-in LEDs (405-440 nm, 460-490 nm, etc.) and photodetectors, it enables simultaneous, multi-wavelength measurement of calcium indicators (e.g., GCaMP) and red fluorophores alongside isosbestic controls to correct for movement artifacts.
Specialized, high-performance power supplies and controllers designed for neuroscience research, specifically to drive Connectorized LEDs and fiber-coupled light sources. They offer 1, 2, or 4 independent channels for controlling light intensity, modulation (CW, TTL, analog), and complex, software-defined, or automated pulse sequences required for optogenetics and photometry experiments.
FPGA-based data acquisition unit designed for real-time monitoring of neural activity in behaving animals. It synchronizes excitation light sources (LED drivers) with detection (photodetectors) to record fluorescence signals, typically using lock-in amplification to filter noise and separate multiple wavelengths (e.g., ).
Core provides immunopathological services from sample embedding and staining to microscopic evaluation. Full service for histopathology includes tissue embedding, staining of tissue sections and microscopic analysis: preparation of paraffin blocks,cutting of cryo and paraffin sections,histochemistry,immunohistochemistry/-fluorescence/multiplexing, in-situ hybridization,Scoring/quantification,storage.
Software tool for calling copy number variants (CNVs) from human DNA sequencing data. It can work either with germline data, or paired tumor/normal samples. Its primary input is aligned reads (in .bam format), and its primary output is a report (in a .vcf file) giving the copy number status of the genome.
Core provides comprehensive proteomic analyses using LC-MS platforms, supporting post-translational modifications, protein-protein interactions, spatial proteomics, and single-cell workflows with bioinformatics.
Mayo Clinic's Biomedical Imaging Resource Core in Rochester, Minnesota, focuses on supporting and advancing research in biomedical imaging and visualization sciences. Provides guidance on protocol design, routine image analysis, and custom software and hardware solutions. Also, media and model production resources are available to investigators for the creation of high-quality visualizations and physical models of research data.Core provides services to all Mayo Clinic faculty and staff engaged in research. Also, services may be available on a limited basis to investigators and research collaborators outside Mayo Clinic. Before scheduling, contact the core to design optimal settings for the specified imaging task.
Core generates transgenic and gene-targeted mice for researchers at Mayo Clinic's campuses in Arizona, Florida and Minnesota to enable researchers to observe how genes, or mutant variations of genes, are expressed. Provides services to all Mayo Clinic faculty and staff engaged in research. Also, services are offered to non-Mayo investigators and research collaborators.
Web-based platform for flexible and reproducible neuroimaging meta-analysis. Enables to create customized, reproducible neuroimaging meta-analyses with no code/low code solutions. It integrates a regularly updated centralized literature database (NeuroStore) with tools for systematic study curation and annotation following PRISMA guidelines, allowing users to search across tens of thousands of indexed fMRI studies or import external study lists. Analyses can be executed locally or in the cloud using the NiMARE Python library, and results can be interactively reviewed, shared, and archived, facilitating transparent meta-analyses and collaborative knowledge building.
Core provides comprehensive services for generation of viral particles from existing vectors or newly created vectors.
Software quality-assurance layer for pathway enrichment interpretation that converts enrichment term lists into context-conditioned, evidence-linked, schema-bounded claims and assigns PASS/ABSTAIN/FAIL via predefined, rule-based audit gates (stability, context validity stress tests, evidence-link integrity, and contradiction checks), producing decision-grade reports with audit logs. The LLM is confined to proposal-only steps; final decisions are mechanical and reproducible.