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Molecular Pharmacology and Chemical Biology Shared Resource (MPCBSR) provides services for the assessment of new therapeutics, including clinical trial specimens and determination of clinical PK/PD and potential drug-drug interactions (DDI), pharmacological studies on novel therapeutics in preclinical models, including DM/PK/PD, on-target mechanisms, biomarkers, and combination effects, and chemical synthesis of new compounds and drug delivery nanomaterials for improved therapy.

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• SciCrunch
• 10 months ago - submitted by Edyta Vieth

Purpose of the Myc Hubsite The emergence of complex DNA microarray data on gene expression creates vast new opportunities but also poses serious challenges for information and library sciences. This complexity becomes more challenging as certain genes, such as MYC that encodes a transcription factor, switch on other genes. The purpose of this website is to provide a hub for the integration of information on Myc target genes, the role of Myc in human cancers, and proteins that interact with the Myc transcription factors. Links are provided that connect to PUBMED citations, Unigene database, and in specific cases to original data. Sponsor: Funded by a grant from the National Library of Medicine

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• SciCrunch
• 17 years ago - by Anonymous

The United States federal government Department of Education, which oversees policies on federal financial aid for education, collecting data and disseminating research, and working to promote key educational discussions and equal access to education.

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• SciCrunch
• 16 years ago - submitted by Andrea Stagg

Core provides histological services in order to facilitate productivity and success of investigators based in the Rangos Research Center and researchers in other units of the University of Pittsburgh and UPMC, as well as clients in other academic institutions in the Pittsburgh area.

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• RRID
• 9 months ago - submitted by Riley Gedrys

THIS RESOURCE IS NO LONGER IN SERVICE. Documented August 23, 2017.

Annotated database of fluorescence microscope images depicting subcellular location proteins with two interfaces: a text and image content search interface, and a graphical interface for exploring location patterns grouped into Subcellular Location Trees. The annotations in PSLID provide a description of sample preparation and fluorescence microscope imaging.

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• SciCrunch
• 17 years ago - by Anonymous

Commissioned Corps of the United States Public Health Service, is the federal uniformed service of the U.S. Public Health Service, and is one of the eight uniformed services of the United States.

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• SciCrunch
• 17 years ago - submitted by Andrea Stagg

Core provides immunopathological services from sample embedding and staining to microscopic evaluation. Full service for histopathology includes tissue embedding, staining of tissue sections and microscopic analysis: preparation of paraffin blocks,cutting of cryo and paraffin sections,histochemistry,immunohistochemistry/-fluorescence/multiplexing, in-situ hybridization,Scoring/quantification,storage.

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• RRID
• 9 months ago - submitted by Edyta Vieth

Non profit organization and informational portal directed towards patients and families. AFA is an umbrella orgnization uniting over 1600 member organizations to collaborate on education, resources, best practices and advocacy. AFA provides several grant opportunities for AFA's nonprofit member organizations and to individuals in need.

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• SciCrunch
• 16 years ago - by Anonymous

The Danish Multiple Sclerosis Center (DMSC) comprises the MS Clinic and the MS Research Unit including the Neuroimmunology Laboratory. The main research areas are: clinical research including investigator driven trials of new therapies in MS, neuroimaging, neuropsychology and rehabilitation; pathogenesis of MS with focus on immunology, biomarkers and treatment response; as well as studies in the pathology and genetics of MS. DMSC is part of the Department of Neurology, Rigshospitalet, and the Faculty of Medicine, University of Copenhagen. The research facilities are located in sections 6311 and 9392 at the hospital site. DMSC constitutes one of the European MS Centers of Excellence and has extensive collaboration with institutions in Denmark, in other European countries, as well as overseas. DMSC is supported by both national and international grants.

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• SciCrunch
• 16 years ago - by Anonymous

Software application for de novo identification and extraction of differentially methylated regions (DMRs) from the human genome using Whole Genome Bisulfite Sequencing (WGBS) and Illumina Infinium Array (450K and EPIC) data. Provides functionality for filtering probes possibly confounded by SNPs and cross-hybridisation. Includes GRanges generation and plotting functions.

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• RRID
• 9 months ago - by Anonymous

An endowment that offers funding for memory research. The McKnight Endowment Fund for Neuroscience is an independent charitable organization established by The McKnight Foundation to carry out the wishes of its founder, William L. McKnight (1887-1979). Currently, the Endowment Fund for Neuroscience administers four awards which support young and established neuroscientists and encourage interdisciplinary collaboration: * Memory and Cognitive Disorders Awards * Neuroscience of Brain Disorders Awards * Scholar Awards * Technological Innovations in Neuroscience Awards Mr. McKnight, who led the 3M company for three decades, had a personal interest in memory and its diseases. He chose to set aside part of his legacy to bring hope to those suffering from brain injury or disease and cognitive impairment.

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• SciCrunch
• 15 years ago - by Anonymous

One of the largest financiers of research in Sweden that promotes scientific research, teaching and/or education beneficial to the Kingdom of Sweden. 20-30 percent of the Foundation''s grants relate to high-value research equipment for use within the technical, natural sciences and biomedical fields, and about 50 percent relate to major research projects and substantial scientific networks. Universities, academies and similar research and educational institutions are eligible for grants within the following fields: * Expensive scientific equipment * Fellowship programs initiated by the Foundation * Selected research projects of significant potential * Larger educational research projects Applications may be submitted by individual scientists, or research groups affiliated to a Swedish university or equivalent institution. An application may also be submitted by the management of a university, university college, scientific academy, or national research associations. Applications from private individuals without connection to a scientific institution are not considered.

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• SciCrunch
• 16 years ago - by Anonymous

Private university in Chicago, Illinois, United States. Founded in 1972, it is the academic arm of Rush University Medical Center.

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• RRID
• 8 months ago - submitted by Edyta Vieth

The mission of the Spinal Muscular Atrophy Foundation is to accelerate the development of a treatment for SMA, the number one genetic killer of infants and toddlers. To help speed the realization of a treatment or cure, the SMA Foundation is committed to: Developing private sector involvement in SMA drug development by fostering alliances between academia, government, and pharmaceutical and biotechnology companies Increasing government funding and support through targeted efforts to increase Congressional and NIH awareness Raising awareness of SMA among government leaders, members of the pharmaceutical and biotechnology industries, and the public at large

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• SciCrunch
• 16 years ago - by Anonymous

The National Institute of Advanced Industrial Science and Technology (AIST), led by President Nomakuchi, is a public research institution funded by the Japanese government to a large extent. The present AIST is a rather new research organization established in 2001. However, AIST and its predecessor organizations have been contributing to society through continuous advancement in technologies and support of Japanese industries since 1882. Headquarters of AIST are located in Tsukuba and Tokyo. AIST has over 40 autonomous research units in various innovative research fields, and the units are located at nine research bases and several sites (smaller than research bases) of AIST all over Japan. About 2400 researchers (about 2100 with tenure: about 80 from abroad) and thousands of visiting scientists, post-doctoral fellows, and students from home and abroad are working at AIST. About 700 permanent administrative personnel and many temporary staff support research works of AIST.

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• SciCrunch
• 13 years ago - submitted by Andrea Stagg

Software R package for conducting quantile regression analysis, which estimates relationship between variables across various points (quantiles) in distribution, rather than just average. Used to analyze non-normal data, handle outliers, and model extreme outcomes, such as 90th percentile. Used for conditional quantile functions: Linear and nonlinear parametric and non-parametric (total variation penalized) models for conditional quantiles of univariate response and several methods for handling censored survival data. Portfolio selection methods based on expected shortfall risk are also now included.

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• RRID
• 8 months ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE, documented on Septemeber 02, 2014. Through a collaborative effort with experts in doctor-elderly patient interaction who participated in the development of ADEPT, a database of approximately 435 audio and video tapes of visits of patients age 65 and older (n=46) to their primary physician was established for testing ADEPT and for access by medical educators and researchers. Data associated with each tape include reason for visit, physician characteristics (age, race, gender), patient characteristics (age, race, gender), companion characteristics (age, race, gender), and length of doctor-patient relationship. Through a collaborative effort with experts in doctor-elderly patient interaction who participated in the development of ADEPT, a database of approximately 435 audio and video tapes of visits of patients age 65 and older (n=46) to their primary physician was established for testing ADEPT and for access by medical educators and researchers. Data associated with each tape include reason for visit, physician characteristics (age, race, gender), patient characteristics (age, race, gender), companion characteristics (age, race, gender), and length of doctor-patient relationship. Patient visits to their primary physician were videotaped at four sites: an academic medical center in the Midwest, an academic medical center in the Southwest, a suburban managed care medical group, and an urban group of physicians in independent practice. Repeat visits between the same doctor and patient were taped for 19 patients resulting in 48 tapes of multiple visits. Patients were recruited in the waiting room for a convenience sample. Before the visit, patients provided demographic data and completed a global satisfaction form. Following the visit, patients completed the SF-36, and the ABIM for patient satisfaction. Two weeks following the visit, patients were contacted by telephone and asked about their understanding, compliance and their utilization of health services over the past year. At twelve months, patients were contacted by telephone for administration of the SF-36, the global satisfaction form, and the utilization of health services survey. Data Availability: Archived at the Saint Louis University School of Medicine Library. Interested researchers and medical educators should contact the PI, Mary Ann Cook, JVCRadiology (at) sbcglobal.net * Dates of Study: 1998-2001 * Study Features: Longitudinal, Anthropometric Measures * Sample Size: 46

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• SciCrunch
• 15 years ago - by Anonymous

Research charity based in London, in the United Kingdom. It was established in 1936 with legacies from the pharmaceutical magnate Henry Wellcome to fund research to improve human and animal health.

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• SciCrunch
• 16 years ago - submitted by Stephen Larson

Web-based resource for preserving and sharing pharmacokinetic data generated through preclinical and clinical HIV research.

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• RRID
• 8 months ago - submitted by Anita Bandrowski

A longitudinal, epidemiologic study to identify the common risk factors or characteristics that contribute to cardiovascular disease by following its development over a long period of time in a large group of participants who had not yet developed overt symptoms or suffered a heart attack or stroke. Since that time the FHS has studied three generations of participants resulting in biological specimens and data from nearly 15,000 participants. Since 1994, two groups from minority populations, including related individuals have been added to the FHS. FHS welcomes proposals from outside investigators for data and biospecimens. The researchers recruited 5,209 men and women between the ages of 30 and 62 from the town of Framingham, Massachusetts, and began the first round of extensive physical examinations and lifestyle interviews that they would later analyze for common patterns related to CVD development. Since 1948, the subjects have continued to return to the study every two years for a detailed medical history, physical examination, and laboratory tests, and in 1971, the Study enrolled a second generation - 5,124 of the original participants'''' adult children and their spouses - to participate in similar examinations. In 1994, the need to establish a new study reflecting a more diverse community of Framingham was recognized, and the first Omni cohort of the Framingham Heart Study was enrolled. In April 2002 the Study entered a new phase, the enrollment of a third generation of participants, the grandchildren of the Original Cohort. In 2003, a second group of Omni participants was enrolled. Over the years, careful monitoring of the Framingham Study population has led to the identification of major CVD risk factors, as well as valuable information on the effects of these factors such as blood pressure, blood triglyceride and cholesterol levels, age, gender, and psychosocial issues. Risk factors for other physiological conditions such as dementia have been and continue to be investigated. In addition, the relationships between physical traits and genetic patterns are being studied. FHS clinical and research data is stored in the dbGaP and NHLBI Repository repositories and may be accessed by application. Please check the following repositories before applying for data through FHS. Investigators seeking data that is not available through dbGaP or BioLINCC or seeking biological specimens may submit a proposal through the FHS web-based research application. The FHS data repository may be accessed through this FHS website, under the For Researchers link, then Description of Data, in order to determine if and how the desired data is stored. Proposals may involve the use of existing data, the collection of new data, either directly from participants or from previously collected samples, images, or other materials (e.g., medical records). The FHS Repository also has biological specimens available for genetic and non-genetic research proposals. Specimens include urine, blood and blood products, as well as DNA.

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• SciCrunch
• 14 years ago - by Anonymous