Curator Dashboard

Community led catalog of extensions to Neurodata Without Borders data standard.

• Resource
• SciCrunch
• 5 years ago - submitted by Oliver Ruebel

Rabbit monoclonal [EPR10643(2)] to TMEM16A produced by abcam

• Resource
• SciCrunch
• 5 years ago - submitted by Tyler Rodriguez

Software tool for porosity analysis of tree slice. Used for 3D image analysis, density analysis, 3D distances and angles, thickness and separation, automated batch analysis.

• Resource
• RRID-Legacy
• 5 years ago - by Anonymous

The IGFs are mitogenic, polypeptide growth factors that stimulate the proliferation and survival of various cell types, including muscle, bone, and cartilage tissue in vitro. IGFs are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times. The IGFs belong to the Insulin gene family, which also contains insulin and relaxin. The IGFs are similar to insulin by structure and function, but have a much higher growth-promoting activity than insulin. IGF-II expression is influenced by placenta lactogen, while IGF-I expression is regulated by growth hormone. Both IGF-I and IGF-II signal through the tyrosine kinase type I receptor (IGF-IR), but IGF-II can also signal through the IGF-II/Mannose-6-phosphate receptor. Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptide regions. Recombinant Human IGF-I and IGF-II are globular proteins containing 70 and 67 amino acids, respectively, and 3 intra-molecular disulfide bonds. The calculated molecular weight of Recombinant Human IGF-II is 7.5 kDa.

• Resource
• RRID-Legacy
• 5 years ago - submitted by Ki-Sun Park

This assay employs an antibody specific for mouse IGF2 coated on a 96-well plate. Standards and samples are pipetted into the wells and IGF2 present in a sample is bound to the wells by the immobilized antibody. The wells are washed and biotinylated anti-mouse IGF2 antibody is added. After washing away unbound biotinylated antibody, HRP-conjugated streptavidin is pipetted to the wells. The wells are again washed, a TMB substrate solution is added to the wells and color develops in proportion to the amount of IGF2 bound. The Stop Solution changes the color from blue to yellow, and the intensity of the color is measured at 450 nm.

• Resource
• RRID-Legacy
• 5 years ago - submitted by Ki-Sun Park

PD98059 is supplied as a lyophilized powder. For a 20 mM stock, reconstitute 1.5 mg in 280 μl anhydrous DMSO (5 mg in 933.3 μl anhydrous DMSO). For 50 mM stock, reconstitute 1.5 mg in 112 μl anhydrous DMSO (5 mg in 373.3 μl). Working concentrations and length of treatment can vary depending on the desired effect, but it is typically used as a pretreatment at 5 - 50 μM for one hour prior to treating with a stimulator.

• Resource
• RRID-Legacy
• 5 years ago - submitted by Ki-Sun Park

BMS-754807 is an orally bioavailable antagonist of human insulin-like growth factor type I receptor (IGF-1R) with potential antineoplastic activity. BMS-7548077 binds to IGF-1R, preventing IGF-1 ligand binding and activation of IGF-1R-mediated signaling pathways; inhibition of IGF-1R-mediated signaling pathways may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. IGF-1R is a receptor tyrosine kinase expressed on most tumor cells and is involved in mitogenesis, angiogenesis, and tumor cell survival

• Resource
• RRID-Legacy
• 5 years ago - submitted by Ki-Sun Park

RNAscope® 2.5 HD Detection Reagents-RED assay are designed for RNA in situ hybridization (ISH) based on ACD's patented signal amplification and background suppression technology. This manual assay is a single-plex, chromogenic-RED assay. The detection reagents contains AMP 1, APM2, AMP 3, AMP 4, AMP 5, AMP 6, Fast RED-A, Fast RED-B. The detection reagents provide enough reagents to stain ~20 tissue sections, each with an area of approximately 20 mm x 20 mm (0.75in x 0.75in).To run the detection reagents you will need the pretreatment kit and the wash buffer reagents.Disclaimer: Photos 2.5 products will be updated shortly.

• Resource
• RRID-Legacy
• 5 years ago - submitted by Ki-Sun Park

RNAscope® 2.5 HD Assay- BROWN,RNAscope® 2.5 HD Assay- RED,RNAscope® 2.5 HD Duplex Assay,RNAscope® Multiplex Fluorescent Assay

• Resource
• RRID-Legacy
• 5 years ago - submitted by Ki-Sun Park

Canadian, public interest, open science company with mission of characterizing commercially available antibody reagents for every human protein. Antibody characterization methodology and dataset. Gold standard genetic characterization process uses both cell line expressing adequate endogenous levels of target protein and CRISPR knockout version of same cell line as negative control. Antibody characterization methodology follows seminal methodology formalized at Montreal Neurological Institute.

• Resource
• RRID-Legacy
• 5 years ago - submitted by Anita Bandrowski

Comprehensive collection of high quality microbial genomics reference data for bacteria, viruses, and fungi in holdings of American Type Culture Collection.

• Resource
• RRID-Legacy
• 5 years ago - submitted by Jonathan Jacobs

Software tool as NCBI prokaryotic genome annotation pipeline. Used to annotate both complete genomes and draft genomes comprising multiple contigs. Integrated into NCBI infrastructure and processes, and uses modular software framework, GPipe, developed at NCBI for execution of all annotation tasks, from fetching of raw and curated data from public repositories through sequence alignment and model based gene prediction, to submission of annotated genomic data to public NCBI databases.

• Resource
• RRID-Legacy
• 5 years ago - by Anonymous

Software R package that provides classes and methods for spatial data.

• Resource
• RRID-Legacy
• 5 years ago - by Anonymous

Software R package to identify cells with active gene sets in single cell RNA-seq data. Used for analysis of gene set activity in single cell RNA-seq data.Used to calculate whether critical subset of input gene set is enriched within expressed genes for each cell.

• Resource
• RRID-Legacy
• 5 years ago - by Anonymous

Analyst module for statistical analysis and interactive visualization of complex data such as genotype, phenotype, and omics data. Provides data mining solution that can be integrated into existing research IT environments with rich set of APIs. Supports integration of R scripts.

• Resource
• RRID-Legacy
• 5 years ago - by Anonymous

Software R package for interfacing with genome browsers.Supports integration of existing genome browsers with experimental data analyses performed in R. R interface to genome annotation files and UCSC genome browser.

• Resource
• RRID-Legacy
• 5 years ago - by Anonymous

Open source software R package for interacting with common Bioconductor classes Ranges and GenomicRanges. Grammar of genomic data transformation. Provides grammatical and consistent way of manipulating these classes to increase accessiblity for new Bioconductor users.

• Resource
• RRID-Legacy
• 5 years ago - by Anonymous

Software tool as ChIP-seq pipeline for processing ChIP-seq reads, aligning to reference genome, peak calling, and IDR analysis of replicate data according to ENCODE standards.

• Resource
• RRID-Legacy
• 5 years ago - by Anonymous

Software package to retrieve nearest genes around peak, annotate genomic region of peak, implements statstical methods for estimate significance of overlap among ChIP peak data sets, and incorporate GEO database for user to compare own dataset with those deposited in database.Several visualization functions are implemented to summarize coverage of peak experiment, average profile and heatmap of peaks binding to TSS regions, genomic annotation, distance to TSS, and overlap of peaks or genes.

• Resource
• RRID-Legacy
• 5 years ago - by Anonymous

Provides access to high parameter cell analysis and sorting instrumentation along with scientific expertise.Services provided include Cell Sorting,FACS Cell Sorting,Flow Cytometric Analysis,Multi-color Flow Cytometry,Spectral Flow Cytometry.

• Resource
• SciCrunch
• 5 years ago - submitted by Edyta Vieth