Curator Dashboard

Core focused on systems genetics approach to understanding diseases, development, aging, and fertility in mouse. Projects range from development of new community resources, such as Collaborative Cross, to development of tools and assays for measuring genetic diversity and discerning genomic structure. Collaborative Cross is reference population for mapping multigenic traits that would be free of population structure and it is new panel of recombinant inbred lines generated by randomizing genetic diversity of existing inbred mouse resources.

• Resource
• SciCrunch
• 9 years ago - submitted by Mason Pairish

Multifunction phosphoimager fluorimager laser scanner that collects fluorescent or storage phosphor images from gels, membranes and phosphor screens. It is equipped with blue (450 nm) and red (635 nm) lasers, can scan at resolutions down to 50 microns. It is able to quantify radioactive gels for commonly used isotopes such as 32P, 33P, 125I, 35S, and 14C. There are three detection modes: phosphor screen mode, red/blue fluorescence, chemifluorescence.

• Resource
• SciCrunch
• 7 years ago - submitted by Edyta Vieth

An integrated resource to analyze signaling pathway cross-talks, transcription factors, miRNAs and regulatory enzymes. The multi-layered database structure is made up of signaling pathways, their pathway regulators (e.g., scaffold and endocytotic proteins) and modifier enzymes (e.g., phosphatases, ubiquitin ligases), as well as transcriptional and post-transcriptional regulators of all of these components. The website allows the interactive exploration of how each signaling protein is regulated. Features * experimental data not only from humans but from two invertebrate model organisms, C. elegans and D. melanogaster; * combines manual curation with large-scale datasets; * provides confidence scores for each interaction; * operates a customizable download page with multiple file formats (e.g., BioPAX, Cytoscape, SBML).

• Resource
• SciCrunch
• 13 years ago - by Anonymous

R24 OD018250 We are developing an in-depth, easily accessible annotation of the dog genome to support disease research. The domestic dog is an important model for a wide variety of human diseases, including cancer, inflammatory disease, cardiovascular diseases and neurological and behavioral traits. We are using RNA-Seq to generate a more complete gene set and ChIP-seq to map histone marks implicating different regulatory states in different tissues. We are integrating this new data with available SNP data sets, published association signals, and other existing genome annotations to generate a resource easily accessible to the research community. The annotation will be served on the CanFam3.1 genome using the UCSC browser through a Track Hub that we build and manage.

• Resource
• SciCrunch
• 8 years ago - submitted by Isabella Froman

Purdue Translational Pharmacology (PTP) facility provides in vivo pharmacological evaluation using porcine models. The facility is situated in the Purdue University School of Veterinary Medicine complex, which provides constant care and monitoring of the animals. The PTP uses unique penning systems to automate blood sampling and maintain a humane and stress free environment for test subjects. The PTP synergizes with the Metabolite Profiling Facility in the Bindley Bioscience Center, which facilitates the pharmacological analysis of blood samples collected.

• Resource
• SciCrunch
• 14 years ago - by Anonymous

A measure for the assessment of episodic memory that involves recalling increasingly lengthy series of illustrated objects and activities that are presented in a particular order on the computer screen. The participants are asked to recall the sequence of pictures that is demonstrated over two learning trials; sequence length varies from 6-18 pictures, depending on age. Participants are given credit for each adjacent pair of pictures (i.e., if pictures in locations 7 and 8 and placed in that order and adjacent to each other anywhere such as slots 1 and 2 one point is awarded) they correctly place, up to the maximum value for the sequence, which is one less than the sequence length (if there are 18 pictures in the sequence, the maximum score is 17, because that is the number of adjacent pairs of pictures that exist). The test takes approximately 7 minutes to administer. This test is recommended for ages 3-85.

• Resource
• SciCrunch
• 13 years ago - by Anonymous

An international not-for-profit organization to solve problems in agriculture and the environment. Specialize in microbial identification and verification, and provide professional microbiology services in support of industry, academia and agriculture. Established by a United Nations.

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• SciCrunch
• 8 years ago - submitted by Anita Bandrowski

UCD Mouse Biology Program (MBP) is a coordinated, campus-supported teaching, research, and service resource of infrastructure and fundamental expertise directed at developing, promoting, and enhancing the use of mouse model systems for understanding and resolving biological problems. Established in 1997, the goal of the MBP is to meet the needs of investigators utilizing genetically-altered mice for basic, clinical, and translational research. The mission of the MBP is to strive for excellence by focusing on hypothesis-driven research that advances health, well-being, and performance, and to educate and train the next generation of faculty, residents, graduate students, and veterinary students in the application of genetically-altered mice.

• Resource
• SciCrunch
• 14 years ago - by Anonymous

Assessment test that is a measure of gaze stability, which helps identify individuals who may have a deficit of the vestibular system (which regulates internal balance). The NIH Toolbox Visual Acuity Test must be administered followed by the DVA Test. Participants are seated 12.5 feet from a computer monitor at eye level. For the DVA Test, participants wear lightweight headgear that contains a rate sensor, and are asked to move the head back and forth, as if saying no. Once the head is measured to be moving at greater than 180 degrees per second, an optotype flashes on the monitor, and the participant is asked to identify it. Smaller optotypes are displayed as the participant correctly identifies letters, and larger ones are displayed if the participant cannot correctly identify the letter shown, until the computer has calculated the smallest size that the participant can see with the head moving. This is calculated separately for head rotation leftward and rightward from center (though the participant continues shaking the head both ways), and this performance is compared to the participant's visual acuity when the head was stationary (the NIH Toolbox Visual Acuity Test score, sometimes referred to as static visual acuity in the context of the DVA test). The difference between static and dynamic visual acuity represents the vestibular contribution to gaze stability. The DVA Test takes approximately six minutes to administer and is recommended for ages 3-85.

• Resource
• SciCrunch
• 13 years ago - by Anonymous

Software to process cryo-EM images of macromolecular complexes and obtain high-resolution 3D reconstructions from them.

• Resource
• SciCrunch
• 8 years ago - submitted by Richard Posert

Core facility aides ISU investigators in the areas of molecular genetics, microbiology, developmental biology, physiology, anatomy, neurobiology, molecular evolution and systematics, phylogenetics, population genetics, bioinformatics, comparative and computational genetics, and pharmaceutical sciences. In addition the MRCF also serves the DNA sequencing and genotyping needs of an increasing number of investigators at other institutions throughout the state and the nation. Routine activities in the MRCF include automated DNA sequencing and microsatellite analysis (Genotyping), PCR, electrophoresis, and gel documentation and analysis.

• Resource
• SciCrunch
• 14 years ago - by Anonymous

Consortium to identify, fund and support breakthrough technologies that will significantly enhance biopharmaceutical R&D productivity and accelerate the development of new safe and efficacious drugs. CQDM is a neutral ground that brings patient groups, academia, governments, biotech and the pharma industry together to work collaboratively on complex medical challenges. Projects supported by the consortium are highly relevant to the pharmaceutical sector and typically address: * Opportunity for new therapeutic approaches and research * Safe and effective new drug development * Enhancing the efficacy of already existing drugs * Reducing costs, time and risks associated with the discovery and development of new drugs Funded projects typically involve multidisciplinary collaborations between research teams that represent both the academic and the private sector, who are mentored by industry scientists provided by the consortium sponsors.

• Organization
• Consortia-pedia, a FasterCures Project
• 13 years ago - by Anonymous

Software package for simulation framework and codes for estimating nonparametric Granger causality. Used to study brain functions.

• Resource
• RRID-Legacy
• 8 years ago - by Anonymous

Core provides flow cytometry analyzers and cell sorters, with specialty in image-based flow cytometry and cell sorting.Services include unassisted and full-service cell sorting, training on theory and on instruments, consultation on experiment design, protocol development, data analysis, manuscript preparation and grant submission. Applications include image-based analysis powered by machine learning on the Amnis ImageStream; image-based cell sorting using the BD BACS Discover S8; cell sorting for a variety of applications including multi-color sort for bulk culture, indexed cell sort into 96-well plates, cell cycle phase sort and primary tissue sorting for RNA or DNA analysis.

• Resource
• SciCrunch
• 2 years ago - submitted by Edyta Vieth

An independent, non-profit and non-political student exchange organization that provides students in technical degrees (primarily Science, Engineering and the applied arts) with paid, course-related, training abroad and employers with highly skilled, highly motivated trainees, for long or short term projects.

• Resource
• SciCrunch
• 13 years ago - by Anonymous

Portal for randomized controlled trial to compare effectiveness of bariatric surgery versus continuous positive airway pressure (CPAP) therapy for obstructive sleep apnea. Signals included in the polysomnography (PSG) montage are EEG, EMG, EOG, ECG, SpO2, airflow, CPAP pressure, CPAP flow, plethysmography, position, pulse, light, respiratory effort, snore.

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• SciCrunch
• 8 years ago - submitted by Sara Mariani

Provides tools and expertise in bio image analysis, histology, and microscopy. Facility allows for the preparation, visualization, and quantification of biological samples at the cellular and sub cellular levels. Researchers can choose to utilize our instruments independently or collaborate with our skilled staff through our fee-for-service options.

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• dkNET
• 2 years ago - submitted by Nicholas Anthony

A question answering web site and forum that focuses on neuroinformatics and neuroscience. Initially conceived by Istvan Albert's highly successful BioStar website within the Bioinformatics community, NeuroStars is born as an experiment to engage the Neuroinformatics community after some unfruitful attempts in StackExchange's Area51. Posts that are detailed and specific, written clearly and simply are welcome.

• Resource
• SciCrunch
• 13 years ago - by Anonymous

Standard specification for organizing and describing outputs of neuroimaging experiments. Used to organize and describe neuroimaging and behavioral data by neuroscientific community as standard to organize and share data. BIDS prescribes file naming conventions and folder structure to store data in set of already existing file formats. Provides standardized templates to store associated metadata in form of Javascript Object Notation (JSON) and tab-separated value (TSV) files. Facilitates data sharing, metadata querying, and enables automatic data analysis pipelines. System to curate, aggregate, and annotate neuroimaging databases. Intended for magnetic resonance imaging data, magnetoencephalography data, electroencephalography data, and intracranial encephalography data.

• Resource
• RRID-Legacy
• 9 years ago - submitted by Krzysztof Gorgolewski

Clinical oncology database sourced from hospital registry data collected in Commission on Cancer-accredited facilities. These data are used to analyze and track patients with malignant neoplastic diseases, their treatments, and outcomes.

• Resource
• RRID
• 2 years ago - by Anonymous