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Producer and supplier of a collection of mice bearing spontaneous mutations. These mice contribute to a better understanding of the genetic bases of neurological, neuromuscular, sensory, metabolic, skeletal/craniofacial and developmental disorders and conditions such as diabetes, obesity and heart disease.

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• SciCrunch
• 15 years ago - by Anonymous

Center dedicated to providing statistical information to guide policies to improve the health of the American people. An affiliate of the Center for Disease Control and Prevention.

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• SciCrunch
• 15 years ago - submitted by Andrea Stagg

Core provides mass spectrometric sequencing and quantitation of peptides and proteins to support basic, translational, and clinical research programs at MSK. Utilizes modern high-resolution mass spectrometry and nanoscale liquid chromatography in conjuction with biochemical processing of samples with the end goal of determining the identity, relative abundance, and presence of post translational modifications from purified components, cell lysates, tissues, and select fluid such as cerebral spinal fluid. Advice is provided by the Core staff to facilitate the design, execution, and analysis of experiments.

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• RRID
• 11 months ago - submitted by Patrick Badua

The main goal of CASP is to obtain an in-depth and objective assessment of our current abilities and inabilities in the area of protein structure prediction. To this end, participants will predict as much as possible about a set of soon to be known structures. These will be true predictions, not ''post-dictions'' made on already known structures. Sponsors: This resource is supported by the US National Library of Medicine (NIH/NLM), National Institute of General Medical Sciences (NIH/NIGMS), BioSapiens Network of Excellence, and HP Invent. Keywords: Clinical, Technique, Protein, Prediction, Structure,

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• SciCrunch
• 14 years ago - by Anonymous

NSERC aims to make Canada a country of discoverers and innovators for the benefit of all Canadians. The agency supports university students in their advanced studies, promotes and supports discovery research, and fosters innovation by encouraging Canadian companies to participate and invest in postsecondary research projects. NSERC researchers are on the vanguard of science, building on Canada''s long tradition of scientific excellence.

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• SciCrunch
• 17 years ago - submitted by Andrea Stagg

Spatial Collaborative Services combines expertise and technology from VAIs Genomics Core and Optical Imaging Core to offer investigators a seamless pipeline for spatial imaging. Services include consultation, histology preparation, sequencing and imaging based spatial platforms.

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• SciCrunch
• 10 months ago - submitted by Edyta Vieth

his table shows the metadata and links to sources of the data and citations associated with the publicly available metagenome sequences used in the Dinsdale, Edwards, et al., analysis of 87 different metagenomes. The links will take you to the annotated sequences in the metagenomics SEED, CAMERA, and the NCBI Short Read Archve. Please note that all metagenomes are currently available to download via the ftp links, some are available in the meta-RAST, and other links will be added as soon as they become available. Citations for individual metagenomes will also be added as and when they become available. DNA sequences for all metagenomes are avaialble via anonymous FTP. Sponsor. This project was supported by the Gordon and Betty Moore Foundation Marine Microbial Initiative, National Science Foundation grants (F.R. and D.L.V.), a Department of Commerce ATP grant (F.R.), a National Research Initiative Competitive Grant from the USDA Cooperative State Research, Education and Extension Service (B.W.), the National Institute of Allergy and Infectious Diseases, the National Institutes of Health and the Department of Health and Human Services (R.S.).

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• SciCrunch
• 17 years ago - by Anonymous

One of the largest public universities in Mexico.

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• SciCrunch
• 17 years ago - submitted by Christie Wang

Software package for quantifying transposable elements at a locus level for RNAseq datasets. TElocal base algortihm is derived from the published TEtranscripts tool.

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• RRID
• 10 months ago - by Anonymous

Organization that facilitates spinal cord injury research and care. By accelerating the translation of discoveries and best practices into improved treatments, it aims to improve the lives of people living with SCI.

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• SciCrunch
• 14 years ago - by Anonymous

The Salk Institute conducts research within three major areas of study: Molecular Biology and Genetics; Neurosciences; and Plant Biology. Six key areas represent strategic research priorities: Chemistry and Proteomics; Stem Cell Biology; Cell Biology; Regulatory Biology; Metabolic Research; and Computational and Theoretical Biology.

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• SciCrunch
• 16 years ago - by Anonymous

Core provides access to advanced imaging and analytical instrumentation, expert technical support, hands-on training, and collaborative project support. Services include high-resolution imaging through Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy (TEM) to examine surface features, internal structures, microstructures, nanoparticles, biological specimens, and engineered materials at micro- to nanoscale resolution; X-Ray Diffraction (XRD) for phase determination and crystallographic analysis; Atomic Force Microscopy (AFM) for nanoscale surface characterization. Provides solid analyzer and rheometer for evaluating material properties and behavior. Specialized sample preparation services include polishing, ultramicrotomy, sputter coating, and other preparation techniques needed for microscopy and materials analysis. Individualized, non-credit instruction is available for instrument operation and sample prep techniques. Offers expert support with sample preparation, data acquisition, sample analysis, troubleshooting, and preparation of results for reports, proposals, presentations, and publications.

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• RRID
• 9 months ago - submitted by Rooban Venkatesh K G Thirumalai

The Transgenic Hydra Facility is a non-profit facility in the laboratory of Thomas Bosch at the University of Kiel that assists scientists to use and to develop transgenic Hydra polyps. Our mission is to provide investigators access to the latest technology for the efficient production of transgenic polyps. We particularly encourage scientists from laboratories lacking the infrastructure for transgenic Hydra technologies to use our services. Abstract: Understanding the evolution of development in large part relies on the study of phylogenetically old organisms. Cnidarians, such as Hydra, have become attractive model organisms for these studies. However, despite long-term efforts, stably transgenic animals could not be generated, severely limiting the functional analysis of genes. Here we report the efficient generation of transgenic Hydra lines by embryo microinjection. One of these transgenic lines expressing EGFP revealed remarkably high motility of individual endodermal epithelial cells during morphogenesis. We expect that transgenic Hydra will become important tools to dissect the molecular mechanisms of development at the base of the Metazoan tree. Sponsors: Financial support for this research was provided by the German Research Foundation [Deutsche Forschungsgemeinschaft Grants B0848/13 and SFB617.

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• SciCrunch
• 17 years ago - by Anonymous

Research institute of the Chinese Academy of Sciences, in Shanghai, established on July 3, 1999. When it was created, it was one of four basic science research institutions of China.

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• SciCrunch
• 15 years ago - submitted by Andrea Stagg

Software quality-assurance layer for pathway enrichment interpretation that converts enrichment term lists into context-conditioned, evidence-linked, schema-bounded claims and assigns PASS/ABSTAIN/FAIL via predefined, rule-based audit gates (stability, context validity stress tests, evidence-link integrity, and contradiction checks), producing decision-grade reports with audit logs. The LLM is confined to proposal-only steps; final decisions are mechanical and reproducible.

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• RRID
• 9 months ago - by Anonymous

Tools for the integration of data from various sources (public and confidential), for the generation and validation of computer models for toxic effects, libraries for the development and seamless integration of new algorithms, and scientifically sound validation routines. The goal of OpenTox is to develop an interoperable predictive toxicology framework which may be used as an enabling platform for the creation of predictive toxicology applications. OpenTox is relevent for users from a variety of research areas: Toxicological and chemical experts (e.g. risk assessors, drug designers, researchers) computer model developers and algorithm developers non specialists requiring access to Predictive Toxicology models and data OpenTox applications can combine multiple web services providing users access to distributed toxicological resources including data, computer models, validation and reporting. Applications are based on use cases that satisfy user needs in predictive toxicology. OpenTox was initiated as a collaborative project involving a combination of different enterprise, university and government research groups to design and build the initial OpenTox framework. Additionally numerous organizations with industry, regulatory or expert interests are active in providing guidance and direction. The goal is to expand OpenTox as a community project enabling additional expert and user participants to be involved in developments in as timely a manner as possible. To this end, our mission is to carry out developments in an open and transparent manner from the early days of the project, and to open up discussions and development to the global community at large, who may either participate in developments or provide user perspectives. Cooperation on data standards, data integration, ontologies, integration of algorithm predictions from different methods, and testing and validation all have significant collaboration opportunities and benefits for the community. OpenTox is working to meet the requirements of the REACH legislation using alternative testing methods to contribute to the reduction of animal experiments for toxicity testing. Relevant international authorities (e.g., ECB, ECVAM, US EPA, US FDA) and industry organizations participate actively in the advisory board of the OpenTox project and provide input for the continuing development of requirement definitions and standards for data, knowledge and model exchange. OpenTox actively supports the development and validation of in silico models and algorithms by improving the interoperability between individual systems (common standards for data and model exchange), increasing the reproducibility of in silico models (by providing a quality source of structures, toxicity data and algorithms) and by providing scientifically sound and easy-to-use validation routines. OpenTox is committed to the support and integration of alternative testing methods using in vitro assay approaches, systems biology, stem cell technology, and the mining and analysis of human epidemiological data. Hence the framework design must take into account extensibility to satisfy a broad range of scientific developments and use cases.

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• SciCrunch
• 17 years ago - by Anonymous

A portal that provides a province-wide, population-based cancer control program for the residents of British Columbia and the Yukon. The BC Cancer Agency''s mandate covers the spectrum of cancer care, from prevention and screening, to diagnosis, treatment, and through to rehabilitation. The BC Cancer Agency''s mandate is driven by a three-fold mission: 1. To reduce the incidence of cancer; 2. To reduce the mortality rate of people with cancer; 3. To improve the quality of life of people living with cancer. This mission drives everything we do, including providing screening, diagnosis and care, setting treatment standards, and conducting research into causes of, and cures for, cancer. The BC Cancer Agency operates five regional cancer centers, providing assessment and diagnostic services, chemotherapy, radiation therapy, and supportive care. Each of the BC Cancer Agency''s centers delivers cancer treatment based on provincial standards and guidelines established by the Agency. We work in partnership with communities to provide a network of chemotherapy clinics so patients can receive care closer to home. Research is an essential part of the BC Cancer Agency''s mission to not only find the causes of cancer, but to find better treatments for prolonged life and better quality of life. With direct links between the BC Cancer Agency''s physicians and researchers at our five centers, the Deeley Research Centre (located in Victoria) and the BC Cancer Agency''s Research Centre (located in Vancouver), we can quickly translate new discoveries into clinical applications. The BC Cancer Agency''s Research Centre includes eight specialty laboratories including the Genome Sciences Centre, and the Terry Fox Laboratory. The BC Cancer Foundation raises funds for cancer research and enhancements to care at the BC Cancer Agency.

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• SciCrunch
• 16 years ago - by Anonymous

Software package to provide interface for the most frequent tasks of survival analysis, with focus on the needs of clinical oncology. The syntax follows the tidyverse philosophy and is made to be used in a pipeline.

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• RRID
• 9 months ago - by Anonymous

Consortium to comprehensively map long-distance brain connections and their variability. It is acquiring data and developing analysis pipelines for several modalities of neuroimaging data plus behavioral and genetic data from healthy adults.

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• SciCrunch
• 16 years ago - by Anonymous

The Gregor Mendel Institute of Molecular Plant Biology (GMI) was founded by the Austrian Academy of Sciences in 2000 in the form of a company to promote research excellence within the field of plant molecular biology. It is the only international centre for basic plant research in Austria. The GMI is located at the Vienna Biocenter Campus within the purpose-built Austrian Academy of Sciences Life Sciences Center Vienna, completed in January 2006. The Vienna Biocenter Campus, which encompasses both independent and academic research institutes as well as biotechnology companies, provides an ideal environment for the GMI. Neighbouring institutes include the Research Institute of Molecular Pathology (IMP), the Institute of Molecular Biotechnology (IMBA), as well as the Max F. Perutz Laboratories of the University of Vienna and of the Medical University of Vienna. Research at the GMI is curiosity driven and covers many aspects of molecular genetics, from basic mechanisms of epigenetics to population genetics. Arabidopsis thaliana is used as the primary model organism, and research groups are evaluated annually by an international external Scientific Advisory Board. The working language of the GMI is English. Research at the GMI is carried out by independent research groups, led either by senior group leaders with contracts of unlimited duration, or junior group leaders with temporary (5 3 years) appointments. GMI''s research activities are supported by its administration and a platform consisting of the GMI''s own services, including state-of-the-art plant growth facilities, as well as joint services with the Research Institute of Molecular Pathology and the Institute of Molecular Biotechnology Funding Our employees are expected to apply for grants and additional financial support from various external national and international funding bodies. The list below provides an overview of the funding opportunities that could be relevant for GMI members. The Frderassistent of the FFG (in German) or the Frderkompass of the Federal Ministry of Transport, Innovation and Technology (in German) can also be used to find appropriate funding.

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• SciCrunch
• 17 years ago - by Anonymous