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Highly controllable fluorescence microscopy Illumination System which offers broad spectrum LED illumination for imaging most common fluorophores. System offers precise control over wavelength irradiance and shuttering. Used for LED microscope lighting.
Redesigned ORCA-Flash4.0 LT+ featuring 82 % peak quantum efficiency brings all advantages of sCMOS technology wide field of view, low light sensitivity, and large dynamic range increased flexibility and sensitivity of a scientific CMOS camera., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025.
Core helps investigators tackle wide range of research questions, from gene expression to cell motility, and is committed to providing training in microscopy best practices. Service requests are placed through CrossLab Solutions.
Software tool as PacBio assembly tool suite.
Software tool used for improved phased assembly.IPA assembly for Hifi PacBio reads. Official PacBio software for HiFi genome assembly.
Core provides equipment in microscopy and digital imaging. Primary focus is technology transfer and provision of facilities for acquisition and analysis of histological and cytological preparations. Provides training in the use of imaging instrumentation and in the application of image analysis procedures for generation of quantitative data.
Provides DRSC Drosophila cell-based screening, TRiP Drosophila fly stock production, Bioinformatics software tools and data access. Functional genomics platform for needs of Drosophila and broader community.Online tools include DIOPT for identification of orthologs (yeasts, worm, fly, frog, fish, mouse, rat, human),DIOPT-DIST for identification of human orthologs and links to disease, UP-TORR for RNAi reagent identification based on up-to-date gene annotations,DGET analysis of gene lists in the context of RNAseq data from modENCODE and others,Find CRISPRs and CRISPR efficiency evaluation online tools for CRISPR-Cas9 genome editing, FlyPrimerBank resource of pre-computed qPCR primers,RSVP RNAi fly stock validation database (data for TRiP, VDRC, NIG-Japan fly stocks), GeneLookup and Screen Summary views of DRSC cell screen data sets.
Manually curated database containing information on extracellular and circulating non-coding RNAs.You can search for RNAs typing in text area molecule of interest or you can browse database. Initially published in 2012, foreseeing relevance of ncRNAs as non-invasive biomarkers.miRandola 2017 is effort to update and collect accumulating information on extracellular ncRNAs that is spread across scientific publications and different databases with implemented new web interface.
Manually curated database of exosomal proteins, RNA and lipids. Web based compendium of exosomal cargo. Database catalogs information from both published and unpublished exosomal studies. Mode of exosomal purification and characterization, biophysical and molecular properties are listed.
Software tool for robust cell segmentation for fission yeast transillumination images.Used for robust segmentation of fission yeast micrographs, especially those with quality challenged images.
Software tool as novel non-linear learning algorithm for simultaneous binary classification and subtype identification. Can handle imaging and non-imaging data and can find applications in exploratory analyses other than clustering of brain images.Software performs clustering of heterogenous disease patterns within patient group.
Software as collection of speech analysis, modification and resynthesis tools.
Independent biomedical research and science education organization in Grand Rapids, MI. Committed to improving health and changing lives of current and future generations through biomedical research and science education.
Software tool for non-linear normal mode analysis.
Software Python package to construct conformational ensemble of biomolecular system by integrating molecular simulations and experimental data. Performs ensemble reweighting using Bayesian Maximum Entropy approach.
Open source, community developed library that provides range of different methods, which include enhanced sampling algorithms, free energy methods, tools to analyze vast amounts of data produced by molecular dynamics simulations. PLUMED 2 is complete rewrite of the code in object oriented programming language C plus plus. This new version introduces greater flexibility and greater modularity, which both extends its core capabilities and makes it far easier to add new methods and CVs. It also has simpler interface with the MD engines and provides single software library containing both tools and core facilities.
Software tool used for predictions of molecular packing and interactions. General purpose coarse grained force field for molecular dynamics simulations of biomolecular systems Martini 3 is refined model with improved interaction balance, new bead types and expanded ability to include specific interactions representing, for example, hydrogen bonding and electronic polarizability.
Software tool as logical extension of Pepsi-SAXS method for small angle neutron scattering. Allows for explicit and implicit hydrogens, allows to specify deuteration level of sample and of buffer and exchange rate of labile hydrogens. Can also compute scattering intensity in absolute scale if sample concentration is provided. Can fit modelled profile on absolute scale within certain user specified margin. Instrumentation resolution is taken into account during processing of input data.
HANDEL-1 program to better understand normal human immune development by acquiring stromal and mucosal tissues from infant and pediatric organ donors and to create novel and essential dataset informing immune system development in collaborative research project that leverages shared access to various tissues in conjunction with existing HANDEL-P program that seeks to understand development of pancreas and islet microenvironment in early life.
Software R toolkit for inference, visualization and analysis of cell-cell communication from single cell data.Quantitatively infers and analyzes intercellular communication networks from single-cell RNA-sequencing data. Predicts major signaling inputs and outputs for cells and how those cells and signals coordinate for functions using network analysis and pattern recognition approaches. Classifies signaling pathways and delineates conserved and context specific pathways across different datasets.