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Molecular Pathology Section offers clinical grade sample processing and molecular testing for research cases.All services are performed in CLIA certified environment and all molecular assays are accompanied by full data analysis including bioinformatics analysis for NGS data.
Research Histology Section provides range of standardized paraffin histology procedures that can be tailored to specific research needs.Services include tissue grossing/cassetting, paraffin processing, sectioning, routine and special stains. We specialize in immunohistochemistry and antibody optimization procedures.
Core facilitates access, generation, and usage of novel in vitro mouse and human organoid systems to promote innovative basic and translational research and disease modeling. Provides expertise in genome editing technologies for targeted knock outs, point mutations, and reporter generation in organoid systems. Provides many specialized medias and reagents to support most common organoid culture systems.
Core supports access to and expertise in data management, analyses, and mapping and data visualization of population based databases. These databases are ideal for studies requiring access to large samples of patients and/or providers; examination of trends in treatment, screening, or other healthcare services; impact of policy changes or recommendations on healthcare services; investigating dissemination of evidence based technologies and interventions; disparities of treatment or other health care services between groups; geographic distributions of cancer patients and relationships with other geospatial data.
Core, in collaboration with Colorado Genetics Lab, provides cytogenetic and cytogenomic research services. Services include tissue culture, chromosome analysis, fluorescence in situ hybridization (FISH), and chromosomal microarray. Offers design and development of customized FISH probes.Available for consultation on study design and data analysis.
Core provides Human Immune System as preclinical in vivo model to study human immune system in experimental tractable animal model e.g. immune response to human tumors that readily grow in HIS-mice. Offers immune expertise, experimental procedures and data analysis of immune based assays, such as flow cytometry.
Biorepository Section provides services to support biobanking, clinical trials, and research studies. Provides access to patient specimens collected from clinical and research procedures that are handled, processed, analyzed, and interpreted in uniform manner. Services include, collection, processing, storage, clinicopathological annotation, and distribution of biospecimens.
Provides investigators with capabilities to identify, characterize, and quantify biomolecules present in tissues, cells, and biological fluids. Facility houses both Proteomics and Metabolomics Cores, and aims to assist members with solving difficult or previously intractable problems in biomedical research. Methods for biomolecule isolation, separation, quantification, identification and bioinformatics analysis, together with expert guidance in study design, are integrated into expertise offered by the Facility.
Core facilitates access to tools including shRNA, ORF, CRISPR to investigate gene function on genome wide scale. Provides protocols and expertise for use of these genomics tools. Serves as forum for scientific exchange and discussion in the field of functional genomics.Sign in to iLab using University of Colorado credentials.
Provides expertise and infrastructure to facilitate drug discovery at different stages of development pipeline, including assay development and validation, high throughput screening and image based high content screening discovery, validation and optimization, and in vitro and in vivo pharmacology including pharmacokinetics and pharmacodynamics as well as toxicology.Sign in to iLab using University of Colorado credentials.
Facilitates clinical and translational studies by dissecting immune based mechanisms with diagnostic and therapeutic applications. Offers assays including immunophenotyping and functional characterization, multicolor fluorescence tissue imaging, multiplex cytokine analysis, and cellular assays.Sign in to iLab using University of Colorado credentials.
GSR provides genome-wide analyses of DNA sequence, transcriptomes, epigenetics and cytogenomics using next generation sequencing (NGS) and gene microarrays; and single cell genomic and transcriptomic analyses including single cell immune profiling and spatial gene expression.
Cancer focused bioinformatics group that assists in all needs related to omics and big data. We assist our collaborators with experimental design, data processing, interpretation, generating publication-quality figures, and preparing manuscripts and grants.
Supports basic and translational research projects in biomedical research. CTSR produces hybridomas/monoclonal antibodies to enhance basic research and preclinal studies and makes recombinant proteins for mechanistic and structural studies on proteins.Provides multiple platforms and analytic modules for real time live-cell imaging of cultured cells and organoids to enhance analysis of cancer cell biology. In addition, we maintain a collection of authenticated human cell lines for use in biomedical research. Sign in to iLab using University of Colorado credentials.
Biostatistics provides quantitative support for planning, design, analysis, and presentation of basic science, clinical, and epidemiological investigations. We are dedicated to delivering high quality, methodically developed results to improve patient outcomes and clinical care.
Enables noninvasive imaging of animal models of human disease. Provides access and training on state-of-the-art animal scanners (MRI, CT, optical, PET/SPECT) for live imaging on rodents, perfoms all animal handling and assist with image analysis to establish imaging biomarkers.
Biomedical Research Computing Facility as core for Biomedical Research Support. Provides small, centrally managed compute clusters and storage, suitable for local, interactive computing, to biomedical research groups.
Software tool for learning fundamentals of RSLogix ladder logic programming.
Database that aggregates, harmonizes and links records of various publication types from diverse sources, including Crossref and PubMed Central using automated routines and artificial intelligence technologies. Publications, ranging from articles published in scholarly journals, books and book chapters, to preprints and conference proceedings. All publications are contextualized with linked data sets, funding, publications, patents, clinical trials, and policy documents. You can also view associated categories, funders, institutions, and researcher profiles.
Light Microscopy and Scanning Electron Microscopy Facility managed by the Biology Department.