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APBS is a software package for modeling biomolecular solvation through solution of the Poisson-Boltzmann equation (PBE), one of the most popular continuum models for describing electrostatic interactions between molecular solutes in salty, aqueous media. APBS was designed to efficiently evaluate electrostatic properties for such simulations for a wide range of length scales to enable the investigation of molecules with tens to millions of atoms. It also provides implicit solvent models of nonpolar solvation which accurately account for both repulsive and attractive solute-solvent interactions. APBS uses FEtk (the Finite Element ToolKit) to solve the Poisson-Boltzmann equation numerically. FEtk is a portable collection of finite element modeling class libraries written in an object-oriented version of C. It is designed to solve general coupled systems of nonlinear partial differential equations using adaptive finite element methods, inexact Newton methods, and algebraic multilevel methods.

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• SciCrunch
• 17 years ago - by Anonymous

National institute that reduces the burden of human illness and dysfunction from environmental causes by, defining how environmental exposures, genetic susceptibility, and age interact to affect an individual''s health. Its mission is to discover how the environment affects people in order to promote healthier lives. Achieving this mission depends on a set of core values that apply to all activities of the Institute: * Research excellence (innovation; discovery of new scientific knowledge and technology); * Management excellence; and * Community outreach, education, and involvement. At NIEHS and the National Toxicology Program, they engage in a special form of public service - producing scientific knowledge that promotes individual and public health. The Institute is uniquely positioned to help prevent disease and transform new scientific knowledge into improvements in human health. There are many opportunities before us to build and expand the contributions of the NIEHS: * Foster research on environmental triggers of disease; * Communicate advances in environmental health sciences to the public; * Foster training and development of emerging young environmental health scientists and practitioners; * Enhance translation of knowledge from research to disease prevention; and * Foster safety assessment research on chemicals and other environmental factors. The fulfillment of this mission requires the partnership and effort of everyone in the environmental health sciences communities.

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• SciCrunch
• 17 years ago - submitted by Andrea Stagg

Device for 2 kHz eye/gaze-tracking solution supporting both monocular and binocular tracking with single mechanical configuration. Interchangeable lenses support tracker distances from 60 cm to over 160 cm for fMRI applications. TRACKPixx3 does not require a dedicated PC to process eye images and generate gaze information. All image processing is performed within TRACKPixx3 hardware. Gaze data can be logged within the TRACKPixx3 and retrieved by the testing PC with a simple low-latency USB interface. TRACKPixx3 video feed can be accessed directly through a console display for real-time visualization and adjustment of the tracker. These video feeds can also be accessed through the USB interface for remote control of the TRACKPixx3.

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• RRID
• 11 months ago - submitted by Lindsey Fraser

Criterion Ventures is launching a new venture that will adapt existing financial services and connect them with consumers through affinity groups to address the needs of the cash market of healthcare. Currently, the healthcare industry is dominated by an insurance market. But sitting next to the insurance market is a $300 billion/year cash market for health care. This cash market lacks the rational pricing, products, services and intermediaries needed to deliver health care affordably and in a way that maximizes access. In the end, consumers are not getting the best value per dollar spent. By introducing and bringing to scale innovative products and services, and connecting them to consumers through existing affinity groups whose members are struggling with the impact of the cash portion of healthcare, we will be able to rationalize the market. By creating a rational market we will bring greater value to consumers for their healthcare dollars and increase access to care. The business will draw revenues from four sources: Charging transaction fees to consumers who use our products Charging interest to consumers who take advantage of our lines of credit offerings Interest earned on deposits that we or our partners will hold for consumers Charging management fees to affinity groups for setting up their customized set of products and services. Partners. Thomas H. Cochran, Managing Director, CivilCredit Advisors Catherine (Cathy) Dunham, Director, Access Project Richard Eskow, CEO, Health Knowledge Systems Tim Freundlich, Founder and Managing Principal, Good Capital; Director of Strategic Initiatives, Calvert Foundation Ben Geyerhahn, Principal, Hudson TG Kevin Jones, Founding Principal, Good Capital Claudia Machaver, Consultant Robert Mittman, Founder, Facilitation, Foresight, Strategy Sara Olsen, Founding Partner, SVT Group Mark Rukavina, Executive Director, Access Project Michael Tobman, Principal, Hudson TG Dana Wright, Founder, Take Action, Inc.

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• SciCrunch
• 17 years ago - by Anonymous

The NIH is comprised of the Office of the Director and 27 Institutes and Centers. The Office of the Director is the central office at NIH. The OD is responsible for setting policy for NIH and for planning, managing, and coordinating the programs and activities of all the NIH components. The NIH Director provides overall leadership to NIH activities in both scientific and administrative matters. Although each institute within the NIH has a separate mission, the NIH Director plays an active role in shaping the agency''s research agenda and outlook. With a unique and critical perspective on the mission of the entire NIH, the Director is responsible for providing leadership to the institutes for identifying needs and opportunities, especially for efforts that involve several institutes. The NIH Director is assisted by the Principal Deputy Director, who shares in the overall direction of the agency''s activities. In carrying out these responsibilities, the NIH Director stays informed about program priorities and accomplishments through regular staff meetings, discussions, and briefing sessions with OD and institute staff. The Director also receives input from: * the extramural scientific community, including both individual researchers and scientific organizations * patient advocacy and voluntary health groups that deal directly with NIH or indirectly through Congress and the media * the Congress and the Administration the Council of Public Representatives, which brings public views to NIH. Ongoing discussions with these groups and others provides the basis for an established framework within which priorities for the agency are identified, reviewed, and justified. Dr. Francis Collins, the NIH Director, has outlined five key themes for NIH: * Applying high throughput technologies to understand fundamental biology, and to uncover the causes of specific diseases * Translating basic science discoveries into new and better treatments * Putting science to work for the benefit of health care reform * Encouraging a greater focus on global health * Reinvigorating and empowering the biomedical research community Program offices in the Office of the Director are responsible for stimulating specific areas of research throughout NIH and for planning and supporting research and related activities. Current program areas are: minority health, women''s health, AIDS research, disease prevention, and behavioral and social sciences research. Program offices within the Office of the Director fund research through the institutes.

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• SciCrunch
• 15 years ago - submitted by Andrea Stagg

Software R tools for Blaser Lab Data Analysis. Package includes commonly used functions for R analysis in the Blaser Lab.

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• RRID
• 10 months ago - submitted by Brad Blaser

This document defines the processes and standards that all FLTK developers must follow when developing and documenting FLTK, and how trouble reports are handled and releases are generated. The purpose of defining formal processes and standards is to organize and focus our development efforts, ensure that all developers communicate and develop software with a common vocabulary/style, and make it possible for us to generate and release a high-quality GUI toolkit which can be used with a high degree of confidence. Much of this file describes the existing practices that have been used up through FLTK 1.1.x, however I have also added some new processes/standards to use for future code and releases. The fltk-dev mailing list and fltk.development newsgroup are the primary means of communication between developers. All major design changes must be discussed prior to implementation. Specific Goals The specific goals of the FLTK are as follows: Develop a C++ GUI toolkit based upon sound object-oriented design principles and experience. (*) Minimize CPU usage (fast). (*) Minimize memory usage (light). (*) Support multiple operating systems and windowing environments, including UNIX/Linux, MacOS X, Microsoft Windows, and X11, using the native graphics interfaces. (*) Support OpenGL rendering in environments that provide it. (*) Provide a graphical development environment for designing GUI interfaces, classes, and simple programs. (*) Support UTF-8 text. Support printer rendering in environments that provide it. Support schemes, styles, themes, skinning, etc. to alter the appearance of widgets in the toolkit easily and efficiently. The purpose is to allow applications to tailor their appearance to the underlying OS or based upon personal/user preferences. Support newer C++ language features, such as templating via the Standard Template Library (STL), and certain Standard C++ library interfaces, such as streams. However, FLTK will not depend upon such features and interfaces to minimize portability issues. Support intelligent layout of widgets. Many of these goals are satisfied by FLTK 1.1.x (*), and many complex applications have been written using FLTK on a wide range of platforms and devices. Development of the remaining features is proceding for FLTK 2.0 with a new, namespace-based API. While 2.0 offers some limited 1.x source compatibility, the changes to the underlying widget classes are significant enough to prevent full compatibility. Software Development Practices Documentation All widgets are documented using the Doxygen software; Doxygen comments are placed in the header file for the class comments and any inline methods, while non-inline methods should have their comments placed in the corresponding source file. The purpose of this separation is to place the comments near the implementation to reduce the possibility of the documentation getting out of sync with the code. All widgets must have a corresponding test program which exercises all widget functionality and can be used to generate image(s) for the documentation. Complex widgets must have a written tutorial, either as full text or an outline for later publication The final manuals are formatted using the HTMLDOC software. Sponsor. Easy Software Products

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• SciCrunch
• 17 years ago - by Anonymous

Max Planck Institute for Biophysical Chemistry in Göttingen is a research institute of the Max Planck Society. Currently, 850 people work at the institute, about half of them are scientists.

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• SciCrunch
• 15 years ago - submitted by Andrea Stagg

Web-based, and open-source platform designed to predict and optimize CRISPR-Cas13 guide RNAs (gRNAs) for targeting and knocking down specific RNA molecules. It is specifically used to select the most efficient guide RNAs for RfxCas13d to maximize RNA degradation (knockdown) efficacy, with applications in transcriptome engineering, functional genomics, and antiviral therapy.

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• RRID
• 10 months ago - by Anonymous

MMV, a not-for-profit public-private partnership, was established as a foundation in Switzerland in 1999. Our mission is to reduce the burden of malaria in disease-endemic countries by discovering, developing and facilitating delivery of new, effective and affordable antimalarial drugs. Our vision is a world in which these innovative medicines will cure and protect the vulnerable and under-served populations at risk of malaria, and help to ultimately eradicate this terrible disease. Sponsors/Donors: -Bill and Melinda Gates Foundation -CRIMALDDI -ExxonMobil -Irish Aid -National Institutes of Health -Netherlands Ministry of Foreign Affairs -Rockefeller Foundation (former donor) -Secretaria de Estado de Cooperacin Internacional (Spanish Agency for International Cooperation) -Swiss Agency for Development and Cooperation -UK Department for International Development -USAID -Wellcome Trust -World Bank -World Health Organization

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• SciCrunch
• 17 years ago - by Anonymous

An agency of the United States Department of Health and Human Services, one of the United States federal executive departments that is responsible for protecting and promoting public health through the regulation and supervision of food safety, tobacco products, dietary supplements, prescription and over-the-counter pharmaceutical drugs (medications), vaccines, biopharmaceuticals, blood transfusions, medical devices, electromagnetic radiation emitting devices (ERED), cosmetics and veterinary products. The FDA also enforces other laws, notably Section 361 of the Public Health Service Act and associated regulations, many of which are not directly related to food or drugs. These include sanitation requirements on interstate travel and control of disease on products ranging from certain household pets to sperm donation for assisted reproduction. (Wikipedia)

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• SciCrunch
• 17 years ago - submitted by Andrea Stagg

Core to accelerate scientific discovery in G protein-coupled receptors (GPCRs) physiology and pharmacology. Provides services to identify signal transduction processes that are specific to their GPCR of interest (such as opioid, cannabinoid and muscarinic) that is either natively present or expressed heterologously in cell systems. Assists investigators with drug development studies. Support researchers with assay development and optimization, pilot data, and grant assistance. Houses instrumentation used.

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• RRID
• 9 months ago - by Anonymous

GIN-IE is a high precision system for extracting protein/gene interactions, interaction cue words, and directionality from the literature. Syntax-aware inferences about the roles of the entities are made by using the syntactic and dependency parse tree structures of the sentences. Negation and speculation are frequently occurring language phenomena that modify the factuality of the information contained in text. GIN-IE detects and distinguishes interactions that are extracted from negated or speculative sentences. GIN-IE has been integrated with the NCIBI PubMed daily update and processing pipeline. The extracted interactions are accessible through MimiWeb.

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• SciCrunch
• 17 years ago - by Anonymous

Executive branch department of the federal government charged with coordinating and supervising all agencies and functions of the government directly related to national security and the United States Armed Forces.

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• SciCrunch
• 17 years ago - submitted by Andrea Stagg

Core provides comprehensive proteomic analyses using LC-MS platforms, supporting post-translational modifications, protein-protein interactions, spatial proteomics, and single-cell workflows with bioinformatics.

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• SciCrunch
• 9 months ago - submitted by Edyta Vieth

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on May 18,2023.

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• SciCrunch
• 16 years ago - by Anonymous

Created by the Government of Canada in 1997 to undertake world-class research and technology development to benefit Canadians by investing in facilities and equipment, universities, colleges, research hospitals and non-profit research institutions to attract and retain the world's top talent, training the next generation of researchers, supporting private-sector innovation and creating high-quality jobs.

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• SciCrunch
• 16 years ago - by Anonymous

Canadian national user facility located at INRS-EMT in Varennes, Quebec, designed to develop and apply high-power, ultrafast lasers for advanced scientific research. It produces intense, synchronized light pulses spanning from THz to hard X-rays for dynamic imaging, materials science, and medical applications. Home of the most powerful laser in Canada with 750 TW and high repetition rate laser systems to explore novel phenomena in matter with ultrafast tools.

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• RRID
• 9 months ago - submitted by Heide Ibrahim

The Society for Neuroscience (SfN) is a nonprofit membership organization of scientists and physicians who study the brain and nervous system. Since its inception in 1969, the Society has grown from 500 members to over 40,000. Today, SfN is the world''s largest organization of scientists and physicians devoted to advancing understanding of the brain and nervous system. SfN''s mission is to: 1. Advance the understanding of the brain and the nervous system by bringing together scientists of diverse backgrounds, by facilitating the integration of research directed at all levels of biological organization, and by encouraging translational research and the application of new scientific knowledge to develop improved disease treatments and cures. 2. Provide professional development activities, information, and educational resources for neuroscientists at all stages of their careers, including undergraduates, graduates, and postdoctoral fellows, and increase participation of scientists from a diversity of cultural and ethnic backgrounds. 3. Promote public information and general education about the nature of scientific discovery and the results and implications of the latest neuroscience research. Support active and continuing discussions on ethical issues relating to the conduct and outcomes of neuroscience research. 4. Inform legislators and other policymakers about new scientific knowledge and recent developments in neuroscience research and their implications for public policy, societal benefit, and continued scientific progress..

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• SciCrunch
• 16 years ago - by Anonymous

Private non-profit laboratory at the University of Chicago that works on scientific discovery of biodiversity, understanding the environment and exploring the human condition through education and research.

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• SciCrunch
• 16 years ago - by Anonymous