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Facility Oxford ICP-RIE Plaslab 180 utilizes a 3kW RF power supply to generate a remote plasma of Cl2, BCl3, H2, Ar, NF3, O2, SF6, and/or C4F8 gas species that can be further accelerated (300W table bias) toward a substrate resulting in a combination of physical and chemical dry etching for material removal. The turbomolecular pumped system achieves a base pressure < 1E-7 Torr and is equipped with chuck temperature control from -110 to 350 degrees C. Advanced dry etching system combining inductively coupled plasma (ICP) and reactive ion etching (RIE) for highly anisotropic, high-precision material removal in semiconductor and nanofabrication processes.
Facility plasma-enhanced chemical vapor deposition (PECVD) system from AGS utilizes plasma decomposition of silane (SiH4) in in presence of an oxygen or nitrogen source to deposit SiO2 and Si3N4 dielectric thin films. The capacitive coupled plasma reduces the required temperature for deposition to a minimum of ~150degC. A plasma-enhanced chemical vapor deposition system is used to deposit high-quality thin films at reduced temperatures for semiconductor and materials applications.
Facility plasma-enhanced atomic layer deposition (PEALD) system from Arradiance utilizes high-speed pulse valves to sequentially deliver reactants that combine to deposit thin films on the surface of a sample at temperatures up to 300C. Eight precursor positions (4 metalorganic + 4 oxidizer) and three plasma gases (N2, O2, H2) enable a wide range of films and process optimization. Plasma-enhanced atomic layer deposition system used for conformal, atomic-scale thin film growth with excellent uniformity and thickness control.
Facility Angstrom Engineering EvoVac is a thin film deposition system based on evaporation of source material that can deposit a wide range of materials including metals and inorganic compounds. Resistive evaporation results when electrical current heats a boat filled with source material whereas electron beam evaporation utilizes filament emission and magnetic focusing of a high energy electron beam which is swept within a crucible of deposition material. The deposition processes occur in a vacuum to permit long mean free paths from indexed multi-pocket sources at rates and terminal thicknesses controlled using a quartz rate sensor. The substrate can be heated, rotated, and plasma cleaned to control film morphology, uniformity, and adhesion. Vacuum-based deposition system that uses an electron beam to evaporate materials for high-purity thin film coatings with precise thickness control.
Multi-user clean room facility where students and researchers can fabricate films, structures, and devices at micrometer and nanometer scale. Users must enter through the gowning area that contains garments required to protect the cleanroom from particles. The class 10,000 instruction area houses high temperature furnaces, physical vapor deposition systems, wet chemical benches, chemical storage, and electrical test equipment utilized by undergraduate courses. The class 1000 research area houses deposition, etching, thermal treatment, and metrology equipment to support sponsored research and graduate coursework. The class 100 research space hosts the most sensitive lithography process equipment. The utility chase houses support equipment such as water cooling, vacuum pumps, exhaust abatement, and compressed gas delivery systems.
Facility provides infrastructure and technical expertise for maintenance, breeding, and experimental use of Danio rerio. The facility ensures standardized husbandry, health monitoring, and traceability of zebrafish lines in compliance with regulatory and ethical guidelines. Services include colony management, maintenance and distribution of wild-type, mutant, and transgenic lines, and support for experimental workflows. The platform offers technical services such as embryo microinjection (e.g., genome editing using CRISPR/Cas9), phenotypic screening, fin clipping for genotyping, and in vitro fertilization. Training and technical support are available for zebrafish handling, experimental design, and data reproducibility.
Company designs and manufactures specialized laboratory equipment for in vitro research on blood vessels and soft tissues. Based in Vermont, they provide tools for studying vessel pressure, flow, and diameter, primarily used by researchers to understand vascular physiology and disease. Instruments for in-vitro research studies of pressurized, perfused, cannulated blood vessels.
Software pipeline to aid the curation of bird genome assemblies by identifying putative microchromosome scaffolds and moving them to start of the genome assembly FASTA file. Hi-C contact map can then be made using the MicroFinder-ordered assembly file for downstream manual curation. Conserved gene-set mapping and assembly ordering for manual curation of bird microchromosomes. Order FASTA file by microchromosome specific genes.
Software bioinformatics tool for Helicobacter pylori genotyping.
Our AJA International, Inc. ATC Orion is a thin film deposition system based on physical ablation of target material by five (2RF/3DC) independently powered magnetron sputter sources. Substrates with maximum diameter of 100mm are load lock transferred to main chamber on Molybdenum substrate holder with variety of features including heating, rotation, Z motion, and RF biasing. Main chamber vacuum system consists of turbo-molecular pump, gate valve, mechanical pump, and 3 vacuum gauges. Quartz crystal monitor may be employed internally for rate calibration. Internal interlocks protect system/user from aberrant power, water, and vacuum states. Labview-based computer control allows for process development and automated sequencing. Physical vapor deposition system that deposits uniform thin films using magnetron sputtering in controlled vacuum environment.
Software deterministic reproducibility evaluation toolkit for biological machine learning pipelines. Implements 18-assertion compliance evaluation across 5 dimensions: explicitness, data provenance, reproducibility, stability, and bounded deployment envelope. Includes synthetic example dataset for reviewer verification without patient data.
Custom system intended for flexible annealing or chemical vapor deposition processing at temperatures < 1000oC. Process and/or purge gases (Ar, 4%H2 in Ar, N2) are introduced via a manifold into the quartz tube at either atmospheric or sub-atmospheric pressures. The maximum sample size is 60mm (~2").
Software suite for analyzing and visualizing in situ gene expression data produced by Xenium Analyzer. Xenium Ranger provides flexible off-instrument reanalysis of Xenium In Situ data.
Software Python package for bulk segregant analysis (BSA) and QTL mapping from pooled whole-genome sequencing data. Takes variant call format (VCF) input and produces ranked candidate genomic regions and genes through sliding window analysis with tricube kernel smoothing, Z-score and G-statistic significance testing, and optional snpEff functional annotation. Supports recessive and dominant inheritance modes, multi-sample bulk pooling, and integration with Nextflow and Snakemake workflow managers. Distributed via PyPI, Bioconda, and Docker.
Software R package that provides comprehensive computational pipeline for predicting survival probabilities and risk groups in cancer patients. Includes dedicated modules to perform key steps such as data preprocessing, training/test splitting, and normalization.
Software R package to visualize genetic maps and QTL analysis. Provides graphical user interface to integrate, visualize and explore results from linkage and quantitative trait loci analysis, together with genomic information for autopolyploid species. The app is meant for interactive use and allows users to optionally upload different sources of information, including gene annotation and alignment files, enabling the exploitation and search for candidate genes in a genome browser. In its current version, 'VIEWpoly' supports inputs from 'MAPpoly', 'polymapR', 'diaQTL', 'QTLpoly', 'polyqtlR', 'GWASpoly', and 'HIDECAN' packages.
Local desktop and cloud-based bibliometric and network analysis platform offered through a licensed access model.Supports literature-centered bibliometric and scientometric workflows, and it can also be applied to custom datasets with or without associated literature papers, including broader general network analysis use cases.
Core empowers researchers from genomic, clinical, and basic sciences disciplines at Rush and beyond with cutting-edge bioinformatics resources. Provides guided data analysis and hypothesis-driven research, large-scale data analysis, analytical plan development and results interpretation, algorithm and script development for custom data processing. Provides innovative infrastructure tools, including the Research Private Cloud and scalable cloud-based solutions. Services include customized analytical solutions, data storage and management workflows, training and support for bioinformatics tools.
Core is CAP/CLIA-certified facility offering comprehensive next generation sequencing (NGS) and bioinformatics services. Supports flexible workflows from nucleic acid extraction and library preparation to sequencing and custom data analysis. Services include DNA/RNA extraction, quality checks, various types of RNA/DNA library prep, NGS, methylation, proteomics (Illumina IPP), metabolomics, lipidomics, pharmacogenomics, and microarray analysis, with options for end-to-end or modular support. Advanced instrumentation includes Illumina NovaSeq X Plus and 6000 platforms, MiSeqDX, Hamilton , Eppendorf, and Tecan liquid handlers, automated extraction systems, and more. HTGC also provides clinical-grade sequencing.