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Binding affinity measurement is an important test item related to proteolysis targeting chimera (Protac®) technology. As a professional technical service company in the field of drug discovery and research, BOC Sciences provides outsourcing services for binding affinity testing. Our technical team has many years of experience in binding affinity measurement to ensure the accuracy and repeatability of the test.

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• 4 years ago - submitted by Marina Barrow

Targeted protein degradation provides a broad prospect for drug discovery. In addition, they pose many challenges, not only the ability to find conjugates and suitable drug-like properties for PROTAC methods, but also the need to transcend chance to select E3 ligase as a template for drug discovery. Once the compound is designed and synthesized, it will follow a series of in vitro evaluation analyses from drug administration to intracellular target degradation to verify the effectiveness of Protacs in the drug development phase prior to clinical trials. BOC Sciences can provide a comprehensive set of in vitro evaluation analysis to monitor the specific parameters of each stage. As a leading service provider in the field of drug discovery and research, BOC Sciences is fully competent and dedicated to serving one-stop Proteolysis Targeting Chimeric (PROTAC®) based molecular drug discovery which has become a promising strategy in the area of drug discovery. With a comprehensive and advanced platform, we provides PROTAC In Vitro Evaluation service to customers around the world to meet new drug discovery goals.

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• 4 years ago - submitted by Marina Barrow

Private Ivy League research university in Philadelphia, Pennsylvania. University, established as College of Philadelphia in 1740, is one of the nine colonial colleges chartered before the U.S. Declaration of Independence.

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• 4 years ago - submitted by Edyta Vieth

A plugin to estimate chromosome sizes from karyotype images.BSD 3-Clause "New" or "Revised" License. A plugin to estimate chromosome sizes from karyotype images.

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• 4 years ago - submitted by Edyta Vieth

Mouse anti-CaMKIIα，Millipore，Cat#C265

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• 4 years ago - submitted by ronghao mu

Profiling and controlling impurities level and their side pharmaceutical effects is crucial in both drug development and manufacturing process as they may affect the efficacy and safety of APIs, and then lead to failure in developing a potential drug or meeting the quality standard in production. BOC Sciences manufactures thousands of pharmaceutical impurities, degradations, metabolites of active pharmaceutical ingredients, and excipients in accordance with the guidelines and limits described in the international pharmacopeia monographs for many impurities to serve drug development. In particular, BOC Sciences has access to rarely found degradations preparation standards for a number of OTC pharmaceuticals, which enables us to manufacture many degradations with ease; and occasionally we share the standards with our clients all over the world.

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• 4 years ago - submitted by Krystal Beily

BOC Sciences has directed sincere efforts toward providing customers with high quality small-molecule inhibitors (inhibitors, agonists and modulators) with optimal prices. Most of our products can be supplied ranging from milligrams to kilograms scale and arrived with analytic report. Small-molecule inhibitors are a well-established class of potential useful drugs. Our products are included in all kinds of fields of Medical and Pharmaceutical research, such as Neurological Disease, Cancer, Metabolic Disease and so on.

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• 4 years ago - submitted by Krystal Beily

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• 4 years ago - submitted by Krystal Beily

Trifluoroacetyl Tripeptide-2 is a synthetic tripeptide, designed as a matrix metalloproteinase and elastase inhibitor. It can decrease progerin synthesis, increase proteoglycan production, and contract collagens. Trifluoroacetyl Tripeptide-2 regulates biological mechanisms involved in the aging process, reduces signs of aging including sagging, slacking, and wrinkles, and improves the skin firmness and elasticity.

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• 4 years ago - submitted by Caroline Miller

Dipeptide Diaminobutyroyl Benzylamide Diacetate, categorized as a neuro-peptide, is believed to block the body's uptake of Na+, which in turn causes the facial muscles to relax and prevent the formation of expression lines (wrinkles). Dipeptide Diaminobutyroyl Benzylamide Diacetate, as a safer alternative to botox, is mostly used in anti-aging products to inhibite muscle contractions and reduce wrinkles.

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• 4 years ago - submitted by Caroline Miller

Peptide lead optimization is to improve upon a lead molecule that demonstrates activity at a target of interest by optimizing its potency or selectivity at the target and its absorption, distribution, metabolism and elimination (ADME) properties. For successful peptide lead optimization, access to a reliable in vitro assay system is of utmost importance. This allows for precise SAR evaluations based on the binding affinity of peptide analogs to the target protein.

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• 4 years ago - submitted by Caroline Miller

Creative Peptides is able to provide a wide range of bioactive cosmetic peptides and also advisory services regarding cosmetic formulation. We will always endeavor to offer you the BEST QUALITY peptides. We can offer research- and GMP-grade cosmetic peptides according to your exact specifications. Please check our list of some of the most popular cosmetic peptides standing by. If you have a different cosmetic peptide synthesis requirement in mind, please let us know the peptide sequence, purity level required, and quantity needed. Our sales team will quickly generate a quote for you with price and delivery time.

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• 4 years ago - submitted by Caroline Miller

Palmitoyl Tripeptide-38 is the reaction product of palmitic acid and Tripeptide-38. It penetrates deep into the dermis to boost the production of collagen and the synthesis of hyaluronic acid, particularly on the forehead. It can be used as a cosmetic peptide, skincare, and made up designed to fight wrinkles.

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• 4 years ago - submitted by Caroline Miller

Peptide drug refers to a peptide having a specific therapeutic effect extracted by chemical synthesis, genetic recombination or animal or plant, and is a specific application of the peptide in the field of medicine. The biological activity of the peptide is extensive and important, and it can be widely applied to the endocrine system, the immune system, the digestive system, the cardiovascular system, the blood system, the musculoskeletal system, etc. With a team of experienced experts, advanced research equipment and proprietary methods, Creative Peptides provides a one-stop shop services for your early peptide drug discovery and accelerates your drug development process. The combination of our proprietary surface plasmon resonance (SPR) service and MHC-peptides tetramer service, diverse peptide libraries and arrays also provide an important channel for your peptide screening.

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• 4 years ago - submitted by Caroline Miller

this is a test

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• 4 years ago - submitted by Anita Bandrowski

Background: Storage pests cause extensive damages to stored products and are responsible for huge post-harvest losses affecting the quality, the quantity, and the germination potential of stored grains and seeds. This study aimed to investigate the variability of traditional methods of storage and conservation of maize seeds practised by farmers to propose alternative measures for a significant reduction of post-harvest losses of seeds. Methods : Using participatory research approaches, we surveyed farmers from 21 randomly selected villages in 5 districts in southern Benin. Data were collected on the storage structures of the 3 certified and most produced maize seeds varieties. The forms under which maize seeds are stored, as well as the damage caused by the major storage insects were determined. Results: Results showed that most farmers store maize seeds in the form of grains and spathe. Following the laboratory observation of the three maize varieties studied, the DMR / QPM variety produced only in the district of Zagnanado has a low abundance of storage insects and a low rate of post-harvest losses. Sitophilus zeamais is the most abundant pest of the three maize seed varieties followed by Prostephanus truncatus. The variety 2000 SYN EE was the most attacked by storage insects. The most promising post-harvest agricultural practice is the storage of maize with spathe saved in jute bags, in granaries or cribs. Conclusions: Storage insects contribute to the depreciation of the quality of grains, loss of grain and reduction of their germinability in stock. Improving farmers awareness of these post-harvest practices could help to reduce the damage of storage insects.

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• 4 years ago - submitted by Rodrigue Idohou

The codebase for the doctoral thesis titled: Improving force values for the unfolding thresholds of talin’s rod subdomains through force-domain simulations designed for the spatial and temporal ranges of talin.

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• 4 years ago - submitted by Guy Butcher

In addition to the isolation and cultivation of pure strains, adequate preservation is also necessary. A wide variety of techniques are available for bacteria preservation. The primary aim of cultural preservation is to maintain the organism alive, uncontaminated, and without variation or mutation, that is, to preserve the culture in a condition that is as close as possible to the original isolate.

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• 4 years ago - submitted by Jon Matthews

Microorganisms can be categorized in several ways including aerobes (require oxygen to survive), facultative anaerobes (able to use oxygen for aerobic respiration but may also use fermentation or anaerobic respiration when oxygen is not present, or use fermentation in the presence of oxygen), or obligate anaerobes (cannot survive in the presence of oxygen). Some examples of facultatively anaerobic bacteria are Staphylococcus spp., Escherichia coli, Salmonella, Listeria spp., Shewanella oneidensis, and Yersinia pestis. Certain eukaryotes are also facultative anaerobes, including fungi such as Saccharomyces cerevisiae and many aquatic invertebrates such as nereid polychaetes. Culturing facultative anaerobes, however, poses a challenge for researchers because the equipment to grow, isolate, and identify them can be costly.

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• 4 years ago - submitted by Jon Matthews

Atmospheric condition is generally satisfactory for the culture of aerobes or facultative anaerobes but for the growth of many aerobes, it is necessary to provide extensive aeration. Forced aeration of cultures is therefore frequently desirable and can be achieved either by vigorously shaking the flask or tube on a shaker or by bubbling sterilized air into the medium. When aerobic organisms are to be grown in large quantities, it is advantageous to increase the exposure of the medium to the atmosphere. This can be accomplished by dispensing the medium in shallow layers or by providing aeration by constantly shaking the inoculated liquid cultures.

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• SciCrunch
• 4 years ago - submitted by Jon Matthews