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Core offers light microscopy and imaging services. Provides access to and training on various confocal microscopes.
Software nuclei instance segmentation and classification framework based on hybrid task cascade.
National Cancer Institute (NCI)-sponsored randomized, controlled study (1993–2001) of ~155,000 adults aged 55-74 to evaluated whether organized, regular screenings could reduce cancer deaths compared to usual care. Portal provides randomized, controlled trial data used to determine whether certain screening exams reduce mortality from prostate, lung, colorectal and ovarian cancer.
Open-source foundation model for histology. Vision transformer model trained on haematoxylin and eosin stained tissue whole slide histology images. AI foundation model for pathology, developed by French startup Bioptimus. Launched as one of the largest open-source models for digital pathology, it is trained on histopathology slides for tasks like tissue classification, mutation prediction, and cancer subtyping.
Software tool for processing Epi-Proteomics mass spectrometry data. Discriminates isobaric histone peptides using distinguishing fragment ions in their tandem mass spectra and extracts the chromatographic area under the curve using previous knowledge about peptide retention time. Nanoflow liquid chromatography coupled with high resolution tandem mass spectrometry-based quantification tool for histone peptides, which can also be adapted to analyze nonhistone protein samples. EpiProfile 2.0 is extended version of v1.0 for enhanced quantification of histone peptides based on LC-MS/MS analysis.
Software tool to reverse-engineer transcriptional regulatory networks from co-expressed gene sets by identifying master transcription factors (TFs) and their direct target genes. It operates by scanning for enriched TF binding motifs in promoter regions, utilizing over 10,000 position weight matrices (PWMs) for human, mouse, and Drosophila. Used to enable gene regulatory network mapping directly based on motif enrichment in co-expressed gene set.
Core supports fundamental, translational, and clinical research by providing advanced services and expertise in cytometry, photonic microscopy, mass imaging, in vivo imaging, and bioinformatics. The cytometry and mass imaging unit offers flow, spectral and mass cytometry, cell sorting, multiplex panel development, and high‑dimensional data analysis. Photonic microscopy unit provides comprehensive support from sample preparation to image processing, with access to widefield, confocal, multiphoton and super‑resolution systems, and benefits from national recognition through IBISA and France BioImaging labels. The platform also hosts clinical transfer imaging activities (SP2I), developing optical tools for surgery and pathology in close collaboration with clinicians, with numerous funded projects and industrial partnerships. Request for citation from this core facility is to use the full name (synonym in this record) and address of the core: "Université Paris-Saclay, Gustave Roussy, INSERM, Analyse moléculaire, modélisation et imagerie de la maladie cancéreuse, F-94805 Villejuif, France, Plateforme d'Imagerie et Cytometrie PFIC (RRID:SCR_028222)"
Gustave Roussy is Europe’s leading comprehensive cancer center, located in Villejuif near Paris, France. It is a premier institution dedicated entirely to cancer treatment, research, and teaching, often ranked among the top oncology hospitals worldwide. Founded in 1925, it specializes in personalized medicine, rare cancers, and complex tumors.
Tokyo Chemical Industry Co., Ltd. (TCI) is a leading global manufacturer of specialty organic chemicals, founded in 1946. They produce over 30,000 research chemicals, including laboratory chemicals, reagents, and functional materials. TCI also acts as a supplier, offering custom synthesis and bulk production from milligrams to tons.
Image acquisition system to capture of chemiluminescence and fluorescence images. Using cooled CCD technology in combination with motorised optical lens, Fusion FX7 offers very high sensitivity and extended dynamic range. Data produced are directly compatible with image analysis software developed by VILBER and 1D image can be transformed into 3D results with Bio-1D and the Bio-Gene software.
Neuroanatomy-anchored Information Management Platform for collaborative BICAN data generation developed by UTHealth Houston. Serves as metadata tracking engine to support generation, management, and sharing of brain research data. Integrates data production pipelines across brain banks, laboratories, sequencing centers, and data archives. Platform enables integrative and collaborative, consortium-scale FAIR data generation within the BICAN project. Platform is designed to manage complex dataset, including tissue samples and sequencing data, through Specimen Portal and Sequence Library Portal. Portals provide multiple types of data interfaces through dashboards, APIs, faceted queries, and batch data ingestion and exporting.
Web tool to search life science articles with AI you can verify and control. Life science search engine designed to hit the sweet spot between classical search and AI-assisted research.
Core offers tools to precisely modify the genome of cells and organisms using CRISPR-Cas9-based editing, CRISPR interference (CRISPRi), and CRISPR activation (CRISPRa) systems. Our platforms enable high-throughput genetic screening, gene knockouts, transcriptional modulation, and sequence editing with high efficiency and scalability.
Core provides infrastructure and analytic support for population-based cancer research at UPMC Hillman Cancer Center. PANDA helps investigators access, manage, link, and analyze population-based cancer datasets to study cancer surveillance, treatment access, and survival in western Pennsylvania and across the United States using datasets such as SEER-Medicare, the Pennsylvania Cancer Registry (PACR), Pennsylvania Health Care Cost Containment Council (PHC4) hospital discharge data, the National Cancer Database (NCDB), and the UPMC Network Cancer Registry, along with area-level and geospatial data relevant to the Hillman catchment area.PANDA provides consultation on study design and data selection, assistance with data management and linkage, analytic dataset creation, population-level and geospatial analyses, and support for manuscripts and grant applications.
Premier Canadian academic medical research center located in Toronto, affiliated with the University of Toronto and Sunnybrook Health Sciences Centre focusing on translating scientific discoveries into clinical practice, with specialties in medical imaging, biology, and clinical trials.
Core offers services including cell sorting,cell analysis, user training for the flow cytometer benchtop analyzers, user training for the widefield and confocal microscopes.
Filmetrics F20 is a versatile, benchtop thin-film measurement system designed to measure the thickness, refractive index, and extinction coefficient of thin films. Using spectral reflectance in less than a second, it measures single or multi-layer stacks.
Advanced, stylus-based surface profiler used for high-precision, 2D and 3D surface topography measurements, including step height, surface roughness, and waviness. System measures roughness in the nanometer range. It provides a step-height repeatability of 5Å. It uses a diamond-tip stylus to physically trace samples, offering sub-nanometer vertical resolution and high repeatability.
A high-speed confocal microscope for 3D imaging of live or fixed biological samples, offering multi-wavelength laser excitation and high-resolution imaging capabilities.
A high-resolution TEM providing imaging, diffraction, and spectroscopic analysis at the atomic scale, suitable for materials science and nanotechnology applications.