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Provides services related to biospecimen procurement, banking, processing, and distribution. Housed biospecimen collections are from biorepositories of National Cancer Institute funded Children’s Oncology Group, NRG Oncology-Columbus (formerly the GOG Tissue Bank), SWOG, Pediatric Division of Cooperative Human Tissue Network, and Biospecimen Core Resource of Center for Cancer Genomics, as well as numerous biospecimen collections sponsored by funded NCH investigators. Cooperative Human Tissue Network is one of six institutions funded by National Cancer Institutes to access to remnant human tissues for biomedical researchers throughout the United States and Canada. Offers expertise in tissue preparation and preservation to meet the research needs of basic and applied scientists.
Shared analytical facility specialized in areas of radiogenic isotope geochemistry, non-traditional stable isotope geochemistry, and low blank concentration determinations of natural and engineered materials. Provided equipment includes triple-quad ICP-MS (Agilent 8900) with laser ablation intake system (AS RESOlution laser system), multi-collector ICP-MS (Neptune XT), and specially designed Picotrace metal-free low particulate clean laboratory. Produces high quality isotopic and trace element data. Offers training.
Provides guidance, access, and hands-on training for rock preparation, equipment uses, and mineral separation techniques. The most common uses are Powdering samples for geochemical or isotopic analysis;Cutting/drilling/coring rocks for geophysical analysis or generating thin section billets;Separation of zircon and apatite from quartz and feldspar;Soil and/or sediment sieving.
Provides microscopy expertise and access to high resolution, state-of-the-art imaging technologies to Stanford University and surrounding academic and biotech researchers. Core provides training, design, implementation, and analysis assistance.
Facility is equipped with JEOL JXA-8230 SuperProbe electron microprobe. Electron microprobe measures elemental compositions of solid samples by detecting the X-rays emitted on excitation by focused electron beam, down to spatial resolution of about 1 micron. All elements heavier than beryllium can be detected, at concentrations as low as 10s of ppm. Highly quantitative analyses are made using 5 wavelength dispersive X-ray spectrometers (WDS) with calibrations based on known standard materials. Compositional images (maps) can readily be obtained with backscattered electrons (sensitive primarily to mean atomic number), or with WDS or EDS X-ray data. The instrument is adjacent to the Stanford Nanocharacterization Laboratory (SNL), at the west end of the first floor of the McCullough Building.
Provides instruments for solid, aquouse and gas sample analyses, quantitative analysis, technical expertise to members of Stanford community.
Provides preclinical Magnetic Resonance Imaging technology and expertise to Stanford community. Offers range of support from full project to independent user operation and training.
Stable Isotope Biogeochemistry Laboratory at Stanford University's School of Earth Sciences provides analytical facilities and technical expertise to members of Stanford community who need to determine stable isotope ratios of variety of organic and inorganic materials from both terrestrial and marine environments.
Core for comprehensive examination of evolution of Earth's crust using geochronologic approaches. Provides spectrum of analytical facilities that are all housed within School of Earth, Energy and Environmental Sciences.Provides data to many disciplines throughout geosciences, including tectonics, geodynamics, petrology, geochemistry, geomorphology, sedimentology, stratigraphy, paleontology, and paleoclimatology.
Used to explore new visualization technologies related to study of brain.Provides equipment and expertiese to help with project setup and planning. Hosts adaptive optics system that uses optical principles originally developed for visualizing distant stars to enable high resolution imaging of retina in human subjects.
Core centralizes process of producing and distributing viral vectors and cDNA plasmids.
Laboratory at Wu Tsai Neursciences Institute provides preclinical discovery platform for central nervous system target validation in preclinical in vivo and in vitro models. Neurobehavioral assessment tools in CNS disease models provide platform for screening and profiling of experimental therapeutics and genetic rodent models. Used to support understanding of human CNS disorders and development of therapeutic interventions.
Provides space and equipment for collaborative pilot projects between engineers and neuroscientists, workshops, training classes and product demonstrations as requested by members of Wu Tsai Neuro. Facility provides tissue culture suite with two biosafety cabinets, CO2 incubators, centrifuge and fluorescent microscope, in vivo procedure suite to allow animal surgeries, four curtained electrophysiological rig/microscope areas, two microscope rooms, -20C and -80C freezers and 4C cabinets for temporary sample storage.
Core assists with production, characterization and differentiation of human pluripotent stem cells. Offers services related to research on human ES and iPS cells. Provides reprogramming of iPS cell lines from patients and healthy donors, for example for in vitro disease modeling. Offers already established human ES cell lines and large bank of human iPS cell lines established through ongoing REK-approved projects. Provides ES and iPS cell characterization services, and training in the culture and maintenance of human ES and iPS cells.
Provides services to conduct basic as well as translational research using human induced pluripotent cells. Offers Reprogramming, Genome editing and directed cell differentiation.
Provides germ free and gnotobiotic mice, space in which investigators can complete their own studies or hire core to complete experimental manipulations.Facility includes 12 large soft sided vinyl isolators for breeding and 8 small soft sided vinyl isolators for experiments. There is option between using Allentown positive pressure racks and static cage for experimental use.
Provides services for multiple modern NMR applications, including structure elucidation of small molecules, triple resonance experiments of biomolecules, fragment-based drug discovery, metabolomic and tissue analyses.
Provides support with technologies for cell and animal model needs. Services are ranging from CRISPR reagents with or without validation, to cancer/iPS cell line modification or animal model creation. Works closely with mouse cores from design, reagent validation to genotyping, process improvement and troubleshooting, when necessary. Provides next-generation sequencing (NGS) based human cell authentication and NGS-based genotyping services and general molecular biology assistance. Offers to culture, bank and store primary fibroblasts and renal epithelial cells from patient samples for investigators, and iPSC reprogramming service is provided from fibroblasts, RECs as well as peripheral blood mononuclear cells. Provides differentiation services on growing list of cell types.
Software R package as collection of functions that assist with streamline modeling. Works with binary or ordinal regression models, Cox regression, accelerated failure time models, ordinary linear models, Buckley-James model, generalized least squares for serially or spatially correlated observations, generalized linear models, and quantile regression.
SoftwareR package that identifies microbial taxa correlated with factors of interest using generalized linear models and mixed models.Used for efficiently determining multivariable association between clinical metadata and microbial meta'omic features.