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Provides access and training to instruments including optical microscopes with three confocal systems, two wide-field systems, light sheet system, laser-microdissection system, cell-culture microscope, stereomicroscope, optical tweezer system, and Atomic Force Microscope. Maintains cell culture equipment such as biosafety cabinet, incubators, refrigerator, and microfuges and lab support areas for cell culture and sample preparation.
Software pipeline developed in collaboration with BRAIN Initiative Cell Census Network and BRAIN Initiative Cell Atlas Network. Supports processing of spatial transcriptomic data generated with Slide-seq commercialized as Curio Seeker assay.
THIS RESOURCE IS NO LONGER IN SERVICE. Documented on December 5,2025. Core provided services include paraffin embedding, paraffin and cryo sectioning, histological stainings, immunostainings; Image acquisition includes brightfield, fluorescence and polarized light whole slide imaging,2D fluorescence microscopy, 3D fluorescence microscopy; Image analysis includes 2D images : ImageJ/Fiji support – ZEN Analysis (Zeiss),2D whole slide scans: Author (Visiopharm), Halo (Indicalab), QuPath, 3D images: Arivis (Zeiss), Imaris (Bitplane).
Proteomics Unit is joint effort of Universitat Pompeu Fabra and Center of Genomic Regulation. Provides proteomics services by offering state-of-the-art methods, advise and expertise to support basic and translational researchers; developing new methods and techniques that keep the unit up to date and at the forefront of the proteomics field; training community and actively disseminating proteomics science and methods.Part of Spanish National Infrastructure for Omics Technologies and European Proteomics Infrastructure Consortium, and it coordinates European innovative and interdisciplinary Research and Training network. The Proteomics Unit is also part of Spanish National Health System.
Provides technology platform to perform protein production and automated processes in context of biomolecular and biochemical screening assays.Through staff assisted screening, users have access to equipment including liquid handlers, plate readers and small molecule libraries.Unit is aimed at supporting the researchers of the CRG institute by purchasing, seeking and maintaining valuable stocks of clones and strains.
Provides latests technologies for stem cell biology, stem cell differentiation, organoid formation and induced pluripotent stem cells.Tissue Engineering platform works in collaboration with Biomolecular Screening and Protein Technologies Unit to provide CRISPR/Cas9 genome editing technology service.Unit also includes Histology In-house Service (only for PRBB residents) provides histopathological analysis required for analysing tissues from research performed in in vivo models. Histology In-house Service performs and optimizes histological processing and analysis of tissue, from experimental animal models and human origin.Provides mentoring and training in common histological techniques.
Supports next generation sequencing technologies and provides several next generation sequencing instruments. Several high-throughput technologies have been implemented to assess differential expression, inter-individual genetic variation, microRNA discovery, genome sequencing, targeted resequencing, epigenetic profiling and identification of binding sites of DNA or RNA-associated proteins.
Provides services of consultation, planning NGS and other genomic experiments, NGS data processing, analysis and management, software and database development, bioinformatics training, and access to high-performance computing resources at CRG. The Unit works in synergy with the Genomics Unit and the Biomolecular Screening and Protein Technologies Unit to support users using high throughput sequencing technologies from experiment planning to delivery of timely and reliable results.
Flow cytometry studies optical parameters emitted by particles (cells, cell fractions). Flow cytometers can study a series of parameters of individual particles simultaneously, quickly and on a large number of individualized particles in suspension. Flow cytometers use lasers as a source of light excitement; therefore, it must be possible to mark the particles with one or more fluorescent substances. Information is also collected regarding the size and structural complexity of each particle. This multiparameter study of each particle enables us to analyse subpopulations in complex samples through electronic sorting. Some cytometers are also equipped with sorting and collection modules for particles of interest. The most important applications of flow cytometry include those relating to the study of cell surface receptors, nuclear and cytoplasmic antigens, DNA content, enzyme activity, cell integrity and membrane permeability and calcium flows. The Unit currently hosts five analyzers and two sorters, and is therewith the largest Becton Dickinson site in Spain. The sorters are operated by the facility personnel, who also support the users in experimental design and data analysis. The analyzers are operated by the users themselves, after they have been trained. The facility personnel helps with the experimental design and supervises and monitors the experiments when necessary.
Core provides support with experimental design, sample preparation, acquisition, bioimage analysis and visualization.Consists of microscope systems specifically designed for fluorescence microscopy ranging from confocal, widefield to super resolution systems and helps reveal structures from macro to nanoscale.
Provides equipment and expertise for analysis of variety of biological and small molecules.Services include protein analysis encompassing protein identification, protein and peptide sequence confirmation, intact protein molecular weight determination, complex protein sample analysis, and protein/antibody drug interactions.Developed metabolomics library to support metabolomic and lipidomics analysis. Can identify range of post-translational modifications, determining their presence or absence, as well as quantitating PTMs.Proteomics and small molecule services include workflows for label free,chemical labeling (iTRAQ/TMT) and metabolic labeling (SILAC).Service for molecular synthesis, with monitoring reaction steps,calculating percentage of product, testing for purity, and molecule characterization with high resolution and high mass accuracy.Provides molecular weight and chemical composition determinations, structure elucidations and compound identification analysis or confirmation and accurate mass measurements of synthetic products, measurement of polymers, nucleic acids (DNA/RNA), peptides, proteins, natural products, and assistance with determination of unknowns.
Software VH Lab tools for analysis of calcium imaging data. Allows selection of ROIs and extraction of time series data from raster-scanned, line-scanned, or CCD images, written in Matlab.
Software tool as platform independent data interface and database for neuroscience physiology and imaging experiments. Platform independent standard that allows analyst to use and create software that functions independently from format of raw data or manner in which data are organized into files. Interface is rooted in simple vocabulary that describes common apparatus and storage devices used in neuroscience experiments. Results of analyses, and analyses of analyses, are stored as documents in scalable, queryable database that stores relationships and history among experiment elements and documents. Interface allows development of application ecosystem where applications can focus on calculation rather than data format or organization. This tool can be used by individual labs to exchange and analyze data, and it can serve to curate neuroscience data for searchable archives.
Open source software analysis tool to investigate space plasma turbulence and nonlinear DYNamics. Wraps comprehensive set of advanced data analysis methods meant to facilitate study of turbulence, nonlinear dynamics, and complexity in space plasmas.
Software package focused on automated delineation of major fiber tracts in individual human brains, and quantification of tissue properties within the tracts.Software for automated processing and analysis of diffusion MRI data. Automates tractometry.
Software suite of automation tools, purpose-built to speed up multiple steps in systematic review process. Assist with many steps of systematic review, including searching for citations, citation screening and write-up of review findings, among others. Existing tools are being continuously reviewed and refined, and additional tools are being developed. Systematic Review Accelerator project is based at the Bond University Institute for Evidence-Based Healthcare.
HTAN is National Cancer Institute funded Cancer Moonshot initiative to construct 3-dimensional atlases of dynamic cellular, morphological, and molecular features of human cancers as they evolve from precancerous lesions to advanced disease.Provides three dimensional atlases of cancer transitions for diverse set of tumor types. Efforts to map healthy organs and previous large-scale cancer genomics approaches focused on bulk sequencing at single point in time. Data portal for Human Tumor Atlas Network. Data available on HTAN Portal is open access. Certain data types with potential for re-identification are available in restricted access through dbGAP.
Software critical appraisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both.Measurement tool to assess systematic reviews.
Research assistant using language models like GPT-3 to automate parts of researchers’ workflows. Main workflow is Literature Review. If you ask question, Elicit will show relevant papers and summaries of key information about those papers in easy-to-use table.
Productivity and collaboration PDF solution, combining Acrobat desktop software, mobile scan app, signature app and Acrobat Reader mobile app enhanced with premium mobile features and premium Document Cloud services.