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Core provides instrumentation and service for the University of Wyoming scientific research community. Services include X-ray, Electron Microscopy, and Light microscopy analysis.
Software package for atomic model refinement and map calculation. Software for structure refinement and validation for crystallography and single particle analysis.
Software tool for filtering and trimming next generation sequencing reads.
Biosensor system designed for rapid, automated analysis of biomolecular interactions. It excels in characterizing and screening small molecule drug candidates and antibody interactions with high sensitivity, offering rapid fragment screening and affinity determination. Detects low molecular weight (LMW) compounds and weak binding interactions. Optimized for rapid screening of libraries with automated data evaluation for up to 384-well plates. Measures binding interactions in real-time without labeling.
Core provides integrated, end-to-end support for molecular biology and genomics research. Services include DNA/RNA extraction, sample quality control, genotyping, qPCR/ddPCR, and next-generation sequencing using Illumina and Oxford Nanopore platforms. In addition to laboratory services, MBGC offers consultation, experimental design guidance, troubleshooting, and training to support high-quality and reproducible research outcomes.
Core offers histological and immunohistochemical services.Our staff includes ASCP certified Histologists and American Board of Pathology certified Pathologists who provide service, assistance, and quality control. Provided services include grossing specimens, frozen and fixed tissue sectioning, routine H&E and specialized histochemical staining, cytospin preparations, IHC/IF and antibody optimizations using investigator provided antibodies. Provides training for immunohistochemical and histochemical techniques.
Core provides investigators in the Western New York area with genetically modified animals for their research through gene targeting and transgenic methodologies.
Core brings together UTM’s Growth Facilities, Imaging Facility, Life Sciences Facilities, and NMR Centre into a unified ecosystem that supports academic researchers with shared tools, expert support, and hands‑on training. Provided services include design of multi-scale experimental workflows,cross-platform training,coordinated sample preparation across scales,seamless facility operations,facilitation of data integration, and troubleshooting.
Core provides high throughput microbiology screening services and high-end mass spectrometry for diverse range of molecules.
Software toolkit for inspection, validation, repair, and reproducible processing of neuronal morphology reconstructions stored in SWC format. It provides a desktop GUI, a command-line interface, and a Python API for issue-driven curation, automated neurite labeling, radii cleaning, simplification, geometry editing, batch processing, and structured reporting.
Core provides guided access to novel technologies for complete dissection of energy flux in rodents and other small animals. Our expert staff assist in development, testing, and standardization of metabolic technologies and workflows to leverage both mouse and rat models of interest. Facility offers 16-cage multiplexed metabolic phenotyping system (Promethion, Sable Systems International) that provides detailed mechanistic dissection of resting metabolic rate (RMR), physical activity, and ingestive behaviors of rodents in home style cage designs across the light cycle. CRMPC combines RMR assessments with direct/combined calorimetry (total heat dissipation) to enable assessment of anaerobic forms of energy expenditure (gut microbiome). Additional services include body composition analysis (via NMR), bone content and density analysis (via DEXA), metabolic caging, indirect calorimetry, bioimpedance spectroscopy, thermal imaging. Staff provide guidance for experimental design, execution of studies, statistical analysis of resulting data, and regulatory assistance and compliance.
Flow cytometer designed for comprehensive, high-parameter analysis of heterogeneous cell populations. It utilizes spectral technology supporting up to 7 lasers and 186 detectors to detect dim/rare populations and distinguish over 44 colors, making it ideal for advanced immunology and oncology research.
High-performance, multicolor flow cytometer used to analyze and isolate (sort) specific cell populations with high precision, measuring up to 50–60 parameters. Offers 6-way sorting, indexing for single-cell sorting (e.g., RNA-seq), and BSL-2 biosafety containment.
Flow cytometer that combines real-time imaging with spectral flow cytometry. Enables researchers to analyze cell morphology, protein location, and molecular characteristics simultaneously at high speeds, offering deeper single-cell insights than traditional flow cytometry.
Core offers custom peptide services. Facility provides expertise and instrumentation dedicated to chemical synthesis, purification, and characterization of peptides and peptide materials. Provides standard and catalog peptides, and synthesis of specialty custom peptides modified to fit specific research needs.
Core offers confocal imaging systems for specialized imaging of neuronal tissue, including AxL Cleared Tissue Light Sheet Microscope along with appropriate software including Bitplane Imaris 10.0 F1 package and SVI Huygens Professional deconvolution software. The availability of a cleared tissue instrument enables unparalleled visualization of developmental processes, injury recovery, and disease-related pathology.
Imaging core houses microscopic imaging systems including several confocal microscopes, laser microdissection system and whole slide scanners. Core users will be trained and consulted on instrumentation, software, and analysis.
Core offers services for identification, quantification, and structural characterisation of proteins using next–generation mass spectrometry platforms. Uses mass spectrometry platforms that include Orbitrap Lumos, Ascend and Astral Zoom systems. Services include designing of experimental strategies, implementing and validating previously developed proteomic workflows to profile proteins from diverse biological samples, as well as developing methods and assays when required. Core focuses and specializes in using stable isotopic labelling strategies (Tandem Mass Tags) as well as label-free methods using different acquisition methods (DDA and DIA) for relative quantification of protein expression levels and enrichment within protein complexes. Develops and runs PRM (parallel reaction monitoring) assays for targeted quantification of defined panels of proteins.
Core offers workspaces and equipment for your histology techniques, as well as advice, training, and services.
Facility for trace-level analysis of anthropogenic organic chemicals in environmental and biological specimens.Specializes in mass spectrometry based analysis, including targeted and nontargeted methods. Capable of quantifying nearly all the organic analytes monitored by the Centers for Disease Control and Prevention (CDC) in the National Health and Nutrition Examination Survey (NHANES) program. Commonly assayed targets include phthalates, bisphenols, per- and polyfluoroalkyl substances (PFAS), glyphosate, organophosphate flame retardants, organophosphate pesticides, and other compound classes at biologically and environmentally relevant concentrations. Our nontargeted analysis workflows are capable of detecting hundreds to thousands of chemical features in a single sample, enabling the identification of unknown organic compounds without a priori target selection.Laboratory operates as a shared resource within NYU Langone's Division of Advanced Research Technologies (DART), which is part of the Office of Science and Research (OSR). We provide precise chemical analysis to support studies on environmental exposures and their health impacts.