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Web tool for analyzing, annotating and sharing multi-dimensional data. Visualisation platform used for spatial analysis.
Database offers integrated multi-omic data for patients across 33 cancer types. It encompasses gene expression, DNA methylation, somatic mutations, proteomic profiles, and chromatin accessibility, drawing from TCGA, GTEx, and CPTAC projects. Users can compare gene expression, DNA methylation, and protein levels between tumor and normal tissues, identifying differentially expressed genes and proteins, and examining gene-to-gene correlations. Provides oncogene mutation profiles and allows for survival analysis based on gene expression and methylation, linked to clinical parameters. Facilitates exploration of multi-omic correlations, such as gene expression with DNA methylation, and their variations with mutation status. Extends its analytical capabilities to include six major oncoviruses, offering insights into their impact on gene expression, methylation, and patient survival.
Web application made for plotting genomic data. Used for genomic composite visualization for bioinformaticians and bench scientists to visualize and analyze signal occupancy across genomic regions.
Automated instrument designed to extract, purify, and quantify nucleic acids (DNA/RNA) from diverse biological samples, preparing them for Next-Generation Sequencing (NGS). It accelerates laboratory workflows, allowing 20 minutes of hands-on time to yield NGS ready samples in ~2 hours.
MRI-based atlas package for the titi monkey brain that includes a single subject atlas (UC Davis Titi monkey Neuroimaging Atlas (UCD-TiNA)), alongside a population atlas (UCD-TiNA_group) and a manually segmented atlas compilation (UCD-TiNA_mac).
Project to compare two approaches for the construction of longitudinal predictive models, which were used here to estimate the conversion of mild cognitive impairment (MCI) to AD.
Public engineering school in Montreal, Canada, affiliated with the Université du Québec system. Founded in 1974, it specializes in applied engineering education and research, with a strong focus on cooperative education (mandatory internships), industry collaboration, and practical, hands-on training for bachelor, master, and doctorate students.
Core provides genomics services including next-generation sequencing, gene expression, and genotyping. It enables studies on human disease mechanisms, cancer, and rare diseases.
Core provides equipment for the fabrication and advanced characterization of cyber-physical microdevices, particularly printed cyber-physical microdevices. Provide students and researchers with environment where engineers receive training with advanced skills in the analog, digital and mixed domains.
Automated microscopy system for high-plex, subcellular spatial proteomics. System integrates automated microscope, fluidics unit for automated staining, and analysis software. It utilizes cyclic immunofluorescence with EpicIF technology to image, remove signals, and restain tissues to map proteins at single-cell resolution. System is developed by Canopy Biosciences, a Bruker Company, and is often used alongside AI-powered data analysis tools to classify cell phenotypes and visualize tissue architecture.
Software R package to enable rapid reference mapping and annotation of new scRNA-seq data across the spectrum of normal and malignant hematopoietic contexts. Single cell RNA-seq reference map of human hematopoietic development in the bone marrow, with balanced representation of hematopoietic stem and progenitor cells and differentiated populations.
Software tool for haplotype aware CNV analysis from single-cell RNA-seq, ATAC-seq, and multiome. Haplotype aware analysis of somatic copy number variations from single-cell transcriptomes. It integrates signals from gene expression, allelic ratio, and population-derived haplotype information to accurately infer allele-specific CNVs in single cells and reconstruct their lineage relationship.
Core offers services in the field of bulk, single cell, spatial omics, FACs sorting and sequencing.
Specialized, compact confocal laser scanning microscope designed for high-resolution 3D fluorescence imaging. Key features include 2048 x 2048 pixel resolution, a point-scan mechanism, and compatibility with Zeiss Zen software for 3D reconstruction and image processing.
High-resolution 3D X-ray microscope (micro-CT) designed for non-destructive, submicron imaging of internal structures in materials science, electronics, and life sciences. It allows researchers to visualize 3D details at 500 nm resolution without cutting samples, using "Resolution at a Distance" (RaaD™) technology to image large or complex items.
Core provides instrumentation, training, and high-level scientific and technical expertise relating to conventional and spectral cytometry, cell sorting, small particle analysis, ELISA/ELISpot, PBMC processing and cryopreservation, and multiplex assays.
Facility focused on next-generation sequencing services. Offers advanced capabilities in next-generation sequencing, single-cell sequencing, and genomics and epigenomics services.
Cancer genomics project management and data sharing support facility.
Core offers high-throughput sequencing, genotyping, single-cell multi-omics, and spatial biology services as well as training and consultation. Next Generation Sequencing (NGS) technologies including Illumina and Element Biosciences short-read sequencing, PacBio and Nanopore long-read sequencing services provide sequencing and library preparation for these platforms. Genotyping is performed on the Fluidigm EP1 System for low to medium assay numbers, genotyping-by-sequencing assays, and with a range of genotyping-by-sequencing technologies (e.g. multiplexed amplicon, single-primer extension, reduced representation, and skim-seq protocols). Gene expression analysis is carried out by RNA-seq on short-read sequencers as well as full-length transcript sequencing on long-read systems. Single-cell transcriptome (high-throughput single-cell gene expression profiling) and multi-ome studies are enabled by our 10X Genomics Chromium X system and Parse Biosciences assays. Spatial transcriptome profiling is supported on the Xenium and Visium HD platforms with the help of our CytAssist instrument for fresh-frozen, fixed-frozen, and FFPE tissue sections. We offer annual Illumina and PacBio sequencing library preparation workshops, free consultations on project considerations and experimental design, and custom sequencing library prep solutions.
Facility provides access to human stem cells, 3D organoids, and other human-relevant disease models to support more predictive drug discovery, improved safety and toxicity assessment, and deeper mechanistic insight. Leveraging organoid and microphysiological platforms, the core enables next-generation therapeutics and clinical trial-in-a-dish approaches that advance biomedical innovation and precision medicine.