Curator Dashboard

Core provides services for mouse genotyping and tissue histology, access to tools for analyzing cardiovascular function, data analysis, expertise and training. Services include genotyping using PCR or RT PCR, histology services with tissue processing, paraffin-embedding and sectioning, along with several cardiovascular relevant histological stains such as Picrosirius Red and Masson Trichrome.

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• SciCrunch
• 3 years ago - submitted by Edyta Vieth

Core provides access to research services, educational and training opportunities, and technologies including cellular metabolism, flow cytometry, fluorescence, confocal, super resolution confocal microscopy, next generation sequencing, and real-time PCR. Provides assistance with all aspects of these technologies, including experimental design, protocol optimization, instrument operation, and data analysis.

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• SciCrunch
• 3 years ago - submitted by Edyta Vieth

Web service for online data drawing and analysis, personalized data analysis, scientific research mapping, online page/database development and hosting. Used for high throughput sequencing data analysis including eccDNA-seq, MeRIP-seq, circRNA-seq, miRNA-seq, mRNA-seq, LncRNA-seq, piRNA-seq, ChIP-seq, etc.

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• RRID
• 3 years ago - by Anonymous

Software code package associated to the paper: Lemke et al. Information flow between motor cortex and striatum reverses during skill learning. 2023. Quantifies information theoretic quantities used in the associated study.

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• 3 years ago - submitted by Marco Celotto

Software application as MATLAB scripts to compute measures of Feature-specific Information Transfer (FIT) and conditional FIT (cFIT). FIT quantifies direction and magnitude of information flow about specific feature S (such as feature of sensory stimulus) between simultaneously recorded brain regions X and Y. cFIT quantifies amount of directed feature information transmitted between regions X and Y that cannot be potentially routed through region Z.

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• 3 years ago - submitted by Marco Celotto

Software finite element analysis package. Used to solve field problems.

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• 3 years ago - by Anonymous

ACTH ELISA kit to measure ACTH levels in human, mouse and rat plasma samples. ACTH (Adrenocorticotropic hormone) or corticotropin is a 39-amino acid hormone (MW=4500) secreted by the pituitary to regulate the production of steroid hormones by the adrenal cortex. ACTH secretion from the anterior pituitary is controlled by both a classical negative feedback control mechanism and CNS-stress mediated control system. Various types of stress or pain perceived in higher levels of the brain modulate secretion of the hypothalamic neurosecretory hormone, corticotropin releasing hormone (CRH), a 41-amino acid peptide. CRH stimulates pituitary ACTH secretion. The second peptide that modulates ACTH secretion is vasopressin (AVP). AVP secretion is also stimulated by stress and acts synergistically with CRH to increase ACTH secretion in the pituitary portal circulation. ACTH increases the synthesis and release of all adrenal steroids, aldosterone, cortisol and adrenal androgens. It is the principal modulator of cortisol, the most important glucocorticoid in man. As the cortisol level in blood increases, release of ACTH is inhibited directly at the pituitary level. Through this same mechanism, decreasing cortisol levels lead to elevated ACTH levels. Biologically active ACTH results from enzymatic cleavage of a large precursor molecule, pro-opiomelanocortin (POMC). This molecule contains within its structure the amino acid sequences of ACTH, Pro-ACTH, -melanocyte stimulating hormone, lipotropin, as well as endorphin and the enkephalins. Because the reaction in immunoassays is determined by antigenic structure, not biological function, the usual ACTH RIA reacts with POMC, Pro-ACTH, ACTH and some fragments of the ACTH. ACTH may also be referred to by the following terms: ACTH ELISA kit, Adrenocorticotropic Hormone ELISA kit, Adrenocorticotropin ELISA kit, Alpha-Melanocyte-Stimulating Hormone ELISA kit, Alpha-MSH ELISA kit, Beta-Endorphin ELISA kit, Beta-LPH ELISA kit, Beta-Melanocyte-Stimulating Hormone ELISA kit, Beta-MSH ELISA kit, CLIP ELISA kit, Corticotropin-like Intermediary Peptide ELISA kit, Corticotropin-Lipotropin ELISA kit, Corticotropin-Lipotropin ELISA kit, Gamma-LPH ELISA kit, Gamma-MSH ELISA kit, Lipotropin Beta ELISA kit, Lipotropin Gamma ELISA kit, LPH ELISA kit, Melanotropin Alpha ELISA kit, Melanotropin Beta ELISA kit, Melanotropin Gamma ELISA kit, Met-Enkephalin ELISA kit, MSH ELISA kit, NPP ELISA kit, POC ELISA kit, Pro-ACTH-endorphin ELISA kit, Pro-OpioMelanocortin ELISA kit, ProopioMelanocortin ELISA kit, ProopioMelanocortin PreProProtein ELISA kit

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• 3 years ago - submitted by Viktoria Fisi

The Metabolomics, Lipidomics, and Proteomics Platform facilitates metabolism-related and molecular research, serving researchers from academia and industry in Luxembourg and beyond. We specialize in the comprehensive analysis of small molecules and proteins within complex biological matrices. Our advanced analytical infrastructure and broad method portfolio accelerate scientific discoveries across biology, biomedicine, and systems biology.

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• SciCrunch
• 3 years ago - submitted by Edyta Vieth

Software tool that quantifies tumor content in cfDNA from 0.1× coverage whole-genome sequencing data without prior knowledge of tumor mutations. Used to simultaneously segment genome, predict large scale copy number alterations, and estimate tumor fraction of ultra low pass whole genome sequencing sample.

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• 3 years ago - by Anonymous

Software tool for annotating fusion transcripts, incorporated into Trinity Cancer Transcriptome Analysis Toolkit utilities, and leveraging databases including CTAT Human Fusion Lib.

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• 3 years ago - by Anonymous

Software application to estimate presence of MRD in plasma cfDNA WGS through evaluation of matched tumour-derived mutations (SNVs or CNVs).

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• 3 years ago - by Anonymous

Software tool for microsatellite instability detection using high throughput sequencing data. It accepts the whole genome sequencing, whole exome sequencing and target region sequencing data as input. Introduces multinomial distribution model to quantify polymerase slippages for each tumor sample and discriminative sites selection method to enable MSI detection without matched normal samples.

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• 3 years ago - by Anonymous

Open source platform to support management of educational audio and video content. Institutions can use Opencast to produce lecture recordings, manage existing video, serve designated distribution channels, and provide user interfaces to engage students with educational videos.

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• 3 years ago - submitted by Manuel Oellers

Core utilizes dual tube micro X-ray computed tomography scanner for imaging specimens in fields of paleontology, comparative anatomy, evolution and development, basic biomedical studies, and research in geology and material sciences.It is equipped with 180 kV nano-focus and high power 240 kV micro-focus CT tube. This setup allows to scan very small specimens with high resolution using nano tube or dense fossils using high power tube.

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• SciCrunch
• 3 years ago - by Anonymous

Core provides bioinformatics and statistics expertise. Core develops and maintains automated and customizable workflows for processing and analyzing many types of genomic data; supports design of rigorous, robust and reproducible experiments and proposals; assists in preparation of manuscripts, grants and presentations; and provides education and training in use of software and analysis methods.Core can contribute to many types of bioinformatics or statistical projects.

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• SciCrunch
• 3 years ago - submitted by Edyta Vieth

Core is part of the University of Manchester Faculty of Science and Engineering. Facility offers support and services in chemistry, biology and materials. Mass spectrometers including Orbitraps, Ion Mobility, MALDI, DESI, hyphenated LC-MS and GC-MS apparatuses. Other instruments are HPLC systems, UHPLC systems and GC systems.

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• 3 years ago - by Anonymous

Shared instrumentation facility at the American Museum of Natural History with tools for X-ray tomography, electron microscopy, confocal microscopy, light microscopy and image analysis. Provides expert assistance in the use of all lab equipment.

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• SciCrunch
• 3 years ago - by Anonymous

Software application to integrate scRNA-seq and scTCR-seq data to allow for more comprehensive analysis that leverages the strengths of both data types.Repository contains code and information of data used in the paper “scNAT: A deep learning method for integrating paired single cell RNA and T cell receptor sequencing profiles”. Source code for scNAT are in the scNAT folder, the tutorial is in the tutorials folder.

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• 3 years ago - by Anonymous

Software standardized pipeline for ATAC-seq data analysis with serial alignments. Leverages unique features of ATAC-seq data to optimize for speed and accuracy, and provides several unique analytical approaches. Downstream analysis is simplified by standard definition format, modularity of components, and metadata APIs in R and Python. Restartable, fault-tolerant, and can be run on local hardware, using any cluster resource manager, or in provided Linux containers. We also emphasize the advantage of aligning to the mitochondrial genome serially, which improves alignment and quality control metrics. Includes quality control plots, summary statistics, and variety of data formats.

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• 3 years ago - by Anonymous

Software pipeline for annotating predicted Nucleotide binding and leucine rich repeat genes from non-masked genome fasta file input.

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• 3 years ago - by Anonymous