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Facility provides imaging instrumentation and analysis software along with training and expertise.Instrumentation and technologies available to users include Zeiss LSM800 AIRYSCAN confocal microscope integrated with Zen software; PerkinElmer / Akoya Vectra 3.0 Automated Quantitative Pathology Imaging System;Agilent/BioTek Cytation 5 with BioSpa8 live-cell microscopy system for fluorescence and phase contrast microscopy; Olympus IX-83 ZDC2 microscope equipped with PRIMO UV light-based bioengineering device for micropatterning and microfabrication; Olympus IX73 Inverted Fluorescence Microscope.Image analysis software hosted on appropriately powered workstations with cloud connectivity for high capacity storage: HALO3, Inform, Volocity, AutoDeblur, Image-J / Fiji.Transmission and scanning electron microscopy including FEI Talos F200i (200kV TEM and STEM electron microscope (TEM), equipped for micro-analysis, and cryo-EM;FEI Helios CX5 dual beam FIB-SEM system with X-ray microanalysis detectors; instruments for specimen preparation for transmission and scanning electron microscopy including ultramicrotomes Leica Ultracut UC6 and UC7, critical point dryer Samdri-970, Leica ACE 600 coater and ThermoFisher Vitrobot.

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• SciCrunch
• 2 years ago - submitted by Edyta Vieth

Provides College of Medicine research community with access to atomic force microscopy equipment and expertise.

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• SciCrunch
• 2 years ago - submitted by Edyta Vieth

Genotype Sparse Compression (GSC) is an advanced tool for lossless compression of VCF files, designed to efficiently store and manage VCF files in a compressed format. It accepts VCF/BCF files as input and utilizes advanced compression techniques to significantly reduce storage requirements while ensuring fast query capabilities. In our study, we successfully compressed the VCF files from the 1000 Genomes Project (1000Gpip3), consisting of 2504 samples and 80 million variants, from an uncompressed VCF file of 803.70GB to approximately 1GB.

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• SciCrunch
• 2 years ago - submitted by Xiaolong Luo

Genotype Sparse Compression (GSC) is an advanced tool for lossless compression of VCF files, designed to efficiently store and manage VCF files in a compressed format. It accepts VCF/BCF files as input and utilizes advanced compression techniques to significantly reduce storage requirements while ensuring fast query capabilities. In our study, we successfully compressed the VCF files from the 1000 Genomes Project (1000Gpip3), consisting of 2504 samples and 80 million variants, from an uncompressed VCF file of 803.70GB to approximately 1GB.

• Resource
• SciCrunch
• 2 years ago - submitted by Xiaolong Luo

Genotype Sparse Compression (GSC) is an advanced tool for lossless compression of VCF files, designed to efficiently store and manage VCF files in a compressed format. It accepts VCF/BCF files as input and utilizes advanced compression techniques to significantly reduce storage requirements while ensuring fast query capabilities. In our study, we successfully compressed the VCF files from the 1000 Genomes Project (1000Gpip3), consisting of 2504 samples and 80 million variants, from an uncompressed VCF file of 803.70GB to approximately 1GB.

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• SciCrunch
• 2 years ago - submitted by Xiaolong Luo

Software tool for lossless compression of VCF files, designed to efficiently store and manage VCF files in compressed format. It accepts VCF/BCF files as input and utilizes advanced compression techniques to significantly reduce storage requirements while ensuring fast query capabilities.

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• SciCrunch
• 2 years ago - submitted by Xiaolong Luo

Fully automated, inverted, multi-channel fluorescence and transmitted light imaging system. System with acquisition tools with enhanced autofocus algorithms and automated routines for microwell plate assays, time-lapse live cell imaging, area scanning in time lapse and Z-stacks in scan mode to generate publication quality images and data.

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• RRID
• 2 years ago - by Anonymous

High sensitivity flow cytometry for nanoparticle analysis for life science, nanoscience and nanotechnology studies. Can be used for multiparameter characterization of natural and synthetic nanoparticles (7-1000 nm) at the single particle level.Combining light scattering and fluorescence detection, high-resolution distributions of particle size and biochemical properties can be acquired simultaneously in 1-2 minutes. UNL Flow Cytometry Core NanoAnalyzer is equipped with two lasers (488 and 640nm), and is capable of detecting SSC and two colors. Operates under NF Professional Software. System is designed to measure size and concentration of nanoparticle samples.

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• RRID
• 2 years ago - submitted by Dirk Anderson

Offers multiple configurations with the option to easily upgrade. Instrument can be configured to use up to four lasers and up to 15-color detection to identify subtle differences between cells. Core Facility’s CytoFLEX SRT is four-laser platform (405, 488, 561 and 638nm) instrument capable of detecting FSC, SSC and 15-colors and is able to sort up to four separate populations from the same sample, and deposit them in variety of tubes and plates. Operates under CytExpert SRT Software.

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• RRID
• 2 years ago - submitted by Dirk Anderson

This model is equipped with four lasers (405, 488 561 and 638nm), and is capable of detecting FSC, SSC and 16 colors.

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• RRID
• 2 years ago - submitted by Dirk Anderson

Software tool for analysis of non-covalent interactions in molecular dynamics trajectories. Implemented in Python and is universally applicable to any kind of MD trajectory supported by MDAnalysis package.

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• RRID
• 2 years ago - by Anonymous

PCR thermal cycler with 96 well block (12 8 x 0.2 mL strip tubes, 96 x 0.2 mL), AC/DC input 230 V AC.

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• RRID
• 2 years ago - by Anonymous

Automated pipetting workstation that is used for serial dilutions, reagent distribution, sample transfer from tubes to plates, and sample normalization.

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• RRID
• 2 years ago - by Anonymous

Biotechnology company in Nuaillé, France. Provides animal serum and cell culture media.

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• RRID
• 2 years ago - by Anonymous

Company offers research chemicals and biochemicals for scientific use. Provides customer oriented services including customized order volume ranging from milligrams to kilograms scale, structurally and synthetically diverse biologically active compounds.

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• RRID
• 2 years ago - by Anonymous

Software tool for predicting reservoir hosts of RNA viruses through viral genomes. Takes complete RNA viral genomes as input and predicts natural reservoir host groups from kingdom level to order level.

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• RRID
• 2 years ago - submitted by Guowei Chen

Cell culture medium

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• RRID
• 2 years ago - submitted by Zhiqun Tan

Software for processing and analyzing Targets and Tagmentation data. The illustration data used in this tutorial is the profiling of histone modifications in the human lymphoma K562 cell line, but the tutorial is generally applicable to any chromatin protein, including transcription factors, RNA polymerase II, and epitope-tagged proteins.

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• RRID
• 2 years ago - submitted by Yi Liu

Web server for predicting protein toxicity. Protein toxicity classifier, which relies on protein primary sequence. Used for predicting toxicity of biologics.

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• RRID
• 2 years ago - by Anonymous

Software tool for determination of dispersion risks due to leaching and for determination of soil quality evolution.

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• RRID
• 2 years ago - by Anonymous