Curator Dashboard

Core experts offers complex gene therapy trials. Ensures licensed gene therapies are available in our clinics.

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• SciCrunch
• 3 months ago - submitted by Edyta Vieth

Core provides manufacturing of clinical and pre-clinical Adeno-Associated Virus (AAV) vectors of serotypes 1, 2, 5, 6, 8, 9, and Lentivirus (LV) vectors. Novel or modified serotypes will require development prior to scale-up. Products for clinical use are manufactured in compliance with Current Good Manufacturing Practices (cGMP) for Phase 1 and 2 clinical trials. To support pre-clinical work, including pharmacology and toxicology studies, core offers products manufactured using a GMP-comparable process. Research-grade products for proof-of- principle and bridging studies are also offered.Core Facility uses a patented vector production technology and a highly efficient purification process that uses combined column and gradient centrifugation-based process steps. This system has manufactured clinical-grade AAV vectors. Prior to the final release of the clinical vectors, the vector product is subjected to numerous tests to ensure quality. Core also provides federal regulatory documentation and necessary certifications.

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• SciCrunch
• 3 months ago - submitted by Edyta Vieth

Core offers services and access to single-cell, spatial and in situ technologies. Provides instruments, experienced research assistants and bioinformaticians to experimental and computational support. Services include 10x Genomics single cell assays, 10x Genomics Visium CytAssist and Visium HD spatial transcriptomics, 10x Genomics Xenium in situ spatial transcriptomics, Vizgen MERSCOPE in situ spatial transcriptomics, NanoString GeoMx Digital Spatial Profiler RNA and protein assays.

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• SciCrunch
• 3 months ago - submitted by Edyta Vieth

Core is equipped with liquid handling technology and experienced staff members. Offers both standard and custom Illumina array project design. With the capacity to process >2300 samples/week and generate >480 million genotypes per day, the genotyping core fully integrates with our Biorepository and Bioinformatics group, offering the collaborator the opportunity for a seamless experience from DNA extraction to data release.

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• SciCrunch
• 3 months ago - submitted by Edyta Vieth

Pediatric biobank, hosting more than 600,000 biological samples that have been genotyped or sequenced in CAGs CLIA and CAP-accredited high-throughput centers. This core offers services in DNA and RNA extraction and QC.

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• SciCrunch
• 3 months ago - submitted by Edyta Vieth

Core is service facility providing instrumentation, library preparation, and sequencing services to CHOP, UPenn, and external investigators in genomic, epigenomic and transcriptomic studies.

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• SciCrunch
• 3 months ago - submitted by Edyta Vieth

Transgenic Core at Childrens Hospital Research Institute, working in partnership with the University of Pennsylvania CRISPR Core Facility, build complex mouse and rat models,genetically manipulating the mouse and rat genome to meet specific research needs utilizing genetic engineering approaches. Core provides services for the generation and preservation of genetically altered mice or rats.

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• SciCrunch
• 3 months ago - submitted by Edyta Vieth

Core consists of an Inductively Coupled Plasma-Mass Spectrometry (ICP-MS) laboratory, an X-ray Fluorescence laboratory, a Raman laboratory, and an optical mineralogy laboratory. Museum curators and researchers are using this instrumentation extensively to further research programs on early state expansion in the Andes, evolving social networks on the north coast of Papua New Guinea, the social dynamics of early village societies and the emergence of early states, African pre-industrial civilizations and, trade and exchange around the Indian Ocean (Laure Dussubieux). In addition to research conducted by Field Museum staff, the EAF collaborates with scientists from other institutions, bringing researchers and students from all over the country to The Field Museum to learn about compositional analysis of ancient materials to enhance their research on a very wide range of anthropological topics.

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• RRID
• 3 months ago - submitted by Laure Dussubieux

Scientific and educational institution dedicated to exploring the diversity of life on Earth and human culture. It is renowned for its collection of over 40 million artifacts and specimens, including world-class dinosaur fossils, ancient cultural exhibits, and active scientific research labs.

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• RRID
• 3 months ago - submitted by Edyta Vieth

Interdepartmental core facility for scanning electron microscope imaging and elemental analysis of objects. Provides Hitachi SU7000 field emission scanning electron microscope, an Oxford Ultim Max 170 infinity EDS detector with BEX (backscatter electron and X-ray imaging detector), a Leica EM Ace600 sputter coater and a Hitachi IM4000II ion milling system.

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• RRID
• 3 months ago - submitted by Stephanie Ware

ECHO project to better understand the effects of physical, chemical, and biological exposures, social and behavioral factors, and the natural and built environments on child health and development, with focus in the following areas: Pre-, peri-, and post-natal outcomes; Upper and lower airway; Obesity; Neurodevelopment; and Positive health To achieve this goal, the ECHO program supports multiple, synergistic, longitudinal studies of existing and ongoing study cohorts.

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• RRID
• 3 months ago - submitted by Wayne Huggins

Software Python package for interactive and static data visualization.Interactive visualization library for modern web browsers. Provides concise construction of graphics and affords high-performance interactivity across large or streaming datasets.

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• RRID
• 3 months ago - by Anonymous

Project to quantify the impact of longitudinal predictive models with single- or multisource data for predicting MCI-to-AD conversion and identifying a very small subset of features that are highly predictive of conversion.

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• NIF
• 3 months ago - submitted by Albert Crowley

Core generates induced pluripotent stem cell (iPSC) lines from somatic cells including peripheral blood mononuclear cells and fibroblasts. The Core has established standard operating procedures for Pluripotent stem cell growth and maintenance, Genome editing technologies including CRISPR-CAS9 and Differentiation to germ layer and derivative tissues of interest. Provides enrichment training courses for investigators interested in learning how to work with pluripotent stem cells and/or establish the pluripotent stem cell technology in their own labs.

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• SciCrunch
• 3 months ago - submitted by Edyta Vieth

Core offers services for preclinical models including barrier facilities with fully automated environmental controls for the housing of research models. Specialized husbandry with trained staff who perform all manipulations inside Biosafety cabinets for maintenance of a pathogen-free environment for models held in micro isolation (MI) housing systems. In addition to housing pre-clinical models in state-of-the-art facilities, COSR provides Specialized Surgical Services and procedural training, consultation in experimental design, irradiation services, in-house hematological testing, genotyping services, design and conduct of pre-clinical toxicological studies.

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• SciCrunch
• 3 months ago - submitted by Edyta Vieth

Core provides specialized preclinical imaging services including image acquisition, quantitative image analysis, multidimensional renderings and data sets for research purposes.

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• SciCrunch
• 3 months ago - submitted by Edyta Vieth

Benchtop, multispectral imaging flow cytometer that merges the high-throughput, quantitative capabilities of flow cytometry with the visual detail of microscopy. It captures up to 12 channels of images including brightfield, darkfield, and fluorescence for every cell in flow, allowing researchers to study protein localization, cell-cell interactions, and morphology at a rate of thousands of cells per second.

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• RRID
• 3 months ago - by Anonymous

Laboratory instrument designed for cell and tissue culture, providing precise temperature (up to 55°C) and CO2 control for optimal, stable growth conditions. It features air-jacketed heating, a fast-recovering humidification system, and options for stainless steel or copper interiors to reduce contamination risk.

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• RRID
• 3 months ago - by Anonymous

Compact imaging system designed for chemiluminescence, fluorescence (including IR) and colorimetric detection. Built with advanced charge-coupled device (CCD) technology, it delivers high-resolution, publication-quality images across a wide range of applications—including gels, membrane blots, multiwell plates and petri dishes.

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• RRID
• 3 months ago - by Anonymous

Core facility that helps biomedical researchers design and execute proteomics (and metabolomics/lipidomics) studies from sample preparation and LC-MS/MS data acquisition to protein/PTM identification and quantification and advanced bioinformatics/statistical analysis. CPD supports workflows, including label-free (DIA/DDA) and TMT multiplexed quantitative proteomics, phosphoproteomics/other PTMs, targeted PRM, single-cell proteomics, spatial proteomics, cell-type-specific proteomics, thermal proteome profiling, and more.

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• RRID
• 3 months ago - submitted by Chan-Hyun Na