We support boolean queries, use +,-,<,>,~,* to alter the weighting of terms
Transgenic Core at Childrens Hospital Research Institute, working in partnership with the University of Pennsylvania CRISPR Core Facility, build complex mouse and rat models,genetically manipulating the mouse and rat genome to meet specific research needs utilizing genetic engineering approaches. Core provides services for the generation and preservation of genetically altered mice or rats.
Core consists of an Inductively Coupled Plasma-Mass Spectrometry (ICP-MS) laboratory, an X-ray Fluorescence laboratory, a Raman laboratory, and an optical mineralogy laboratory. Museum curators and researchers are using this instrumentation extensively to further research programs on early state expansion in the Andes, evolving social networks on the north coast of Papua New Guinea, the social dynamics of early village societies and the emergence of early states, African pre-industrial civilizations and, trade and exchange around the Indian Ocean (Laure Dussubieux). In addition to research conducted by Field Museum staff, the EAF collaborates with scientists from other institutions, bringing researchers and students from all over the country to The Field Museum to learn about compositional analysis of ancient materials to enhance their research on a very wide range of anthropological topics.
Scientific and educational institution dedicated to exploring the diversity of life on Earth and human culture. It is renowned for its collection of over 40 million artifacts and specimens, including world-class dinosaur fossils, ancient cultural exhibits, and active scientific research labs.
Interdepartmental core facility for scanning electron microscope imaging and elemental analysis of objects. Provides Hitachi SU7000 field emission scanning electron microscope, an Oxford Ultim Max 170 infinity EDS detector with BEX (backscatter electron and X-ray imaging detector), a Leica EM Ace600 sputter coater and a Hitachi IM4000II ion milling system.
ECHO project to better understand the effects of physical, chemical, and biological exposures, social and behavioral factors, and the natural and built environments on child health and development, with focus in the following areas: Pre-, peri-, and post-natal outcomes; Upper and lower airway; Obesity; Neurodevelopment; and Positive health To achieve this goal, the ECHO program supports multiple, synergistic, longitudinal studies of existing and ongoing study cohorts.
Software Python package for interactive and static data visualization.Interactive visualization library for modern web browsers. Provides concise construction of graphics and affords high-performance interactivity across large or streaming datasets.
Project to quantify the impact of longitudinal predictive models with single- or multisource data for predicting MCI-to-AD conversion and identifying a very small subset of features that are highly predictive of conversion.
Core generates induced pluripotent stem cell (iPSC) lines from somatic cells including peripheral blood mononuclear cells and fibroblasts. The Core has established standard operating procedures for Pluripotent stem cell growth and maintenance, Genome editing technologies including CRISPR-CAS9 and Differentiation to germ layer and derivative tissues of interest. Provides enrichment training courses for investigators interested in learning how to work with pluripotent stem cells and/or establish the pluripotent stem cell technology in their own labs.
Core offers services for preclinical models including barrier facilities with fully automated environmental controls for the housing of research models. Specialized husbandry with trained staff who perform all manipulations inside Biosafety cabinets for maintenance of a pathogen-free environment for models held in micro isolation (MI) housing systems. In addition to housing pre-clinical models in state-of-the-art facilities, COSR provides Specialized Surgical Services and procedural training, consultation in experimental design, irradiation services, in-house hematological testing, genotyping services, design and conduct of pre-clinical toxicological studies.
Core provides specialized preclinical imaging services including image acquisition, quantitative image analysis, multidimensional renderings and data sets for research purposes.
Benchtop, multispectral imaging flow cytometer that merges the high-throughput, quantitative capabilities of flow cytometry with the visual detail of microscopy. It captures up to 12 channels of images including brightfield, darkfield, and fluorescence for every cell in flow, allowing researchers to study protein localization, cell-cell interactions, and morphology at a rate of thousands of cells per second.
Laboratory instrument designed for cell and tissue culture, providing precise temperature (up to 55°C) and CO2 control for optimal, stable growth conditions. It features air-jacketed heating, a fast-recovering humidification system, and options for stainless steel or copper interiors to reduce contamination risk.
Compact imaging system designed for chemiluminescence, fluorescence (including IR) and colorimetric detection. Built with advanced charge-coupled device (CCD) technology, it delivers high-resolution, publication-quality images across a wide range of applications—including gels, membrane blots, multiwell plates and petri dishes.
Core facility that helps biomedical researchers design and execute proteomics (and metabolomics/lipidomics) studies from sample preparation and LC-MS/MS data acquisition to protein/PTM identification and quantification and advanced bioinformatics/statistical analysis. CPD supports workflows, including label-free (DIA/DDA) and TMT multiplexed quantitative proteomics, phosphoproteomics/other PTMs, targeted PRM, single-cell proteomics, spatial proteomics, cell-type-specific proteomics, thermal proteome profiling, and more.
Modern 120 kV Transmission Electron Microscope (TEM) designed for high-throughput screening and ease of use in biological, materials science, and nanotechnology research. Resolution: Achieves 0.14 nm (High Resolution) to 0.2 nm (High Contrast) lattice resolution. Magnification: Range from x50 to x1,500,000 (HR) or x1,200,000 (HC). Imaging System: Includes a 4-megapixel, high-speed, high-sensitivity JEOL CMOS camera (NeoView) as standard, with options for a 19-megapixel (SightSKY) camera. Versatile Applications: It can be used for cryo-TEM screening, material sciences, and high-throughput asbestos analysis.
Core services include experimental design, sample size calculation, randomization, analysis plans, data analysis, grant and manuscript preparation, full clinical trial support, and innovative targeted methods development.
High pressure, precision solvent mixing pumps designed for HPLC and preparative scale purification. They mix two different solvents to create precise gradient compositions, allowing for, or improving, the separation and isolation of target compounds in chemical or biological samples.
Compact benchtop single quadrupole mass spectrometer designed for routine, high-performance liquid chromatography (LC-MS) applications. Used for molecular weight confirmation, impurity identification, and quantitative analysis. Compatible with a broad range of chromatography platforms and ionization sources, including APCI and UniSpray, the SQ Detector 2 is the ultimate single quadrupole mass detector for chromatography.
Core oversees the operation of research animal facilities at the University of Vermont. Animal facilities houses mainly mice and rats. Animal models facilitate discovery in the areas of infectious disease, endocrinology and metabolic disease, cancer and chemotherapy, immunology and respiratory disease, among others. The University of Vermont's Animal Care program is fully accredited by the Association for the Assessment and Accreditation of Laboratory Animal Care (AAALAC, International).
Core offers streamlined, multiplexed tissue analysis services including tissue sectioning, staining, imaging, spatial RNA sequencing, analysis and interpretation of results.