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Thermogravimetric analyzer used to measure a material’s weight change (decomposition, oxidation, or dehydration) as it is heated, cooled, or held at a constant temperature. It is used in research and quality control to analyze polymers, pharmaceuticals, and composites for stability and composition.

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• 3 months ago - by Anonymous

Core Facility for the development and manufacturing of experimental medical devices. Offers advise on experimental design, draft technical proposals, and support in the realization of prototypes and patent ideas.

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• 3 months ago - submitted by Jan-Erik Ode

Software Python package for network analysis and Leiden community detection/clustering algorithm commonly used in single cell analysis for biology.

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• 3 months ago - by Anonymous

Software R package for annotating gene lists and converting between identifiers.

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• 3 months ago - by Anonymous

Software R package provides some legacy utility functions for performing single-cell analyses. Most of these functions are deprecated in favor of newer, more performant alternatives. We just keep this package around for back-compatibility and to point to the replacement functions.

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• 3 months ago - by Anonymous

Software R package for access to processed 10x (droplet) and SmartSeq2 (on FACS-sorted cells) single-cell RNA-seq data from the Tabula Muris consortium.

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• 3 months ago - by Anonymous

Software R package for collection of public scRNA-seq datasets, provided as SingleCellExperiment objects with cell- and gene-level metadata.

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• 3 months ago - by Anonymous

Cores Sequencing operations are integrated with Biorepository and Bioinformatics teams to keep all stages of a collaborators studies connected. Core offers genomics services in NovaSeq, Single Cell 10xGenomics, various library preparations including bulk RNAseq, Whole Genome/Whole Exome, and Sanger Sequencing including fragment analysis.

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• SciCrunch
• 3 months ago - submitted by Edyta Vieth

Core provides services and expertise to advance chimeric antigen receptor (CAR) T or other cell therapy research.Services include guidance in the design, construction, and selection of CARs and other cell therapies against a multitude of targets and diseases. Core offers small-scale lentivirus production and small-scale T cell transduction and expansion for experimental purposes.

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• SciCrunch
• 3 months ago - submitted by Edyta Vieth

Core offers zebrafish research services and provides fish husbandry. Services include experiments designing and performing, teaching zebrafish techniques.Provides special expertise in disease modeling by creation of mutant and transgenic lines, analysis of disease phenotypes, and drug testing.

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• SciCrunch
• 3 months ago - submitted by Edyta Vieth

Core facility specializes in mass spectrometry-based proteomics with a commitment to quality, rigor, problem-solving, and innovation. Provides expert guidance

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• SciCrunch
• 3 months ago - submitted by Edyta Vieth

Core supports all Children's Hospital of Philadelphia Research Institute personnel and faculty who are interested in utilizing qualitative methods. Provides research support across a broad range of settings, including in-hospital clinical research, primary care, public health, and community-based settings. Services include free introductory videos, yearly seminars, customized project workshops, and hands-on project support and grantmaking.

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• SciCrunch
• 3 months ago - submitted by Edyta Vieth

Core focuses on quantitative bioanalytical assay development, validation and implementation for drugs, metabolites and biomarkers in blood, serum, plasma, urine, ultrafiltrate and microdialysate utilizing mass spectrometry techniques.

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• SciCrunch
• 3 months ago - submitted by Edyta Vieth

Core offers biostatistics and data management services, expertise in the design of experiments, planning of clinical protocols, analysis and interpretation of data, and presentation and dissemination of results. Services include designing case report forms, developing databases, creating data management plans, developing metrics to report on study progress, and delivering high quality datasets for analysis. Core offers free limited consulting for data management and statistical questions. Offers experience with the submission of a Biologics License Application (BLA). Core is available to investigators seeking guidance with clinical trial start-up, oversight, and regulatory submission.

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• SciCrunch
• 3 months ago - submitted by Edyta Vieth

Core provides premium recombinant adeno-associated viral (AAV) and lentiviral vectors to support basic research and preclinical studies. Provides expertise in producing custom vector constructs at multiple scales, rigorous quality control standards, and technical support. Services enable gene transfer and accelerate translational research and therapeutic development.

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• SciCrunch
• 3 months ago - submitted by Edyta Vieth

Core is sequencing and analytical resource of the PennCHOP Microbiome Program, providing end-to-end solutions for microbiome research. Sequencing lab offers expertise in next-generation DNA sequencing for microbiome studies, working with customers to provide optimized workflows and protocols customized for each study. Provides expertise in bioinformatics and statistical analysis of microbiome data. Develops an analytical plan specific to your project and can integrate microbiome data with other data sources, such as metabolomics or dietary intake information.

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• SciCrunch
• 3 months ago - submitted by Edyta Vieth

Core provides support for nonclinical research programs. Offers expertise to design, conduct, and oversee a wide range of animal studies. Services include Grant and funding application support, Budget development and financial planning, Experimental design and study planning, Study protocol drafting, implementation, and management, IACUC protocol guidance and consultation, Standard Operating Procedure (SOP) development, management, and archiving, Training delivery and documentation, Study execution and data generation, Secure archiving of study materials and data. Core offers expertise in Pharmacokinetic studies, Biodistribution studies, Toxicology and reproductive toxicology studies, Medical device testing, Surgical model development.

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• SciCrunch
• 3 months ago - submitted by Edyta Vieth

Core provides histopathology, Immunohistochemistry, tissue microarray, and imaging services. Staff offer experience in all aspects of tissue processing, histological techniques, antibody work-up, and morphologic analysis. Offers tools to facilitate high throughput analysis of tissue sections and imaging. The Pathology Core is located in the A Level of Colket Translational Research Building (CTRB) Room A410. Staff is available for consultation, troubleshooting, and assistance in planning and interpreting experiments histopathology and related techniques.

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• SciCrunch
• 3 months ago - submitted by Edyta Vieth

Core serves CHOP researchers with translational imaging capabilities. Provided imaging platform integrates multiple modalities including MRI, PET, CT, Optical, and US for monitoring disease progression and therapeutic response in vivo in small animal models. Services include Selecting the optimal imaging modality, Design and optimization of acquisition protocols, Expert execution of in vivo imaging experiments, Training for new users on image acquisition, Advanced data analysis and project management.Provides technical expertise and translational capability.

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• SciCrunch
• 3 months ago - submitted by Edyta Vieth

Core facilitates advanced MR image-guided interventional and noninvasive procedures to support research across a broad range of disease areas, including neurodegenerative, cardiothoracic, and reproductive disorders. Imaging capabilities span structural MRI, diffusion imaging, DCE and ASL perfusion, spectroscopy, angiography, cardiac imaging, tissue elastography, functional imaging, flow quantification, and quantitative T1, T2, and T2* mapping.In collaboration with the Division of Veterinary Resources (DVR), we encourage investigators to consult with our teams on all scientific, medical, technical, and compliance aspects of studies involving large animal models. Investigators are expected to obtain Institutional Animal Care and Use Committee (IACUC) approval before initiating study activities. Core provides comprehensive data processing, post-processing, and quantitative image analysis support to help investigators extract meaningful outcomes from complex imaging datasets. These services include image reconstruction workflows, multimodal image registration, segmentation, volumetric and regional quantification, diffusion and tract-based analysis, spectroscopy processing, and development of customized pipelines tailored to specific study needs.Provides support in generating high-quality preliminary data for grant applications, instrument proposals, and translational research initiatives by helping design imaging strategies, optimize acquisition protocols, and deliver rigorous quantitative analyses that strengthen scientific aims.For larger research programs, the LAIF Core can assist with processing and managing large-scale imaging datasets to support longitudinal studies, multisubject analyses, and publication-ready results.

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• SciCrunch
• 3 months ago - submitted by Edyta Vieth